Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions by Chang Shao, Shuo Tang, Siqin Yu, Chenguang Liu, Yueyang Zhang, Tianyan Wan, Zimeng He, Qi Yuan, Shihan Wu, Hanqing Zhang, Ning Wan, Mengru Zhan, Ren Xiang Tan, Haiping Hao, Hui Ye, Nanxi Wang

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The Comorbidity of Depression and Diabetes Is Involved in the Decidual Protein Induced by Progesterone 1 (Depp1) Dysfunction in the Medial Prefrontal Cortex by Chen Xu, Mengxing Liao, Shize Zhang, Yuang Chen, Xinyue Shulai, Guangji Wang, Jiye Aa

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Is the GFR‐based scaling approach adequate for predicting pediatric renal clearance of drugs with passive tubular reabsorption? Insights from PBPK modeling by Sanwang Li, Xuexin Ye, Qiushi Wang, Zeneng Cheng, Feiyan Liu, Feifan Xie

“…Pediatric physiologically based pharmacokinetic (PBPK) modeling of metronidazole revealed that using a GFR‐based scaling method (Johnson model) significantly overestimated drug concentrations in children under 2 months, whereas utilizing the Mech‐KiM model for renal clearance predictions yielded estimates closely aligned with observed concentrations. …”
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Development and Application of <i>Lactobacillus plantarum</i> PSCPL13 Probiotics in Olive Flounder (<i>Paralichthys olivaceus</i>) Farming by Muhammad Aleem Abbas, Hae-Jung Kim, Ga-Yeong Lee, Hae-Yeon Cho, Syed Al Jawad Sayem, Eon-Bee Lee, Seung-Jin Lee, Seung-Chun Park

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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…Consequently, a new pepsin digestion-based liquid chromatography-tandem mass spectrometry (LC/MS/MS) method was successfully developed to support the mouse pharmacokinetic (PK) sample analysis. In brief, robust and reproducible C-terminal cleavage of both leucine and phenylalanine near the double mutation site of the mutated mIgG2a was accomplished at pH ≤2 and 37°C. …”
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Macrophage Heterogeneity in Respiratory Diseases by Carian E. Boorsma, Christina Draijer, Barbro N. Melgert

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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics by Guangqing Xiao, Liang-Shang Gan

“…In addition, the role of neonatal Fc receptor (FcRn) in regulating the efflux of Immunoglobulin G (IgG) from brain to blood, and approaches to improve the pharmacokinetics of therapeutic biologics by generating Fc fusion proteins, and increasing the pH dependent binding affinity between Fc and FcRn, are discussed.…”
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A Novel Liquid Chromatography–Tandem Mass Spectrometry Method to Quantify Tryptophan and Its Major Metabolites in Serum to Support Biomarker Studies in Patients with Cancer Undergo... by Anna Siemiątkowska, Barbara Kuźnar-Kamińska, Katarzyna Kosicka-Noworzyń, Kamila Nowaczewska, Hanna Winiarska, Dominika Popiołek, Filip Kamiński, Franciszek K. Główka

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T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics by Ruoxuan Sun, Mark G. Qian, Xiaobin Zhang

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11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia by Katarzyna Kosicka, Anna Siemiątkowska, Franciszek K. Główka

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The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography by Andrzej Czyrski, Bartłomiej Kupczyk

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A model‐based approach using GSK3772847, an anti‐interleukin‐33 receptor monoclonal antibody, as a showcase to predict SC administration PK and free target dynamics based on PK and... by Jan Berkhout, Dave Fairman, Martijn vanNoort, Tamara J. vanSteeg

“…Abstract Integrated modeling of the pharmacokinetic (PK) and target binding, by means of a TMDD model, can provide valuable insights into the expected pharmacodynamic (PD) effects of monoclonal antibodies (mAbs). …”
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Pharmacodynamic Profiling of Amoxicillin: Targeting Multidrug-Resistant Gram-Positive Pathogens <i>Staphylococcus aureus</i> and <i>Staphylococcus pseudintermedius</i> in Canine Cl... by Syed Al Jawad Sayem, Ga-Yeong Lee, Muhammad Aleem Abbas, Seung-Chun Park, Seung-Jin Lee

“…<b>Background/Objectives</b>: This study evaluates the effectiveness of amoxicillin against these MDR pathogens in canine isolates using pharmacokinetic and pharmacodynamic parameters. <b>Methods</b>: Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and mutation prevention concentration (MPC) were assessed. …”
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Characterization of Macrophage Phenotypes in Three Murine Models of House-Dust-Mite-Induced Asthma by Christina Draijer, Patricia Robbe, Carian E. Boorsma, Machteld N. Hylkema, Barbro N. Melgert

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Oral supplementation with propionate is reflected in the serum of healthy individuals by Maximilian Schröder, Arijan Pasic, Frank Hirche, Svitlana Rozanova, Melissa Sgodzai, Barbara Gisevius, Lea Horstkemper, Ralf Gold, Katrin Marcus, Kalliopi Pitarokoili, Jeremias Motte, Katalin Barkovits, Gabriele Stangl, Anna Lena Fisse

“…Conclusion: The shown pharmacokinetics can be used in future PA research.…”
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Improving breast cancer treatments using pharmacomicrobiomics by Aswin Anand Pai, Aadra Prashant Bhatt

“…Alam et al. introduce gut microbiota as a key factor influencing tamoxifen pharmacokinetics (Y. Alam, S. Hakopian, L. Ortiz de Ora, I. …”
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Intra- and Interspecies Conjugal Transfer of Plasmids in Gram-Negative Bacteria by Julia R. Savelieva, Daria A. Kondratieva, Maria V. Golikova

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Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system by Felicijan Tjaša, Bogataj Marija

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Pramipexole Extended Release: A Novel Treatment Option in Parkinson's Disease by Wolfram Eisenreich, Bernd Sommer, Sebastian Hartter, Wolfgang H. Jost

“…The present study summarizes pharmacokinetics and all essential pharmacological and clinical characteristics of the extended-release formulation. …”
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Biopharmaceutical classification of desloratadine – not all drugs are classified the easy way by Berginc Katja, Sibinovska Nadica, Žakelj Simon, Trontelj Jurij, Legen Igor

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