Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses by Sarah Buddle, Leysa Forrest, Naomi Akinsuyi, Luz Marina Martin Bernal, Tony Brooks, Cristina Venturini, Charles Miller, Julianne R. Brown, Nathaniel Storey, Laura Atkinson, Timothy Best, Sunando Roy, Sian Goldsworthy, Sergi Castellano, Peter Simmonds, Heli Harvala, Tanya Golubchik, Rachel Williams, Judith Breuer, Sofia Morfopoulou, Oscar Enrique Torres Montaguth

“…Results Capture with the Twist CVRP increased sensitivity by at least 10–100-fold over untargeted sequencing, making it suitable for the detection of low viral loads (60 genome copies per ml (gc/ml)), but additional methods may be needed in a diagnostic setting to detect untargeted organisms. …”
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Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…The main outcomes were the reduction of blood pressure and safety outcomes. Analyses were per intention to treat. Results A total of 90 eligible participants were randomized between July 13, 2022, and April 20, 2023. …”
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Age-related features of some plasminogen activation system components content and activity in the blood of benign and malignant uterine body tumors by I. V. Kaplieva, G. V. Zhukova, V. R. Zakharchenko, E. M. Frantsiyants, E. V. Verenikina, Yu. A. Pogorelova, P. S. Kachesova, Yu. Yu. Kozel, N. A. Maximova, M. G. Ilchenko, E. I. Agarkova, A. S. Egorova

“…There was an increase in the calculated t-PA index (activity per unit mass) by 1.4–2.8 times (p < 0.05) in the most patients. …”
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N-acetylcysteine increased the growth performance of Leuciscus waleckii by improving mitochondrial function, enhancing antioxidant and anti-inflammatory, and inhibiting apoptosis i... by Deng Lai Li, Rui Zhu, Si Tong Meng, Yin Tao Wang, Si Ying Liu, Zhi Yong Yang, Li Fang Wu

“…The results revealed that 3 g/kg-6 g/kg NAC increased FW, WGR, SGR, PER, and FER and improved growth performance and feed utilization in Leuciscus waleckii. 4.50 g/kg-6.00 g/kg NAC increased the intestinal and hepatopancreatic digestive enzyme activities, enhancing digestive function. 3.00 g/kg-4.50 g/kg NAC increased serum ACP and AKP activities, decreased IL-1β and TNF-α levels, and optimized serum biochemical indices in Leuciscus waleckii. …”
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Food-related behaviors of rural (Asaase Kooko) and peri-urban (Kaadjanor) households in Ghana by Prince Kwabena Osei, Megan A. McCrory, Matilda Steiner-Asiedu, Edward Sazonov, Mingui Sun, Wenyan Jia, Tom Baranowski, Gary Frost, Benny Lo, Alex Kojo Anderson

“…The most prevalent occupation in rural households was farming, while in per-urban households, blue-collar jobs (e.g., beauticians, sales personnel, and commercial drivers) were the main occupations. …”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Participants trained with the platform for a median (range) of 11 (1-58) hours, equating to 94 min extra per week. The mean satisfaction score was 34.9 out of 40.Conclusion The Neurofenix platform is safe, feasible and well accepted as an adjunct to usual care in acute and subacute stroke rehabilitation. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…The crude 15-year prevalence of dementia was 2.1%, and the age–sex standardised incidence rate of dementia was 4.3 (95% CI: 4.2 to 4.4) per 1000 person-years. Among the adjusted covariates, CD4 cell count<50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. …”
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Assessing learning, behaviour, and stress level in goats while testing a virtual fencing training protocol by L. Wilms, D. Hamidi, C.H.U. Lüntzel, M. Hamidi, M. Komainda, R. Palme, J. Isselstein, S. Waiblinger, M. Egerbacher

“…The experiment lasted 4 h per day. During this time, the following behaviours were recorded via instantaneous scan sampling of all goats every 2 min: grazing, lying, standing, standing vigilant, walking, and running. …”
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Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…Methods We conducted a proteomic analysis of PBMCs from patients with T1DM and relapsing remitting Multiple Sclerosis (herein forth MS) patients (n = 9 per condition), using a label-free quantitative proteomics approach. …”
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Robotic Versus Open Pancreatoduodenectomy With Vein Resection and Reconstruction: A Propensity Score-Matched Analysis by Niccolò Napoli, MD, PhD, FEBS, Emanuele Federico Kauffmann, MD, PhD, FEBS, Michael Ginesini, MD, Armando Di Dato, MD, Virginia Viti, MD, Cesare Gianfaldoni, MD, Lucrezia Lami, MD, Carla Cappelli, MD, Maria Isabella Rotondo, MD, Daniela Campani, MD, Gabriella Amorese, MD, Caterina Vivaldi, MD, Silvia Cesario, MD, Laura Bernardini, MD, Enrico Vasile, MD, Fabio Vistoli, MD, PhD, FEBS, Ugo Boggi, MD, FEBS

“…Of the 151 patients with PD-VR (open = 115, robotic = 36), 35 procedures per group were compared. Elective conversion to open surgery was required in 1 patient with robotic PD-VR (2.9%). …”
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Dietary protein intake and PM2.5 on ovarian cancer survival: A prospective cohort study by He-Li Xu, Yi-Fan Wei, Qi Bao, Ya-Li Wang, Xiao-Ying Li, Dong-Hui Huang, Fang-Hua Liu, Yi-Zi Li, Yue-Yang Zhao, Xin-Xin Zhao, Qian Xiao, Song Gao, Ren-Jie Chen, Ling Ouyang, Xia Meng, Xue Qin, Ting-Ting Gong, Qi-Jun Wu

“…A positive association between PM2.5 exposure and all-cause mortality was observed (HR=1.52; 95 % CI: 1.13–2.05, per interquartile range increment). Notably, dietary fish, egg, and fruit/vegetable protein modified these associations, as patients with lower intakes had significantly higher PM2.5-related mortality in the cohort (all P for interaction < 0.05). …”
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Cross-cultural adaptation of the simple Chinese version of the medication adherence reasons scale in patients undergoing adjuvant endocrine therapy for breast cancer by Lei Xu, Ping Li, Yan Hu, Weijie Xing, Jiajia Qiu, Xiaoju Zhang, Lingying Jia, Feng Jing, Ye Liu, Lili Li, Chunyang Lu

“…The sample size for exploratory factor analysis (EFA) was determined based on a ratio of five to ten participants per scale item to ensure sufficient statistical power. …”
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Reproductive performance of female largemouth bass (Micropterus salmoides) broodstock was enhanced by dietary small peptides by Jie Wei, Mingwei Tao, Jiaming Huang, Hangxian Zhou, Qiyou Xu

“…To research the effects of dietary small peptides on the reproductive performance of largemouth bass (Micropterus salmoides) broodstock, four isonitrogenous and isolipidic diets were prepared by adding 5 % small peptide (SP) on two fish meal levels (40 and 20 %), which were labeled as HF (40 % FM), HS (40 % FM+5 % SP), LF (20 % FM) and LS (20 % FM+5 % SP), respectively. 160 female largemouth bass broodstock (initial body weight: 452.36 ± 15.54 g) were randomly allocated to four groups with 4 tanks per group of 10 fish each. A 30-day feed experiment was conducted. …”
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Modeling feed efficiency over productive lifetime and integrating a submodel for body reserve management in Nordic dairy cattle by R.B. Stephansen, J. Lassen, V.M. Thorup, B.G. Poulsen, J. Jensen, G. Sahana, O.F. Christensen

“…Our analysis indicated that improving gRFI with one genetic SD unit corresponded to a 2% to 3% gain in net return profit per cow-year, with no or minimal impact on production and body reserve management. …”
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Peculiarities of ambulatory blood pressure monitoring in patients who have suffered from COVID-19 by V.O. Zbitnieva, O.B. Voloshyna, I.V. Balashova, E.A. Zubok, O.R. Dukova, L.I. Kovalchuk

“…In patients with a history of AH, in 55.3% of cases there was observed an increase in average blood pressure values per day, during the day and night periods, which was considered as ineffective blood pressure control and required an increase in the doses of previously prescribed antihypertensive drugs or the use of additional antihypertensive drugs in the treatment regimen. …”
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Assessing the Effectiveness of Interactive Robot-Assisted Virtual Health Coaching for Health Literacy and Disease Knowledge of Patients with Chronic Kidney Disease: Quasiexperiment... by Nai-Jung Chen, Ching-Hao Chang, Chiu-Mieh Huang, Fen-He Lin, Li-Ting Lu, Kuan-Yi Liu, Chih-Lin Lai, Chin-Yao Lin, Yi-Chou Hou, Jong-Long Guo

“…The intervention involved a 12-unit program, with each unit lasting approximately 20 minutes to 30 minutes and delivered across 3 to 4 learning sessions, and participants completed 3 to 4 units per session. The program addressed key aspects of CKD-specific health literacy including functional, communicative, and critical literacy and CKD-specific knowledge including basic knowledge, prevention, lifestyle, dietary intake, and medication. …”
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Dynamics of epidemiological indicators of glaucoma in the Republic of Bashkortostan for the period of 2010–2016 by M.M. Bikbov, A.E. Babushkin, I.I. Khusnitdinov, L. Kh. Murova, E.N. Matyukhina

“…<br> <b>Conclusion</b>: comparative analysis over 2010 and 2016 showed that in the RB over the seven specified years, the number of patients with glaucoma increased from 24,536 to 30,508 people, while the prevalence and incidence of the most frequently diagnosed POAG increased from 114.6 to 168.3 and from 12.9 to 17.5, respectively (per 10 thousand of population in people over 40). …”
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Enhanced Safety and Efficacy of O‐Arm Navigation Over C‐Arm Guidance in Percutaneous Kyphoplasty for Patients With Osteoporotic Vertebral Compression Fractures and Spinal Deformity... by Zhong‐Wei Ji, Min‐Jie Shen, Jia‐Jia Sun, Jia‐Le Wang, Yong‐Kang Deng, Yao Zhang, Xie‐Xing Wu, Kang‐Wu Chen, Hai‐Qing Mao

“…The O‐arm navigation group showed a significant reduction in puncture adjustment per vertebrae, single‐segment operation time, and the rate of trocar needle malposition compared to the C‐arm guidance group. …”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…This made an incremental cost-effectiveness ratio (ICER) calculation irrelevant. Total per-patient costs were CHF 138,894 for the full sotorasib dose, CHF 82,741 for the one-quarter dose, and CHF 80,383 for docetaxel. …”
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Time-series analysis on relationship between short-term exposure to atmospheric ozone and the risk of non-accidental deaths in Hefei during 2017−2020 by Linling YU, Yu ZHU, Changchun XIAO

“…For the O3-8 h concentration per 10 μg·m−3 increase, the single-day effect and cumulative lag effect on NAD among residents reached their maximum values at lag0 and lag02, respectively, with the NAD increasing by 0.46% (95%CI: 0.06%, 0.87%) and 0.76% (95%CI: 0.27%, 1.26%); the maximum estimates for deaths from circulatory diseases appeared on lag03 increasing by 0.78% (95%CI: 0.08%, 1.48%). …”
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