Multifunctional Synthetic Poly(-Glutamic Acid)–Based Cancer Therapeutic and Imaging Agents by Marites P. Melancon, Chun Li

“…Having both an anticancer drug and an imaging reporter in a single polymer chain allows noninvasive real-time visualization of the pharmacokinetics of polymeric drug delivery systems, which can uncover and explain the complicated mechanisms of in vivo drug delivery and their correlation to pharmacodynamics. …”
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Effect of Volume and Renewal of the Storage Media on the Release of Monomer from Dental Composites by Sima Shahabi, Maryam Sayyari, Sima Sadrai, Sara Valizadeh, Hamidreza Hajizamani, Alireza Sadr

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Modeling Drug Concentration Level in Blood Using Fractional Differential Equation Based on Psi-Caputo Derivative by Muath Awadalla, Yves Yannick Yameni Noupoue, Kinda Abu Asbeh, Noureddine Ghiloufi

“…This article studies a pharmacokinetics problem, which is the mathematical modeling of a drug concentration variation in human blood, starting from the injection time. …”
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Transportation Laws for Carbonate and Sulfate Ions in Concrete Based on Compartment Model by Boxin Wang, Ruichang Fang, Xu Chai, Qing Wang

“…Given this similarity, such a process is described dynamically using the classic compartment model in pharmacokinetics. The compartment model was applied to predict the content of carbonate and sulfate ions in different regions of concrete. …”
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How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies by Yi Yang, Fu Kuang, XueYing Zhu, Li Li, Yao Huang, Yang Liu, Xian Yu

“…Abstract Background The euglycemic clamp test stands as the best method for assessing the pharmacokinetic and pharmacodynamic properties of long-acting insulin. …”
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In silico approach in the development of structural analogues of resveratrol with improved distribution in the central nervous system by Mitrović Darko, Pavlović Nebojša

“…To improve the pharmacological profile, one of the strategies is the structural modification and selecting an analogue that would activate SIRT1 and improve pharmacokinetics. The aim was to examine the neuroprotective potential of resveratrol analogues through the analysis of the binding affinity to the sirtuin-1 receptor and with improved permeability through the blood-brain barrier. 15 of them have a higher affinity for the target. …”
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Viloxazine, a Non-stimulant Norepinephrine Reuptake Inhibitor, for the Treatment of Attention Deficit Hyperactivity Disorder: A 3 Year Update by Hannah W Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“…Related to its long-standing use as an antidepressant, the safety profile and pharmacokinetics of viloxazine are well understood. Viloxazine appears to be a suitable alternative to current standard-of-care pharmacotherapy for ADHD, but the further investigation remains to be done in comparing its efficacy to that of current treatments.…”
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Current Potential of Pantoprazole in Treatment and Prevention of Gastrointestinal Diseases by A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

“…It minimally inhibits the CYP2C19 isoenzyme involved in the metabolism of many drugs. Pharmacokinetics of pantoprazole conditions a weaker drug interaction compared to other proton pump inhibitors (PPIs), which enables its use for gastrointestinal bleeding prevention in patients receiving dual antiplatelet therapy. …”
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Applications of Au₂₅ Nanoclusters in Photon-Based Cancer Therapies by Zoey A. Lockwood, Michael R. Jirousek, James P. Basilion, Clemens Burda

“…Ongoing research aims to better understand their pharmacokinetics, biodistribution, and long-term safety, paving the way for their broader application in advanced cancer therapies.…”
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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions by Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao

“…Its liposomal formulations provide sustained release and higher tissue penetration with improved pharmacokinetics and enhanced therapeutic efficacy. Preclinical studies revealed that nanocurcumin drastically lower oxidative stress indicators, inflammatory cytokines, and cardiac damage. …”
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Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies by Michael A. Partridge, Shobha Purushothama, Chinnasamy Elango, Yanmei Lu

“…Anti-drug antibodies induced by biologic therapeutics often impact drug pharmacokinetics, pharmacodynamics response, clinical efficacy, and patient safety. …”
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Heat stable and intrinsically sterile liquid protein formulations by Atip Lawanprasert, Harminder Singh, Sopida Pimcharoen, Mariangely González Vargas, Arshiya Dewan, Girish S. Kirimanjeswara, Scott H. Medina

“…These non-aqueous formulations are impervious to contamination by microorganismal pathogens, degradative enzymes, and environmental impurities, and display comparable pre-clinical pharmacokinetics and safety profiles to standard saline protein samples. …”
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A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors by Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

“…The primary endpoints were safety and to determine the maximum tolerated dose (MTD) based on dose limiting toxicities (DLTs). Pharmacokinetics and anti-tumor efficacy of GQ1001 were assessed. …”
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The canine blood-brain barrier in health and disease: focus on brain protection by Dimitri Bassalo, Stephen G. Matthews, Enrrico Bloise

“…We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the ABCB1/MDR1 gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics. The review also covers factors that may disrupt the canine BBB, including the actions of aging, canine cognitive dysfunction, epilepsy, inflammation, infection, traumatic brain injury, among others. …”
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Chemical Profiling Ethyl Acetate Extract of <i>Basilicum polystachyon</i> Leaves and Exploration of Anticancer SIRT1 Inhibitors Using <i>In Silico</i> Approach by Tukiran Tukiran, Muhammad Raihan

“…The prediction of these compounds' physicochemical properties and pharmacokinetics showed promising results and fulfilled the medicinal compound's criteria. …”
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Molecular Docking, Dynamics Simulations, ADMET, and DFT Calculations: Combined In Silico Approach to Screen Natural Inhibitors of 3CL and PL Proteases of SARS-CoV-2 by Sugumar Mohanasundaram, Porkodi Karthikeyan, Venkatesan Sampath, M. Anbazhagan, Sundramurthy Venkatesa Prabhu, Jamal M. Khaled, Muthu Thiruvengadam

“…In addition, the crucial properties like drug likeliness and pharmacokinetics of the compounds were determined. There is no significant toxicity identified.…”
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Once-Daily Dosing of Aminoglycosides by William A Craig

“…DATA SYNTHESIS: Once-daily dosing was consistently less toxic than more frequent dosing in animals. When human pharmacokinetics were simulated in animals, efficacy of once-daily dosing was similar or enhanced over more frequent dosing regimens. …”
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Analysis of Progress and Challenges of EGFR-Targeted Molecular Imaging in Cancer With a Focus on Affibody Molecules by Weizhi Chen MD, Baozhong Shen MD, PhD, Xilin Sun PhD

“…Small-molecule probes are safe, have favorable pharmacokinetics, and show high affinity and specificity, in addition to having an ideal size, but are inadequate for delayed imaging after injection due to their fast clearance.…”
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Kerala’s fight against Nipah Virus: Surveillance and safety measures intensify by Shriyansh Srivastava, Sharib Raza Khan, Pranav Gupta, Molakpogu Ravindra Babu, Aroop Mohanty, Prakasini Satapathy, Sanjit Sah, Rachana Mehta

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Coverage bias in small molecule machine learning by Fleming Kretschmer, Jan Seipp, Marcus Ludwig, Gunnar W. Klau, Sebastian Böcker

“…Abstract Small molecule machine learning aims to predict chemical, biochemical, or biological properties from molecular structures, with applications such as toxicity prediction, ligand binding, and pharmacokinetics. A recent trend is developing end-to-end models that avoid explicit domain knowledge. …”
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