Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…We set out to describe what is known and unknown about the mechanisms underlying the interplay between antigenicity and immune response and their effect on the safety, efficacy, pharmacokinetics, and pharmacodynamics of these therapeutic agents.…”
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In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase by Rishab Marahatha, Asmita Shrestha, Kabita Sharma, Bishnu P. Regmi, Khaga Raj Sharma, Pramod Poudel, Ram Chandra Basnyat, Niranjan Parajuli

“…The QSAR analysis was conducted by using the way2drug/PASS online web resource, and the pharmacokinetics and toxicity properties of these alkaloids were predicted using pkCSM, SwissADME, and ProTox-II webserver. …”
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Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes by Mohammad A. Bani-Ahmad, Ayman G. Mustafa, Abdelraheem A. Bani Ahmad, Islam E. Alkhazali, Ahmad A. Rahim

“…Considering the pharmacokinetics of heroin, erythrocytic antioxidant mechanisms, and turnover rate, further investigation is required to evaluate the extent and clinical outcomes, especially upon over-dose administration.…”
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High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report by Fatimatuz Zahro, Tita Sugesti, Siska Hermawati, M. Hari Pristantiningtyas, Herya Putra Dharma, Muhammad Muchlis, Jainuri Erik Pratama, Fauna Herawati, Adji Prayitno, Marisca Evalina Gondokesumo

“…Strategies for managing hyperglycemia should be tailored to the pharmacokinetics of glucocorticoids and insulin.…”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling

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Evaluation of Waste Anesthetic Gas in the Postanesthesia Care Unit within the Patient Breathing Zone by Kenneth N. Hiller, Alfonso V. Altamirano, Chunyan Cai, Stephanie F. Tran, George W. Williams

“…Observed WAGs in our study were explained by inhalational anesthetic pharmacokinetics. Further analysis suggests that the rate of washout of sevoflurane was dependent on the duration of anesthetic exposure. …”
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Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine by Srikar Grandhi, Moawia Al-Tabakha, Prameela Rani Avula

“…The results of in vivo pharmacokinetics from blood and liver tissues indicated that hepatic bioavailability of LMV was increased from 13.78 ± 3.48 μg/mL ∗ h for LMV solution to 32.94 ± 5.12 μg/mL ∗ h for the optimized LMV-ACNs and to 54.91 ± 6.68 μg/mL ∗ h for the surface-modified LMV-ACNs.…”
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Exploring the therapeutic potential of Asparagus africanus in polycystic ovarian syndrome: a computational analysis by Riaz Sania, Haider Fatima, ur-Rehman Rizwan-, Zafar Aqsa

“…The results underscored the lead compound’s superiority, demonstrating favorable pharmacokinetics, ADME characteristics, and strong molecular binding without any observed toxicity in comparison to standard drug. …”
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Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation by Gagganapalli Santhoshi Reddy, Usha Yogendra Nayak, Praful Balavant Deshpande, Srinivas Mutalik

“…The FPRT formulation improved pharmacokinetic parameters compared to immediate release tablet formulation in terms of extent of absorption in rabbits. …”
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The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics by Arwa M. Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Muhamad Ali SK Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim

“…Current methods for clopidogrel personalization include CYP2C19 genotyping, pharmacokinetics, and platelets function testing. However, these methods lack precise prediction of clopidogrel outcome, often leading to insufficient prediction. …”
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RGD-Human Serum Albumin Conjugates as Efficient Tumor Targeting Probes by Kai Chen, Jin Xie, Xiaoyuan Chen

“…The success of this study may be generalizable for other peptide-based probes to be conjugated with HSA for prolonged tumor contrast and improved pharmacokinetics.…”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Through resulting antibacterial activity, results were compared to standard medications and it was discovered that a couple of synthesized compounds had nearly the same value as standard drugs. The pharmacokinetics, drug-likeness, and physicochemical characteristics were predicted by the SwissADME software. …”
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Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO) by Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Anand Mohan, Neeta Raj Sharma, Pratima R. Solanki, Anil Kumar

“…These findings provide a foundation for understanding the pharmacodynamics and pharmacokinetics of TMAO and may aid in developing strategies for treating diseases, such as chronic kidney disease and neurological disorder where TMAO-serum albumins interaction are implicated.…”
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Pharmacomicrobiomics: a new field contributing to optimizing drug therapy in Parkinson’s disease by Yi Zhang, Chengjun Mo, Penghui Ai, Xiaoqin He, Qin Xiao, Xiaodong Yang

“…Gut microbiota, which act as a determinant of pharmacokinetics, have long been overlooked. In recent years, a growing body of evidence indicates that the gut microbiota influence drug metabolism and efficacy. …”
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Biochemical Behaviours of Salmeterol/Fluticasone Propionate in Treating Asthma and Chronic Obstructive Pulmonary Diseases (COPD) by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…Analysing such therapies is daunting since coadministration interferes with pharmacology and pharmacokinetics of drugs. This work focuses on salmeterol/fluticasone propionate combination and aspects which has to do with administration, monitoring, metabolism, toxicity, and adverse effects.…”
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The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke by Katherine Hernandez, Nathan Jones, Sterling B. Ortega

“…Additionally, an assessment of neuroinflammation revealed no changes in CD4 T-cell cellularity or phenotype.DiscussionThese findings, alongside prior studies, suggest that the therapeutic efficacy of PNU may be contingent upon the timing of administration, dosage, and pharmacokinetics.…”
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Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains by Gangadhar Dhulipala, Alanna Broszeit, Kun Lu, Nisha Palackal, Erica Pyles

“…It can impact the stability, efficacy, and safety of products, but it can also affect the pharmacokinetics, binding affinity, and overall biological activity of the molecules. …”
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PET imaging of AAV9 and AAVBR1 trafficking in normal mice by Aditya Bansal, Shalini Sharma, Manasa Kethamreddy, Mukesh K. Pandey

“…The developed methodology provides a noninvasive approach to image the pharmacokinetics of AAVs in a longitudinal manner and renders a selection of specific AAV serotypes for tissue/organ specific targeting.…”
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Biotin interference with laboratory test results by Strilić David Z., Stanimirov Bojan G., Đanić Maja P.

“…It explores the pharmacokinetics of biotin elimination and the prevalence of elevated biotin levels in patient populations. …”
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Successfully Treated Calcific Uremic Arteriolopathy: Two Cases of a High Anion Gap Metabolic Acidosis with Intravenous Sodium Thiosulfate by Joshua L. Rein, Kana N. Miyata, Kobena A. Dadzie, Steven J. Gruber, Roxana Sulica, James F. Winchester

“…Although STS should be considered in the treatment of CUA, little is known about pharmacokinetics and additional studies are required to determine dosing strategies to minimize severe potential side effects.…”
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