Mathematical Modeling for Pharmaco-Kinetic and -Dynamic Predictions from Controlled Drug Release NanoSystems: A Comparative Parametric Study by Grigorios P. Panotopoulos, Ziyad S. Haidar

“…Predicting pharmacokinetics, based on the theory of dynamic systems, for an administered drug (whether intravenously, orally, intramuscularly, etc.), is an industrial and clinical challenge. …”
Get full text

Iron(III)–Quercetin Complex: In Vivo Acute Toxicity and Biodistribution of Novel MRI Agent by Innuan P, Kongkarnka S, Thongtharb A, Kantapan J, Dechsupa N

“…Acute toxicity studies showed no mortality, morbidity, or significant biochemical changes, with histopathology confirming no irreversible organ damage. Pharmacokinetics revealed peak blood iron content at 1.1 hours post-administration and clearance within 24 hours. …”
Get full text

To Measure or Not to Measure: Direct Oral Anticoagulant Laboratory Assay Monitoring in Clinical Practice by Tania Ahuja, Veronica Raco, Sharonlin Bhardwaj, David Green

“…Although routine monitoring may be unnecessary given predictable pharmacokinetics in most patients, there may be altered pharmacokinetics in those with end organ dysfunction, such as those with renal impairment, or with concomitant interacting medications, at extremes of body weight or age, or in those with thromboembolic events in atypical locations. …”
Get full text

A CDFT-Based Computational Peptidology (CDFT-CP) Study of the Chemical Reactivity and Bioactivity of the Marine-Derived Alternaramide Cyclopentadepsipeptide by Norma Flores-Holguín, Juan Frau, Daniel Glossman-Mitnik

“…The computational pharmacokinetics study revealed the potential ability of alternaramide as a therapeutic drug by interacting with GPCR ligands and protease inhibitors. …”
Get full text

A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women by Bo Anne Daniëlla Frederique Saals, Tessa Helena De Bie, Eral Osmanoglou, Ties van de Laar, Adriaan Willem Tuin, Anne Claire Benedikte van Orten-Luiten, Renger Frederik Witkamp

“…The registration title is: Determination of Pharmacokinetics and Food-effect of CBD from a Hemp Extract in Healthy Human Volunteers.…”
Get full text

Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection by Tim J. Lamer, Rozalin R. Dickson, Halena M. Gazelka, Wayne T. Nicholson, Joel M. Reid, Susan M. Moeschler, W. Michael Hooten

“…The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided cervical epidural-administered triamcinolone acetonide in a cohort of patients with cervical radicular pain seeking treatment in a pain medicine clinic. …”
Get full text

High Performance Liquid Chromatographic Assay for the Simultaneous Determination of Posaconazole and Vincristine in Rat Plasma by Hadeel A. Khalil, Ahmed F. El-Yazbi, Tarek S. Belal, Dalia A. Hamdy

“…The assay was validated as per ICH guidelines and is appropriate for pharmacokinetics drug-drug interaction studies.…”
Get full text

Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits by Raquel Díez-Láiz, Juan J. García-Vieitez, M. José Diez-Liébana, Matilde Sierra-Vega, Ana M. Sahagún-Prieto, Ángela P. Calle-Pardo, Nélida Fernández-Martínez

“…Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in Cmax, AUC, and tmax in animals fed with fiber. …”
Get full text

Phase 3 Study of Talazoparib Plus Enzalutamide Versus Placebo Plus Enzalutamide as First‐Line Treatment in Patients With Metastatic Castration‐Resistant Prostate Cancer: TALAPRO‐2... by Nobuaki Matsubara, Hideaki Miyake, Hiroji Uemura, Atsushi Mizokami, Hiroaki Kikukawa, Takeo Kosaka, Kazuo Nishimura, Motonobu Nakamura, Kazuki Kobayashi, Atsushi Komaru, Yuko Mori, Shigeyuki Toyoizumi, Natsuki Hori, Yoshiko Umeyama, Hirotsugu Uemura

“…We report an exploratory analysis of efficacy, safety, and pharmacokinetics in Japanese patients enrolled in the TALAPRO‐2 study. …”
Get full text

Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms by Przemysław J. Danek, Władysława A. Daniel

“…., in the dopaminergic nigrostriatal pathway), iloperidone may attenuate extrapyramidal symptoms, while by decreasing the CYP2D activity and metabolism of neurosteroiods in the frontal cortex and cerebellum, iloperidone can have beneficial effects in the treatment of schizophrenia. In the liver, pharmacokinetic interactions involving chronic iloperidone and CYP2D substrates are likely to occur.…”
Get full text

Mannitol and the blood-labyrinth barrier by Trung N. Le, Brian W. Blakley

“…Our goal was to simultaneously assess the pharmacokinetics of gentamicin in each of three different fluid samples in the same animal. …”
Get full text

The In Vivo Evaluation on Total Components from Extract of Aconitum Based on a New Analytic Method of Area under Absorbance-Wavelength Curve by Miaomiao Yang, Huasong Wu, Xiaodong Li

“…Results. The pharmacokinetic parameters of single and multiple doses were similar, and both of them showed characteristics of the one-compartment model. …”
Get full text

Renal Aspects of Peptic Ulcer Pharmacology by Daniel Muruve, Ellen Burgess

“…Similarly, renal dysfunction may alter the pharmacokinetics of this diverse group of medications resulting in dosage adjustments. …”
Get full text

Bimodal Solutions or Twice-Daily Icodextrin to Enhance Ultrafiltration in Peritoneal Dialysis Patients by Periklis Dousdampanis, Konstantina Trigka, Joanne M. Bargman

“…In this paper, we will discuss the pharmacokinetics and biocompatibility of icodextrin and its clinical effect on fluid management in peritoneal dialysis patients. …”
Get full text

Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…Further, %inhibition of platelet aggregation from AT-10 treatment in poor metaboliser group was significantly higher than the clopidogrel treatments in extensive metaboliser group.Overall pharmacokinetic comparison in all subjects indicates that AT-10 gives greater exposure to active Metabolite H4 than clopidogrel.Conclusion AT-10 showed better inhibition of platelet aggregation in poor metabolizers as compared to Clopidogrel. …”
Get full text

Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study by Mirjam Tielen, Job van Exel, Mirjam Laging, Denise K. Beck, Roshni Khemai, Teun van Gelder, Michiel G. H. Betjes, Willem Weimar, Emma K. Massey

“…Moreover, the intrapatient variability in the pharmacokinetics of tacrolimus was calculated, which measures stability of drug intake. …”
Get full text

CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Acellbia is non-inferior to MabThera in terms of efficacy, pharmacokinetics, pharmacodynamics and immunogenicity. …”
Get full text

Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review by Asmaa Ibrahim, Kazeem Yusuff, Ahmed Awaisu, Hazem Elewa

“…Proton pump inhibitors (PPIs) are widely prescribed medications for the management of acid-related disorders, due to their effectiveness and favorable pharmacokinetics. However, the occurrence and severity of adverse drug reactions (ADRs) in patients using PPIs, particularly in relation to their association with CYP2C19 polymorphisms, are of great concern. …”
Get full text

Theophylline Revisited. Mechanisms, Challenges, and New Horizons by Jakub Szarłowicz, Michał Mazur, Dorota Waz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…Materials and Methods A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine. …”
Get full text

Epidemiology and Risk Factor Analysis of Systemic Allergic Reaction to Bee Venom in the Slovenian Population of Beekeepers by CARLI Tanja, LOCATELLI Igor, KOŠNIK Mitja, BEVK Danilo, KUKEC Andreja

Get full text