Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals by Jacinta Nwamaka Nwogu, Qing Ma, Chinedum Peace Babalola, Waheed Adeola Adedeji, Gene D. Morse, Babafemi Taiwo

“…Other factors are related to pharmacokinetics and pharmacogenetics of the specific ARV agent or mediated by drug interactions, local inflammation, and blood flow. …”
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Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy by Peter J Jewesson

“…Recognition of the pharmacokinetic characteristics of these oral agents is essential lo successful therapy. …”
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Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs by Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, Kenji Tani, Eiji Kobayashi, Motoaki Sano

“…Here, we verified the pharmacokinetics of hydrogen after the infusion of hydrogen-saturated saline. …”
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Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Abstract Iruplinalkib (WX‐0593), a selective oral ALK/ROS1 tyrosine kinase inhibitor, was approved in China as first‐line therapy for ALK‐positive non‐small‐cell lung cancer (NSCLC) and for the treatment of locally advanced or metastatic ALK‐positive NSCLC that has progressed following crizotinib therapy. Pharmacokinetics (PK) data of iruplinalkib have been collected in healthy subjects and patient populations in several studies. …”
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Effect of Hematopoietic Stem Cell Transplantation Regimen on Tacrolimus Pharmacokinetics by Haruno Oku, BS, Saki Yoshida, BS, Takumi Hotta, BS, Hirohito Muroi, BS, Keizo Fukushima, PhD, Kei Irie, PhD, Tatsuya Hirano, BS, Yoshimitsu Shimomura, MD, Takayuki Ishikawa, MD, PhD, Hiroaki Ikesue, PhD, Nobuyuki Muroi, PhD, Tohru Hashida, PhD, Nobuyuki Sugioka, PhD

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Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment by Moiz Mumtaz, Jeffrey Fisher, Benjamin Blount, Patricia Ruiz

“…This process is increasingly adopting “in silico” tools such as physiologically based pharmacokinetic (PBPK) models to fine-tune exposure assessments and determine internal doses in target organs/tissues. …”
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Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats by Zhou Zhaoxiang, Wang Meng, Guo Zengjun, Zhang Xiaoying

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Cimetidine Pharmacodynamics and Pharmacokinetics in Healthy Subjects: A Comparison of Tablets and Suspension by ABR Thomson, P Kirdeikis, L Zuk, RE Samuels, P Zarevics

“…Comparing cimetidine concentration (Cmax) and lower percentage time plasma cimetidine concentration was at least 0.5 μg/mL (the minimum therapeutic level). These pharmacokinetic variations between cimetidine suspension and tablets may have partially explained the pharmacodynamic differences of the lower area under the pH time curve (0 to 6 h). …”
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Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons by Yang-Guang Jin, Yue Liu, Yan-Ni Zhang, Yu-Xin Chen, Long-Ji Sun, Shi-Hao Li, Wen-Rui Wang, Fan Yang

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Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows by Tushar Jain, Bianka Prinz, Alexander Marker, Alexander Michel, Katrin Reichel, Valerie Czepczor, Sylvie Klieber, Wei Sun, Sagar Kathuria, Sevim Oezguer Bruederle, Christian Lange, Lena Wahl, Charles Starr, Alessandro Masiero, Lindsay Avery

“…In vitro assessments for the prediction of pharmacokinetic (PK) behavior of biotherapeutics can help identify corresponding liabilities significantly earlier in the discovery timeline. …”
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Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics by Li Ting-Ting, Xie Jian-Zhong, Wang Ling, Gao Yang-Yang, Jiang Xue-Hua

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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

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Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy by Chiao-Shih Tseng, Shih-Ming Chen, Shu-Chen Chien, Kuang-Yang Hsu

“…To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, New Zealand white rabbits were used in this study. …”
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Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers by Wang Fengling, Chen Jin, Dai Wenting, He Zhengmin, Zhai Dandan, Chen Weidong

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Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure by Abdullah Duhaim, Tariq Abdullah Almatroudi, Zaiad Abdullah Alghidani, Abdulsalam Saad Alhunayni, Mohamed Helmy Salama

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Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients by Yanping Guan, Bilian Li, Yiyu Zhang, Hao Luo, Xueding Wang, Xue Bai, Zhuoling Zheng, Yaying Huang, Wei Wei, Min Huang, Xingrong Song, Guoping Zhong

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Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics by Ibrahim El-Serafi, Sinclair Steele

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The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis by Mubara Azhar, Mohammed S. Alasmari, Ammara Zamir, Hamid Saeed, Faleh Alqahtani, Tanveer Ahmad, Muhammad Fawad Rasool

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Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…The nanoformulations underwent several tests, including minimum inhibitory concentration, in vivo efficacy on an infected mouse model, pharmacokinetic assessments, tissue distribution, and toxicity. …”
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Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids by Gaber, El-Saber Batiha, Ali, Alqahtani, Oluwafemi, Adeleke Ojo, Hazem M., Shaheen, Lamiaa, Wasef, Mahmoud, Elzeiny, Mahmoud, Ismail, Mahmoud, Shalaby, Toshihiro, Murata, Adrian, Zaragoza-Bastida, Nallely, Rivero-Perez, Amany, Magdy Beshbishy, Keneth, Iceland Kasozi, Philippe, Jeandet, and Helal F., Hetta

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