Use of standardized nasal and skin decolonization to reduce rates of bacteremia in patients undergoing extracorporeal membrane oxygenation by Madyson Taylor, Russell L Griffin, Jeremey Walker, Catina James, Angela Akinsanya, Mary Duncan, Rachael A Lee

“…Following implementation of decolonization, the overall incidence rate of BSI increased nonsignificantly from 10.7 to 14.0 infections per 1000 ECMO days (aRR 1.09, 95% CI 0.74–1.59). …”
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Changing consumption of resources for respiratory support and short-term outcomes in four consecutive geographical cohorts of infants born extremely preterm over 25 years since the... by Alicia J Spittle, Lex W Doyle, Peter J Anderson, Li Huang, Jeanie L Y Cheong, Alice C Burnett, Anjali Haikerwal, Merilyn Bear, Margaret Charlton, Janet Courtot, Noni Davis, Julianne Duff, Rachel Ellis, Marie Hayes, Elisha Josev, Elaine Kelly, Marion Mcdonald, Emma Mcinnes, Bronwyn Novella, Gillian Opie, Gehan Roberts, Katherine Scott, Penelope Stevens, Anne-marie Turner, Kim M Dalziel, Katherine Lee, Marissa Clark, Joy E Olsen, Rosemarie A Boland, Alice E Stewart, Leah M Hickey

“…Cost-effectiveness ratios describing the average additional days of respiratory support associated per additional survivor were calculated.Results Median duration of any respiratory support increased from 22 days (1991–1992) to 66 days (2016–2017). …”
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Il Ruolo della Leadership Infermieristica in un’Organizzazione Etica e Sostenibile by Sipontina Rita Zerulo, Maria Romilda Filice, Chiara Maddalo, Angelo Pirreco, Federico Ruta, Davide Ulvieri, Bruno Cavaliere

“…Quindi sarebbe opportuno considerare l’etica e la sostenibilità un elemento identitario del management infermieristico e revisionare il sistema formativo ed organizzativo per rendere indissolubile questa relazione. …”
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Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…CQ Public Health Unit (CQPHU) will implement the active surveillance by collecting demographic, clinical, pathological, diagnostic, therapeutic and clinical outcome data from the RACFs based on predefined selection criteria and case report forms as per routine public health practices. Descriptive statistics, univariate and multivariate regression analysis will be conducted to identify the predictors of morbidity and clinical outcomes following infection.Ethics and dissemination The study has been approved by the CQHHS Human Research Ethics Committee (HREC) (reference number HREC/2021/QCQ/74305). …”
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Optimization of the extraction methods and evaluation of the hypoglycemic effect of Adhatoda Zeylanica extracts on artificially induced diabetic mice by Md Fahim Ahmed, Khalid Hasan Raby, Nishat Tasnim, Md Tariful Islam, Mahbub Chowdhury, Zarin Tasnim Juthi, Md Ashik Mia, Lubna Jahan, A.K.M. Zakir Hossain, Shoeb Ahmed

“…RD produced the highest crude extract yield (98.29 g/kg of dried leaf), while MAE was the most effective for vasicine extraction, yielding 2.44 g vasicine per kg dried leaf. High Performance Liquid Chromatography (HPLC) with a diode array detector (DAD) was used to identify and quantify vasicine, a quinazoline alkaloid with known antidiabetic properties. …”
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Extrapolating empirical measurements of wastewater exfiltration from sanitary sewers to estimate watershed-scale fecal pollution loading in urban stormwater runoff by Joshua A. Steele, Adriana González-Fernández, John F. Griffith, Darcy Ebentier McCargar, Sierra Wallace, Kenneth C. Schiff

“…Human fecal pollution loads from exfiltration via subsurface transfer during a storm event were calculated to be 1.5 × 1013 (95% CI: 1.79 × 1012 to 3.59 × 1013) HF183 gene copies per storm. This estimate is similar in scale to the measured mass loading estimates in stormwater for the studied watershed and comparable to independently-measured tracers of sewage. …”
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Radiomics for Predicting the Development of Brain Edema from Normal-Appearing Early Brain-CT After Cardiac Arrest and Return of Spontaneous Circulation by Michael Scheschenja, Eva-Marie Müller-Stüler, Simon Viniol, Joel Wessendorf, Moritz B. Bastian, Jarmila Jedelská, Alexander M. König, Andreas H. Mahnken

“…Feature selection involved reproducibility analysis via ICC and LASSO regression, retaining five features per segmentation method. A logistic regression model for each segmentation method underwent 5-fold cross-validation. …”
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Development and validation of soil test crop response model for beetroot (Beta vulgaris) grown in ultisols of India by Ramasamy Arulmani, Ramasamy Arulmani, Kuppayevalasu Malayappagounder Sellamuthu, Kuppayevalasu Malayappagounder Sellamuthu, Subramaniam Maragatham, Subramaniam Maragatham, Alargarsamy Senthil, Alargarsamy Senthil, Seenapuram Palaniswami Thamaraiselvi, Seenapuram Palaniswami Thamaraiselvi, Palaniappan Malathi, Palaniappan Malathi, Govindaraja Sridevi, Govindaraja Sridevi

“…The Soil analysis crop response - combined Plant Nutrition System model proved that beetroot yield can be increased by 34.74%, in relation to the generally recommended dose This inductive method could save 37, 26 and 34 kg of Nitrogen, Phosphorus and Potassium, respectively when Nitrogen, Phosphorus, Potassium fertilizers are combined with 12.5 t ha-1 FYM as per soil test and targeted yield of beetroot.…”
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Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia by Sarah AlHarbi, Sarah AlHarbi, Areej Taha, Areej Taha, Ahmed Ashi, Ahmed Ashi, Naglla Elimam, Naglla Elimam, Sami Althubaiti, Sami Althubaiti, Sami Althubaiti

“…The median number of surveillance blood draws per patient was 12. Relapse was observed in nine patients. …”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Eligible Patients were randomly assigned (1:1) to receive four cycles (21 days as one cycle) of intravenous carboplatin (area under the curve of 5 mg/mL per min, day 1 of each cycle) and etoposide (100 mg/m² of body-surface area, on days 1–3 of each cycle) with either socazolimab (5 mg/kg, day 1 of each cycle) or matching placebo, following maintenance therapy with socazolimab or placebo. …”
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Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

“…Clinical signs and continuous glucose monitoring data were monitored and guided insulin dose adjustments. A per‐protocol analysis was performed. Results The final dose of IDeg100 in dogs was 1.3 U/kg (median, range, 0.4‐2.2) achieved in 14 days (median, range, 3‐32). …”
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Real-world prognostic factors in autotransplanted multiple myeloma patients with severe renal impairment: study of the Polish Myeloma Study Group by Anna Waszczuk-Gajda, David H. Vesole, Jolanta Małyszko, Artur Jurczyszyn, Tomasz Wróbel, Joanna Drozd-Sokołowska, Piotr Boguradzki, Krzysztof Mądry, Agnieszka Tomaszewska, Jarosław Biliński, Maria Król, Longin Niemczyk, Magdalena Olszewska-Szopa, Wieslaw W. Jedrzejczak, Grzegorz W. Basak

“…Higher albumin concentration (per increase of 1 g/dl) (HR = 0.41, p = 0.03) and melphalan 140 mg/m2 versus higher melphalan doses (HR = 0.86, p = 0.008) were associated with longer PFS. …”
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Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells by Yujing Tao, Yujing Tao, Qun Niu, Qun Niu, Yuanqian Yao, Yuanqian Yao, Kaixin Wang, Kaixin Wang, Haijian Dong, Haijian Dong, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Hui Li

“…In this study, we explored the effects and potential mechanisms of Qizhu-Ruogan-Granules (QZRG), a formulation from the Affiliated Hospital of the Chengdu University of TCM, on carbon tetrachloride (CCl4)-induced liver fibrosis in mice.MethodsA total of 40 male C57BL/6J mice were randomly divided into five groups (n = 8 per group), with liver fibrosis induced by injecting 10% CCl4 for 15 weeks. …”
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Evaluation of three-dose fosfomycin tromethamine in the treatment of patients with urinary tract infections: an uncontrolled, open-label, multicentre study by Shan Chen, Yong Yang, Bo Yang, Ming Chen, Kai Zhang, Yi Wang, Lu-Dong Qiao, Bo Zheng, Hong-Feng Guo, Yuan-Jie Niu, Ben-Kang Shi, Wei-Min Yang, Xiao-Kun Zhao, Xiao-Feng Gao

“…Clinical symptoms, physical signs, urinalysis, liver and kidney function, patient records and evaluation of adverse events (AEs) and serious AEs up to day 15 were evaluated for analysis of safety.Results 361 patients were included in the full analysis set, 356 in the safety analysis set and 335 in the per-protocol set (PPS). In the PPS, the clinical efficacy rates at day 15 for acute uncomplicated cystitis, recurrent lower urinary tract infection and complicated lower urinary tract infection were 94.71% (179/189), 77.22% (61/79) and 62.69% (42/67), respectively. …”
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Exploring clinicians’ perspectives on the ‘Obstetric Anal Sphincter Injury Care Bundle’ national quality improvement programme: a qualitative study by Ipek Gurol-Urganci, Nick Sevdalis, Edward Morris, Posy Bidwell, Ranee Thakar, James M Harris, Louise Silverton, Alexandra Hellyer, Robert Freeman, Vivienne Novis

“…Focus groups took place approximately 3 months following initial implementation of the care bundle in each unit.Participants A total of 101 clinicians participated, with an average of six per focus group. Participants volunteered to take part and compromised of 37 obstetricians and 64 midwives (including eight students). …”
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Feeding Behavior, Water Intake, and Physiological Parameters of Feedlot Lambs Fed with Diets Containing Babassu Oil Associated with Sunflower Oil Blend by Laryssa V. da Silva, Gleice Kelle S. M. Vilela, Karlyene S. da Rocha, Hactus S. Cavalcanti, Glayciane C. Gois, Francisco Naysson de S. Santos, Fleming S. Campos, Michelle de O. M. Parente, Anderson de M. Zanine, Daniele de J. Ferreira, Tobyas M. de A. Mariz, Danielle de O. Maia, Henrique N. Parente

“…In relation to SO levels, water intake via drinking fountain (P=0.002), total water intake (P=0.002), and total water intake per kg of DM ingested (P=0.001) linearly increased with the levels increase in the composition of the diets. …”
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Who Are Suitable Patients for Omitting Breast Surgery as an Exceptional Responder in Selected Molecular Subtypes of Breast Cancer After Neoadjuvant Systemic Treatment? by Ebru Sen, Mehmet Ali Nazlı, Göktürk Maralcan, Bekir Sıtkı Said Ulusoy, Mahmut Kaan Demircioğlu, Tuce Söylemez Akkurt, Mehmet Sökücü, Gökmen Umut Erdem, Mustafa Yıldırım

“…To assess neoadjuvant treatment response, a standardised biopsy protocol was used, consisting of 10 samples from the marked tumour area per patient by 12 G core needle. Then, all patients underwent surgery. …”
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Teaching communication skills to OTL-HNS residents: multisource feedback and simulated scenarios by Pier-Luc Beaudoin, Mathilde Labbé, Amanda Fanous, Meredith Young, Jamie Rappaport, Yoon Soo Park, John Manoukian, Lily H. P. Nguyen

“…Results from the random-intercept regression indicated that, on average, a learner’s mean rating at baseline was 3.6/5 and increased significantly by 0.25 points per year (p < 0.05) as assessed by OTL-HNS staff members and peers. …”
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Frequency, demographics, diagnoses and consultation patterns associated with low-acuity attendances in German emergency departments: a retrospective routine healthcare data analysi... by Patrik Dröge, Anna Slagman, Felix Greiner, Martin Möckel, Liane Schenk, Anna Schneider, Thomas Keil, Stephanie Roll, Rainer Röhrig, Felix Walcher, Reinhard Busse, Johannes Drepper, David Legg, Ryan King, Thomas Reinhold, Thomas Ruhnke, Antje Fischer-Rosinský, Yves-Noel Wu, Natalie Baier, Maike Below, Cornelia Henschke, Björn Kreye, Christian Lüpkes, Burgi Riens, Marie-Luise Rosenbusch, Felix Stäps, Kristin Schmieder, Daniel Schreiber, Dominik von Stillfried, Grit Zimmermann

“…The highest proportion of low-acuity presentations was observed during the weekend (average of 18.6% per day), compared with an average of 12.5% on weekdays. …”
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PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release by Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang

“…Methods: In this study, the molecular mechanism of NET release and the potential beneficial effects of PPARα agonists on the HCC microenvironment were explored through proteomics, metabolomics, tissue microarray, immunofluorescence, flow cytometry, western blot, and dual-luciferase reporter gene assays (n = 6 per group). Results: Our study demonstrated a notable inhibition of PPARα signaling in HCC. …”
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