Beetroot (Beta vulgaris L.) Extract Ameliorates Gentamicin-Induced Nephrotoxicity Associated Oxidative Stress, Inflammation, and Apoptosis in Rodent Model by Ali A. El Gamal, Mansour S. AlSaid, Mohammad Raish, Mohammed Al-Sohaibani, Shaza M. Al-Massarani, Ajaz Ahmad, Mohamed Hefnawy, Mohammed Al-Yahya, Omer A. Basoudan, Syed Rafatullah

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Association between Chronic Pain and Diabetes/Prediabetes: A Population-Based Cross-Sectional Survey in Saudi Arabia by Khaled K. Aldossari, Mamdouh M. Shubair, Jamaan Al-Zahrani, Abdulrahman A. Alduraywish, Khalid AlAhmary, Salwa Bahkali, Sara M. Aloudah, Sami Almustanyir, Laila Al-Rizqi, Sally A. El-Zahaby, Paivi Toivola, Ashraf El-Metwally

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Knowledge, Attitude, and Practice Towards Responsible Self-Medication Among Pharmacy Students: A Web-Based Cross-Sectional Survey in Uganda by Brian B, Goruntla N, Bommireddy BR, Mopuri BM, Easwaran V, Mantargi MJS, Thammisetty DP, Bukke SPN, Yadesa TM, Ayogu EE

“…Bukoli Brian,1 Narayana Goruntla,1 Bhavana Reddy Bommireddy,2 Bhavani M Mopuri,2 Vigneshwaran Easwaran,3 Mohammad Jaffar Sadiq Mantargi,4 Durga Prasad Thammisetty,5 Sarad Pawar Naik Bukke,6 Tadele Mekuriya Yadesa,1 Ebere Emilia Ayogu7 1Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy, Kampala International University, Western Campus, Ishaka, Uganda; 2Research Scholar, Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, Anantapur, AP, India; 3Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia; 4Department of Pharmacology, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia; 5Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi, AP, India; 6Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Kampala International University, Western Campus, Ishaka, Uganda; 7Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, NigeriaCorrespondence: Narayana Goruntla; Bukoli Brian, Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy, Kampala International University, Western Campus, Ishaka, Uganda, Tel +256760060453, Email narayanagoruntla@gmail.com; drgoruntla@kiu.ac.ug; bukoli.brian@gmail.comPurpose: Rational self-medication (SM) practice among healthcare students is essential to promote the safe, effective, and economical use of medicines for self-diagnosed conditions. …”
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Erectile Function and Sexual Activity Are Declining in the Younger Generation: Results from a National Survey in Japan by Akira Tsujimura, Shinichiro Fukuhara, Koji Chiba, Tsuyoshi Yoshizawa, Hikaru Tomoe, Masato Shirai, Kazunori Kimura, Eiji Kikuchi, Eri Maeda, Yoshikazu Sato, Atsushi Nagai, Koichi Nagao, Haruaki Sasaki

Sexual Practices and HIV Prevention Strategies Used by Female Sex Workers in Lagos, Nigeria: An Assessment of the Willingness to Use a Microbicide by Ekama SO, Sheth AN, Ilomuanya MO, Okwuzu JO, Musa AZ, Idigbe I, Ezeobi PM, Oladele DA, Ezechi OC, Salako BL

“…Sabdat Ozichu Ekama,1 Anandi N Sheth,2 Margaret O Ilomuanya,3 Jane Ogoamaka Okwuzu,1 Adesola Zaidat Musa,1 Ifeoma Idigbe,1 Paschal Mbanefo Ezeobi,1 David Ayoola Oladele,1 Oliver Chukwujekwu Ezechi,1 Babatunde Lawal Salako1 1Clinical Sciences Department, Nigerian Institute of Medical Research, Yaba, Lagos, P.M.B 2013, Nigeria; 2Department of Medicine, Division of Infectious Diseases, Emory School of Medicine, Atlanta, GA, USA; 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, Lagos, Surulere, P.M.B 12003, NigeriaCorrespondence: Sabdat Ozichu Ekama, Clinical Sciences Department, Nigerian Institute of Medical Research, 6 Edmund Crescent, Yaba, Lagos, P.M.B 2013, Nigeria, Tel +2348033220908, Email sabdatekama@gmail.comBackground: Female sex workers have a 13-fold higher risk of acquiring HIV than women who do not engage in sex work. …”
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Local Exosome Inhibition Potentiates Mild Photothermal Immunotherapy Against Breast Cancer by Qian Chen, Yanan Li, Jiameng Hu, Zhenyu Xu, Shengyi Wang, Naicong Cai, Mengjiao He, Yifang Xiao, Yuan Ding, Mengjuan Sun, Chunjiayu Li, Yiyang Cao, Zhongyuan Wang, Fang Zhou, Guangji Wang, Chen Wang, Jiasheng Tu, Haiyang Hu, Chunmeng Sun

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Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

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An active shrinkage and antioxidative hydrogel with biomimetic mechanics functions modulates inflammation and fibrosis to promote skin regeneration by Tao Zhang, Xin-Cao Zhong, Zi-Xuan Feng, Xiao-Ying Lin, Chun-Ye Chen, Xiao-Wei Wang, Kai Guo, Yi Wang, Jun Chen, Yong-Zhong Du, Ze-Ming Zhuang, Yong Wang, Wei-Qiang Tan

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Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 by Wenhua Kuang, Ruishen Zhuge, Ping Song, Letai Yi, Shujie Zhang, Ying Zhang, Yin Kwan Wong, Ruixing Chen, Junzhe Zhang, Yuanbo Wang, Dandan Liu, Zipeng Gong, Peili Wang, Xiangying Ouyang, Jigang Wang

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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

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Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

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Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

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Grand Challenges at the Interface of Engineering and Medicine by Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller

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Drug Disposal and Ecopharmacovigilance Practices in the Krowor Municipality, Ghana by Yvonne Yirenkyiwaa Esseku, Priscilla Kolibea Mante, Alex Nii Oto Dodoo, Eric Woode

“…In the delivery of healthcare, medicines may remain unused and may expire within the various stakeholders in the pharmaceutical value chain. If these unused and expired medicines are not disposed of properly, they may result in the concentration of pharmaceuticals in environmental media contaminating food sources for humans and animals. …”
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Relationship between External Environment, Internal Conditions, and Digital Transformation from the Perspective of Synergetics by Xiaowen Luo, Shun-Chi Yu

“…As the digital technologies develop, traditional pharmaceutical enterprises have also begun the exploration of digital transformation (DT). …”
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Elimination of metoclopramid by the adsorption process (GAC) and ozone process by Oussama Khemis, Gabriel Racovițeanu, Elena Vulpașu

“…Existence of pharmaceutical substances in water with different concentrations in natural ecosystems it poses a danger to humans and animals. …”
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Challenges and Current Trends in Preventing Antimicrobial Resistance in EU Water Law Context by Justyna Rogowska, Grażyna Gałęzowska, Agnieszka Zimmermann

“…The increasing consumption of pharmaceuticals, including antibiotics, and their improper disposal have resulted in both pharmaceuticals and their metabolites being released into the environment, where they pose a risk to both ecosystems and human health. …”
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Analytical Quality by Design: A Tool for Regulatory Flexibility and Robust Analytics by Ramalingam Peraman, Kalva Bhadraya, Yiragamreddy Padmanabha Reddy

“…It is a current trend among pharmaceutical industry to implement analytical quality by design (AQbD) in method development process as a part of risk management, pharmaceutical development, and pharmaceutical quality system (ICH Q10). …”
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