Fluticasone Propionate in Inflammatory Bowel Disease by Marta Carpani de Kaski, Humphery JF Hodgson

“…This article briefly reviews the pharmacokinetics of corticosteroids and the strategics available for reducing systemic side effects. …”
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Intravenous to Oral Stepdown Antibiotic Therapy: Another Cost-Effective Strategy in an Era of Shrinking Health Care Dollars by Thomas J Louie

“…Although there are gaps in our information base with regards to outcome studies. the application of newer “pharmacodynamic” principles of antimicrobials action and careful selection of antimicrobials based on in vitro activity and pharmacokinetics will maximize the effectiveness of stepdown treatment of infections.…”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…Further in vivo and in vitro pharmacokinetic analyses reveal that obese db/db mice exhibited a diminished capacity to metabolize BBR in their livers. …”
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The Individualized Management Approach for Acute Poisoning by Muneera Al-Jelaify, Suliman AlHomidah

“…Promoting awareness among healthcare professionals managing acute poisoning about the importance of incorporating the pharmacokinetics and following certain criteria to consider interventions such as activated charcoal, antidote, or specific investigations may improve their risk assessment strategies and management plans. …”
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Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography by Andrzej Czyrski

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Vericiguat: A New Hope for Heart Failure Patients by Raquel Chiles, Rami A. Al-Horani

“…In this review, we describe the chemical and mechanistic aspects, pharmacokinetics, adverse effects, and contraindications of vericiguat so as to facilitate its optimal therapeutic use.…”
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats by Laure Balasse, Julia Maerk, Frédéric Pain, Aurelie Genoux, Sylvain Fieux, Françoise Lefebvre, Christian Morel, Pascale Gisquet-Verrier, Philippe Lanièce, Luc Zimmer

“…These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents.…”
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Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System by Pashtoon Murtaza Kasi, Rawad Mounzer, George H. Gleeson

“…Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.…”
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Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature by Jason A. Chen, Katherine M. Unverferth, Erick H. Cheung

“…Unique to this case, delayed-onset seizures occurred in a patient with a relatively low dose of quetiapine and no obvious toxidrome, suggesting that this reaction may be an important consideration in the management of quetiapine overdose. The pharmacokinetics and pharmacodynamics of quetiapine may explain this unusual phenomenon.…”
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Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview by Fitrianti Darusman, Taofik Rusdiana, Iyan Sopyan, Hanifa Rahma, Millati Hanifa

“…This review aims to review and assess the performance of pharmaceutical excipients as P-glycoprotein permeability inhibitors in improving oral drug bioavailability in drug formulations by evaluating meta data from P-glycoprotein efflux in permeability and pharmacokinetics studies. The review results are pharmaceutical excipients that have proven effective as P-glycoprotein inhibitors from the surfactant and polymer groups, namely TPGS and Poloxamer 188, respectively. …”
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Deciphering nifedipine in vivo delivery from modified release dosage forms: Identification of food effect by Ilić Marija, Kovačević Ivan, Parojčić Jelena

“…A detailed survey of publications on nifedipine pharmacokinetics was done and used to identify the magnitude of food effect. …”
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Development of Bioadhesive Microspheres for Oral Bioavailability Enhancement of Berberine Hydrochloride by Ye Zhang, Hongming Liu

“…The objective of this study was to innovatively prepare chitosan-coated alginate/gelatin BBH loaded microspheres and evaluate their pharmaceutical characteristics and pharmacokinetics. The bioadhesive microspheres were prepared using an emulsification technique. …”
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Antibiotic Treatment of Dogs and Cats during Pregnancy by Marcela Rebuelto, María Elena Loza

“…The use of pharmacological agents in pregnant females poses a major clinical challenge due to the marked physiological changes that may modify the pharmacokinetics of drugs and to the potential effects on the fetus. …”
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Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies by Andra Maria Ciutac, Tiberiu Pana, Dana Dawson, Phyo Kyaw Myint

“…Additionally, it takes into consideration the sex-related variation in cardiovascular health and physiology and the role ageing plays in HF and its implications in drug therapy. The pharmacokinetics and pharmacodynamics of the common HF medications, classified according to the established sub-types, are summarised with respect to sex-specific documented findings. …”
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The controversies of parabens – an overview nowadays by Petric Zvonimir, Ružić Julia, Žuntar Irena

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Comparative drug-drug interactions of berberine and astragaloside IV in normal and type 2 diabetes mellitus rats based on UPLC-QqQ-MS/MS by Yan Lei, Jiaqi Xie, Zhongshui Xie, Xiaojun Zhao, Jianmei Huang, Can Wang

“…However, AST had few significant effects on the pharmacokinetic parameters of BBR and the main metabolites in T2DM rats. …”
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Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept by Bernd Raffeiner, Francesca Ometto, Livio Bernardi, Costantino Botsios, Leonardo Punzi

“…The available TNFα blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects. …”
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Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine by Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan

“…Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. …”
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Quercetin nanoparticles as a therapeutic approach: pharmacological actions and potential applications in therapy by Reham Farouk El-Sayed Baiomy

“…This comprehensive review aims to explore the pharmacokinetics and biological activities associated with quercetin nanoparticles. …”
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Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes by Shuang Gao, Yuanyuan Zhang, Kaini Liang, Ran Bi, Yanan Du

“…Moreover, we highlight the importance of understanding the pharmacokinetics (PK) of transplanted cells and discuss the hurdles in MSC-based T2DM therapy toward future clinical applications.…”
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