Sex and gender differences in pain perception and management in clinical settings by Jakara Morgan, Krystal Magwood, Joslyn Smith, Marjorie R. Jenkins, Alyson J. McGregor, Kelly M. Quesnelle

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Choosing the Right Angiotensin Converting Enzyme Inhibitors; Gender –Specific Approach by Neena Elsa Varghese, K. Jegaveerapandi, Goutham Yerrakula

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A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

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Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies by Armin Sepp, Morris Muliaditan

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Optimal timing for lithium levels [version 2; peer review: 2 approved, 1 approved with reservations] by Kevin J Black

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stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments by Roberto Visintainer, Anna Fochesato, Anna Fochesato, Daniele Boaretti, Stefano Giampiccolo, Stefano Giampiccolo, Shayne Watson, Micha Levi, Federico Reali, Luca Marchetti, Luca Marchetti

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Editorial: Insights in pharmacogenetics and pharmacogenomics: 2023 by José A. G. Agúndez, Elena García-Martín

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Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extracts by Hailong Xie, Dongxue Wang, Wenjun Zhang, Xinjia Yan, Ying Zhao

“…This validated method was successfully employed to investigate the pharmacokinetics of the four ginsenosides in rat plasma after oral administration of PQ-AG and PQ extracts. …”
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Quantitative analysis and pharmacokinetic study of a novel diarylurea EGFR inhibitor (ZCJ14) in rat plasma using a validated LC-MS/MS method by Zuo Sai-Jie, Cheng Xiao-Liang, Liu Dong-Zheng, Feng Wei-Yi, Cao Yong-Xiao, Zhang San-Qi

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Simultaneous Determination of Five Chromones of Radix Saposhnikoviae Extract in Rat Plasma by UPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Febrile Rats by Li Meng, Hui Gao, Bin Chen, Peng-peng Liu, Guo-shun Shan, Fan Zhang, Tian-zhu Jia

“…The results showed that the pharmacokinetic behavior of RS extract significantly differed between the two types of rats.…”
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Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats by Yu-Qiang Liu, Qian Cai, Chang Liu, Feng-Wei Bao, Zhen-Qiu Zhang

“…The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. …”
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Effectiveness of PK-Guided Personalized Recombinant FVIII Treatment in Patients with Hemophilia A: Clinical Case Experiences Based on an Observational Study by Mizoguchi Y, Hino M, Ueda H, Miyaguchi Y, Kobayashi M

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Antenatal corticosteroids in Singapore: a clinical and scientific assessment by Arundhati Gosavi, Zubair Amin, Sean William David Carter, Mahesh Arjandas Choolani, Erin Lesley Fee, Mark Amir Milad, Alan Hall Jobe, Matthew Warren Kemp

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Simultaneous Determination of Six Components in Beagle Dog Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study of Three Different Yuanhu Zhitong Preparations by Yang Wang, Zhaorui Yin, Kai Zhang, Qingfen Meng, Jianli Guan, Guanwei Fan

“…After oral administration, the pharmacokinetic characteristics of the three YHZT preparations were different. …”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…Conclusion Multiple doses of NX210c exhibited a good safety profile, showed non-cumulative pharmacokinetics, and exerted pharmacodynamic effects on biomarkers linked to BBB integrity. …”
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Promising role of voxelotor in managing sickle cell disease in children: a narrative review by Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua

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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

Subjects: “…Target pharmacology, Antibodies, Pharmacokinetics, High-throughput ML, Decision tree classification.…”
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UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans by Jin-Woo Park, Jin-Woo Park, Jin-Woo Park, Jong-Min Kim, Young Yoon Bang, Kyoung-Ah Kim, Sungwook Yu, Ji-Young Park

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Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

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