Is first-line treatment with polatuzumab vedotin–rituximab–cyclophosphamide, doxorubicin and prednisone (pola-R-CHP) for previously untreated diffuse large B-cell lymphoma cost-eff... by Lin Yang, Ting Chen, Qiuling Zhao, Liangliang Dong, Wanfu Zhong, Wenbin Liu, Xiuliang Qiu, Ruyi Huang, Shengqiang Huang, Ruixiang Xie

“…The willingness-to-pay (WTP) threshold was set at triple the 2023 Chinese per capita gross domestic product of US$38 042.49/quality-adjusted life year (QALY). …”
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Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…T-cell receptor (TCR) sequencing was also conducted both in immune competent MM mice and in patients enrolled in a phase 1b trial per a standard 3 + 3 dose escalation schedule. Results Here we show ex vivo and in vivo that proteasome inhibitors (PIs) potentiate reovirus replication in circulating classical monocytes, increasing viral delivery to myeloma cells. …”
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Determinants of tobacco use transitions in smoker nursing students in Catalonia: A prospective longitudinal study by Kenza Laroussy, Esteve Fernández, Yolanda Castellano, Marcela Fu, Antoni Baena, Ariadna Feliu, Armando Peruga, Mercè Margalef, Olena Tigova, Jordi Galimany, Montserrat Puig, Carmen Moreno, Albert Bueno, Antonio López, Judith Roca, Judith Saura, Cristina Martínez

“…We examined transitions in tobacco use patterns between baseline and follow-up among smokers from: 1) daily to nondaily smoking, 2) non-daily to daily smoking, 3) cigarette-only use to polytobacco use, 4) poly-tobacco use to cigarette-only use, 5) between products, 6) reducing consumption by ≥5 cigarettes per day (CPD); and 7) quitting smoking. We applied a Generalized Linear Model with a log link (Poisson regression) and robust variance to identify predictors of reducing cigarette consumption by ≥5 CPD and quitting smoking, obtaining both crude and adjusted (APR) prevalence ratios and their 95% confidence intervals (CIs). …”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…Our patient consumed at least 24 oral nicotine pouches (containing 11 mg nicotine each) per day. We consider the patient's COL4A2 mutation in combination with his substantial nicotine consumption as likely predisposition to multiple ICHs precipitated by stereo‐EEG. …”
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Exploring Dance as a Therapeutic Approach for Parkinson Disease Through the Social Robotics for Active and Healthy Ageing (SI-Robotics): Results From a Technical Feasibility Study by Roberta Bevilacqua, Elvira Maranesi, Marco Benadduci, Gabriella Cortellessa, Alessandro Umbrico, Francesca Fracasso, Giovanni Melone, Arianna Margaritini, Angela La Forgia, Pierpaolo Di Bitonto, Ada Potenza, Laura Fiorini, Carlo La Viola, Filippo Cavallo, Alessandro Leone, Andrea Caroppo, Gabriele Rescio, Mauro Marzorati, Amedeo Cesta, Giuseppe Pelliccioni, Giovanni Renato Riccardi, Lorena Rossi

“…A total of 16 Irish dance–based rehabilitation sessions of 50 minutes were conducted (2 sessions per week, for 8 wks), involving 2 patients at a time. …”
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Empirical estimation of saturated soil-paste electrical conductivity in the EU using pedotransfer functions and Quantile Regression Forests: A mapping approach based on LUCAS topso... by Calogero Schillaci, Simone Scarpa, Felipe Yunta, Aldo Lipani, Fernando Visconti, Gábor Szatmári, Kitti Balog, Triven Koganti, Mogens Greve, Giulia Bondi, Georgios Kargas, Paraskevi Londra, Fuat Kaya, Giuseppe Lo Papa, Panos Panagos, Luca Montanarella, Arwyn Jones

“…Among these interventions, seawater intrusion into coastal aquifers, irrigation with waters containing soluble salts, poor drainage of irrigated lands and of naturally saline soils, stand out. Hotspot analysis per country or Nomenclature of Territorial Units for Statistics (NUTS 0) revealed high topsoil ECe levels occurred in Spain 0.11 %. …”
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Effects of Brackish Water with Different Sodium-Potassium Ratios on Soil Water-Salt Characteristics and Winter Wheat Growth by GAO Weiqiang, ZHANG Tibin, TONG Jiankang, LIU Zhenyuan, LIANG Qing, KUANG Yuxin, CHENG Yu, FENG Hao

“…The T2 treatment enhanced plant height, leaf area per plant and aboveground dry matter mass of winter wheat, and increased the yield by 8.41% (p<0.05) compared to CK; while there was no significant difference in underground dry matter mass among treatments (p>0.05). …”
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Cost-effectiveness analysis of three surgical approaches for parathyroidectomy in secondary hyperparathyroidism patients by Qila Sa, Qila Sa, Yinghui Zhou, Guangming Cheng, Boyuan Nan, Yingnan Feng, Yingnan Feng, Ningyuan Zhang, Ningyuan Zhang, Wantao Xie, Wantao Xie, Wei Zhang

“…The study period is 10 years post-surgery, with a discount rate of 5% per year. Uncertainty in the model was assessed using one-way sensitivity analysis and probabilistic sensitivity analysis (PSA).ResultsThe costs incurred by SHPT patients undergoing sPTX, tPTX, and tPTX+AT within 10 years post-surgery are $7042.54, $9983.00, and $11435.60, respectively, with total utilities generated being 13.23 QALYs, 18.76 QALYs, and 18.69 QALYs. …”
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Image-based analysis of quantitative morphological characteristics of wild potato tubers using the desktop application SeedСounter by K. A. Ivanova, E. G. Komyshev, M. A. Genaev, A. A. Egorova, K. A. Koloshina, N. A. Chalaya, D. A. Afonnikov, A. V. Kochetov, E. V. Rogozina, S. V. Gerasimova

“…The tuber yield from each plant was analyzed using SeedCounter (http://wheatdb.org/seedcounter). The number of tubers per plant was counted; the following characteristics were extracted from the images of individual tubers: length, width, projected area, length to width ratio, сircularity, roundness, rugosity and solidity. …”
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Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway by Chao Ma, Yan Wu, Xinyao Liu, Yi He, Yuan Jia, Pei Chen, Dongqing Yin, Yanzhe Ning, Guoqiang Xing, Zuoli Sun, Hongxiao Jia

“…Sixty male C57BL/6 mice were randomly divided into six groups (n=10 per group): (1) control group, (2) cuprizone (CPZ, a copper chelator that induced demyelination, 0.2% w/w)+saline, (3) CPZ+low-dose SZASD (8.65 g·kg-1·d-1), (4) CPZ+medium-dose SZASD (17.29 g·kg-1·d-1), (5) CPZ+high-dose SZASD (25.94 g·kg-1·d-1), and (6) CPZ+quetiapine (QTP, an atypical antipsychotic that served as a positive treatment control, 10 mg·kg-1·d-1). …”
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Effects of Replacing Inorganic Sources of Copper, Manganese, and Zinc with Different Organic Forms on Mineral Status, Immune Biomarkers, and Lameness of Lactating Cows by Manqian Cha, Xingjun Ma, Yunlong Liu, Shengyang Xu, Qiyu Diao, Yan Tu

“…(Methods) Sixty multiparous Holstein cows (158 ± 26 days in milk; body weight: 665 ± 52 kg; milk yield: 32 ± 7 kg/day) were randomly assigned into one of three dietary treatments (<i>n</i> = 20 per group): (1) MHAC: 50% replacement of sulfate minerals with MHAC forms. (2) AAC: 50% replacement of sulfate minerals with AAC forms. (3) S: 100% sulfate minerals (control). …”
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Socially interactive industrial robots: a PAD model of flow for emotional co-regulation by Fabrizio Nunnari, Dimitra Tsovaltzi , Matteo Lavit Nicora , Matteo Lavit Nicora , Sebastian Beyrodt , Pooja Prajod , Lara Chehayeb , Ingrid Brdar , Antonella Delle Fave , Luca Negri , Elisabeth André, Patrick Gebhard , Matteo Malosio 

“…The empirical results and analysis provides empirical support for the theoretically defined model, and clearly points to the need for data pre-filtering and per-user calibration. The proposed post-processing method helps quantify the parameters needed to control the frequency of intervention of the agent; still leaving the experimenter with a run-time adjustable global control of its sensitivity. …”
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Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS... by Ramakanth Kavuluru, Xuan Wang, Paul Avillach, Florence Bourgeois, Kee Yuan Ngiam, Gabriel A Brat, Isaac Kohane, Tianxi Cai, Yuk-Lam Ho, Yuan Luo, Harrison G Zhang, Kelly Cho, Vincent Benoit, Antoine Neuraz, Chuan Hong, Sehi L'Yi, Griffin Weber, Bryce W Q Tan, Alba Gutiérrez-Sacristán, Clara-Lea Bonzel, Nathan P Palmer, Alberto Malovini, Valentina Tibollo, Meghan R Hutch, Molei Liu, Riccardo Bellazzi, Luca Chiovato, Fernando J Sanz Vidorreta, Trang T Le, William Yuan, Bertrand Moal, Michele Morris, David A Hanauer, Sarah Maidlow, Kavishwar Wagholikar, Shawn Murphy, Hossein Estiri, Adeline Makoudjou, Patric Tippmann, Jeffery Klann, Robert W Follett, Nils Gehlenborg, Gilbert S Omenn, Zongqi Xia, Arianna Dagliati, Shyam Visweswaran, Lav P Patel, Danielle L Mowery, Emily R Schriver, Malarkodi Jebathilagam Samayamuthu, Sara Lozano-Zahonero, Daniela Zöller, Amelia L M Tan, Byorn W L Tan, John H Holmes, Petra Schubert, Brett K. Beaulieu-Jones, Miguel Pedrera-Jiménez, Noelia García-Barrio, Pablo Serrano-Balazote, Andrew South

“…The average C reactive protein rate of change was –4.72 mg/dL vs –4.14 mg/dL per day (p=0.05). The mortality rates within each risk category significantly decreased over time, with the most substantial decrease in the high-risk group (47.1% in March–April 2020 vs 30.8% in November 2020 to January 2021, p&lt;0.001) and a moderate decrease in the intermediate-risk group (21.5% in March–April 2020 vs 14.3% in November 2020 to January 2021, p&lt;0.001).Conclusions Admission profiles of patients hospitalised with SARS-CoV-2 infection did not differ greatly between the first and second waves of the pandemic, but there were notable differences in laboratory improvement rates during hospitalisation. …”
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Potential role of particulate matter in the spreading of COVID-19 in Northern Italy: first observational study based on initial epidemic diffusion by Alessandro Miani, Annamaria Colao, Prisco Piscitelli, Leonardo Setti, Fabrizio Passarini, Gianluigi De Gennaro, Pierluigi Barbieri, Sabina Licen, Maria Grazia Perrone, Andrea Piazzalunga, Massimo Borelli, Jolanda Palmisani, Alessia Di Gilio, Emanuele Rizzo

“…In Milan, the average growth rate before the lockdown was significantly higher than in Rome (0.34 vs 0.27 per day, with a doubling time of 2.0 days vs 2.6, respectively), thus suggesting a basic reproductive number R0&gt;6.0, comparable with the highest values estimated for China.Conclusion A significant association has been found between the geographical distribution of daily PM10 exceedances and the initial spreading of COVID-19 in the 110 Italian provinces.…”
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Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study by Nguyen Thanh Tung, Ching-Huang Lai, Chih-Hong Pan, Wei-Liang Chen, Chung-Ching Wang, Che-Wei Liang, Chi-Yu Chien, Kai-Jen Chuang, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Tran Phan Chung Thuy, Hsiao-Chi Chuang

“…We observed the overall incidence rate of COPD to be 2.51 cases per 100 person-years. The incidence rate was higher in welding workers than in office workers and higher in non-smokers compared to smokers. …”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…Introduction Graft-versus-host disease (GvHD) remains a major complication of allogeneic stem cell transplantation (allo-SCT), affecting 30–70% of patients (representing 800 new patients per year in the UK). The risk is higher in patients undergoing unrelated allo-SCT. …”
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Balance Changes in Adult Cancer Survivors Participating in a 16-Week Therapeutic Yoga Program by Mark J. Miller BS, Daniel C. Hughes PhD, Nydia T. Darby DPT, Tim Calderon MS, Darpan I. Patel PhD, Monica C. Serra PhD, Amelie G. Ramirez Dr. PH, Alexis Ortiz PT, PhD, Gustavo J. Almeida PT, PhD

“…The intervention included therapeutic yoga three times per week for 16 weeks and daily psychosocial support provided via text message. …”
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Relative bioavailability of selenium yeast, selenomethionine, hydroxyl-selenomethionine and nano-selenium for broilers by Guoqing Liu, Guoqing Liu, Sumei Cao, Sumei Cao, Liang Huang, Xuanxu Lin, Zheng Sun, Gang Lin, Liyang Zhang, Lin Lu, Xugang Luo, Xiudong Liao

“…A total of 576 one-day-old Arbor Acres commercial male broilers were randomly assigned to 16 treatments with 6 replicate cages per treatment in a completely randomized design involving a 5 (Se sources: SY, SM, SO, NS and SS) × 3 (added Se levels: 0.15, 0.30 and 0.45 mg Se/kg) factorial design of treatments plus 1 (a Se-unsupplemented control) for 21 d. …”
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Association between left ventricular reverse remodelling and the B-type natriuretic peptide–cGMP cascade after anterior acute myocardial infarction by Satoshi Yasuda, Kunihiro Nishimura, Kensuke Takagi, Hiroyuki Takahama, Naoto Minamino, Masashi Fujino, Satoshi Honda, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Soshiro Ogata, Teruo Noguchi, Takahiro Nakashima, Kenichiro Sawada, Yoshiaki Morita, Kazuhiro Nakao, Hiroyuki Miura, Takamasa Iwai, Marina Arai, Eri Kiyoshige, Kota Murai, Hideo Matama, Shuichi Yoneda

“…The presence of LVRR (HR 0.256; 95% CI 0.081 to 0.809; p=0.028) and peak creatine phosphokinase–myocardial band level (per 100 IU/L) (HR 1.22; 95% CI 1.02 to 1.46; p=0.027) were independent predictors of MACCE after adjusting for age, male sex, infarct size and hypertension. …”
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Therapeutic effectiveness of three commercial anthelmintics against strongylids in buffalo calves (Bubalus bubalis) by David Uzcátegui, Víctor Gutiérrez, María Rodríguez, Andrea González, Alfredo Sánchez

“…Twenty-eight buffalo calves, naturally infected, with a parasite load ≥ 350 eggs per gram of faeces (EPG), and age between 2 and 3 months, with an average weight of 65.9 kgs, were selected. …”
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