Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy by Shinji Kume, Takashi Uzu, Keiji Isshiki, Daisuke Koya

“…New therapeutic strategies are needed to prevent the onset of diabetic nephropathy. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostases. …”
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Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism by Sander Kersten

“…An important group of transcription factors that mediates the effect of dietary fatty acids and certain drugs on plasma lipoproteins are the peroxisome proliferator activated receptors (PPARs). Three PPAR isotypes can be distinguished, all of which have a major role in regulating lipoprotein metabolism. …”
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Peroxisome Proliferator-Activated Receptors in Lung Cancer by Venkateshwar G. Keshamouni, ShouWei Han, Jesse Roman

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. …”
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Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity by Silvia Martina Ferrari, Poupak Fallahi, Roberto Vita, Alessandro Antonelli, Salvatore Benvenga

“…Peroxisome proliferator-activated receptor- (PPAR-) γ expression has been shown in thyroid tissue from patients with thyroiditis or Graves’ disease and furthermore in the orbital tissue of patients with Graves’ ophthalmopathy (GO), such as in extraocular muscle cells. …”
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Peroxisome Proliferator-Activated Receptors and Acute Lung Injury by Rosanna Di Paola, Salvatore Cuzzocrea

“…Peroxisome proliferator-activated receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. …”
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Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility by Maurizio Vitti, Giovanna Di Emidio, Michela Di Carlo, Gaspare Carta, Andrea Antonosante, Paolo Giovanni Artini, Annamaria Cimini, Carla Tatone, Elisabetta Benedetti

“…Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs) activation. PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer by Joo-In Park, Jong-Young Kwak

“…Among these receptors, special attention has been focused on the role of peroxisome proliferator-activated receptors (PPARs) in colorectal cancer, because PPARs are involved in regulation of lipid and carbohydrate metabolism. …”
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Peroxisome Proliferator-Activated Receptor Alpha Target Genes by Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten

“…The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. …”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes. …”
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A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis? by Barrie J. Anthony, Jeremy T. Allen, Yuesheng S. Li, Donald P. McManus

“…Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease by Rachel E. Nisbet, Roy L. Sutliff, C. Michael Hart

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. …”
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The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes by M. C. Thomas, K. A. Jandeleit-Dahm, C. Tikellis

“…Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. …”
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The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer by Runzhi Huang, Jiaqi Zhang, Mingxiao Li, Penghui Yan, Huabin Yin, Suna Zhai, Xiaolong Zhu, Peng Hu, Jiaxin Zhang, Ling Huang, Man Li, Zehui Sun, Tong Meng, Daoke Yang, Zongqiang Huang

“…Peroxisome proliferator-activated receptors (PPARs) are members of nuclear transcription factors. …”
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Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration by Chi-Chao Chan, Jingsheng Tuo, Alexandra A. Herzlich

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Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases by Francisco A. Monsalve, Radha D. Pyarasani, Fernando Delgado-Lopez, Rodrigo Moore-Carrasco

“…Individuals with these characteristics commonly manifest a prothrombotic state and a proinflammatory state as well. Peroxisome proliferator-activated receptors (PPARs) may serve as potential therapeutic targets for treating the metabolic syndrome and its related risk factors. …”
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Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition by Valerie Borel, Denis Gallot, Geoffroy Marceau, Vincent Sapin, Loïc Blanchon

“…Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the placentation. …”
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Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease by Jean Dallongeville, Carlos Iribarren, Jean Ferrières, Liisa Lyon, Alun Evans, Alan S. Go, Dominique Arveiler, Stephen P. Fortmann, Pierre Ducimetière, Mark A. Hlatky, Philippe Amouyel, Audrey Southwick, Thomas Quertermous, Aline Meirhaeghe

“…Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor γ (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. …”
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Peroxisome Proliferator-Activated Receptor Agonists: Do They Increase Cardiovascular Risk? by Ahmad Aljada, Kshitij Ashwin Shah, Shaker A. Mousa

“…The peroxisome proliferator-activated receptor (PPAR) agonists have a significant role on glucose and fat metabolism. …”
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Peroxisome Proliferator-Activated Receptors in the Modulation of the Immune/Inflammatory Response in Atherosclerosis by Ana Z. Fernandez

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Peroxisome Proliferator-Activated Receptor β/δ in the Brain: Facts and Hypothesis by M. G. Hall, Laure Quignodon, Béatrice Desvergne

“…peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting as lipid sensors. …”
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