The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193–1.771) and SBM within 24 h (RR 1.790, 95% CI 1.491–2.150) in patients with chronic idiopathic constipation (CIC). …”
Get full text

Application of multi-indexing approach within a GIS framework to investigate the quality and contamination of ground water in Barisal sadar, Bangladesh by Md. Numan Hossain, M. Farhad Howladar, Sohag Ahammed, Md Rezwanul Haque, Majedul Islam Khan, Muyeed Hasan, Tayabur Rashid Chowdhury, Alamgir Hosain

“…The significant positive correlations among EC, TDS, TH, turbidity, salinity, NaCl, chloride, and calcium ions as per correlogram, principal component analysis (PCA) biplot, and heat map clustering, indicating similar sources of origin. …”
Get full text

Impact of primary care benefits on healthcare utilisation and estimated out-of-pocket expenses in urban, rural and remote settings in the Philippines by Antonio L Dans, Arianna Maever L Amit, Leonila F Dans, Gillian Sandigan, Regine Ynez H De Mesa, Mia P Rey, Josephine T Sanchez, Cara Lois T Galingana, Nannette Bernal-Sundiang, Maria Rhodora N Aquino, Johanna Faye E Lopez, Janelle Micaela S Panganiban, Romelei Camiling-Alfonso, Jose Rafael A Marfori, Ramon Pedro Paterno, Carol Stephanie Chua Tan-Lim, Noleen Marie Fabian, Chad Lester Lastrilla, Miguel Callo

“…In this study, two key outcomes were monitored: (1) monthly healthcare utilisation measured by the total number of outpatient consultations per site and (2) change in OOP expenses from baseline to endline within a 1 year study period.Results All sites had a positive trend in monthly outpatient consultations in healthcare utilisation over 1 year. …”
Get full text

Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells by Zhiwei Yuan, Taiyan Yu, Xu Wang, Kelin Meng, Tianlai Wang, Boyu Wang, Yu Xi, Congjian Wang, Chenxi Zeng, Shaojie Hu, Yitao Tian, Hui Xiong, Qi Wang, Wenbin Zou, Xue Wang, Yi Gao, Xiangning Fu, Lequn Li

“…The administration of CQ increased the sensitivity of ASCT2-deficient tumors to anti-PD-L1 therapy. Glutamine deprivation per se leads to resistance to immunotherapy, whereas V9302 treatment results in increased immunotherapy efficacy through impaired lysosomal activity, which is independent of glutamine deprivation.…”
Get full text

Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience by Niall Leahy, Cillian O’Brien, Sara Essa Alsubai, Eileen Coen, Darragh Murphy, Faisal Sharif

“…The difference in the mean number of HF hospitalisations per patient pre- and post-device insertion was 0.70 (<i>p</i> < 0.0001). …”
Get full text

Infectious outcomes of a standardized subcutaneous immunoglobulin dose reduction strategy in primary immune deficiencies amid global shortage by Pedro Moral Moral, Pedro Moral Moral, Marta Dafne Cabanero-Navalon, Marta Dafne Cabanero-Navalon, Paula Teresa López-León, Paula Teresa López-León, Héctor Balastegui-Martín, Héctor Balastegui-Martín, Sandra Martínez Mercader, Sandra Martínez Mercader, Amparo Mir, Victor Garcia-Bustos, Victor Garcia-Bustos, Victor Garcia-Bustos

“…The dose reduction saved an average of 5,550 euros per patient annually, totaling 172,050 euros annually for our cohort.DiscussionOptimizing SCIg doses in selected well-controlled humoral PIDs is feasible without increasing infection rates, conserving this plasma-derived product during shortages. …”
Get full text

Lenvatinib versus sorafenib as second-line therapy following progression on atezolizumab–bevacizumab in patients with unresectable hepatocellular carcinoma: a multicenter retrospec... by Jaekyung Cheon, Shigeo Shimose, Hyung-Don Kim, Takashi Niizeki, Min-Hee Ryu, Tomotake Shirono, Baek-Yeol Ryoo, Hideki Iwamoto, Changhoon Yoo

“…After PSM, in a cohort of 50 patients (25 per each group), LEN maintained its PFS advantage over SOR (median 4.8 vs. 3.3 months, p = 0.046), while the median OS was longer with LEN but not statistically different (median 11.4 vs. 7.9 months, p = 0.197). …”
Get full text

Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China by Xiaowen Wang, Junhui Wu, Yao Wu, Mengying Wang, Zijing Wang, Tao Wu, Dafang Chen, Xun Tang, Xueying Qin, Yiqun Wu, Yonghua Hu

“…Mediation analysis was then used to test whether KCNQ1 participated in T2DM pathogenesis via lipid-mediated pathways. Results. Per allele-C of rs2237895 was associated with 17% (11-23%, P<0.001) increased T2DM risk. …”
Get full text

Overcoming barriers to engagement and adherence to a home-based physical activity intervention for patients with heart failure: a qualitative focus group study by Guy A MacGowan, Sarah Charman, Djordje G Jakovljevic, Nduka C Okwose, Nicola O'Brien, Sophie Cassidy, David Brodie, Kristian Bailey, Leah Avery

“…Data were analysed using thematic analysis.Participants A purposive sample of 16 patients, 82% male, aged 68±7 years, with heart failure duration of 10±9 years were recruited.Intervention A 12-week behavioural intervention targeting physical activity was delivered once per week by telephone.Results Ten main themes were generated that provided a comprehensive overview of the active ingredients of the intervention in terms of engagement and adherence. …”
Get full text

Posttraumatic Stress Disorder Is Associated With Endothelial Dysfunction in Women With HIV by Nishant Vatsa, MD, Alireza Rahbar, MD, Tanveer Kauser, MPH, Ariel Kirksey, BS, Daniel A. Gold, MD, Vardhmaan Jain, MD, Matthew E. Gold, MD, Heqiong Wang, MD, MPH, Christina Mehta, PhD, MSPH, Caitlin A. Moran, MD, Alicia K. Smith, PhD, Kimbi Hagen, EdD, Med, Ighovwerha Ofotokun, MD, MSc, Cecile D. Lahiri, MD, MS, Laurence Sperling, MD, Viola Vaccarino, MD, PhD, Puja K. Mehta, MD, Arshed A. Quyyumi, MD, Gretchen N. Neigh, PhD, Vasiliki Michopoulos, PhD

“…In adjusted models, the HIV-PTSD (severity and status) interaction effect on FMD was significant (P = 0.01). Both PTSD severity (β per 10-point increase: −0.72% [95% CI: −1.22 to −0.21], P = 0.01) and PTSD status (β: −2.51% [95% CI: −4.21 to −0.77], P = 0.01) were independently associated with lower FMD in WWH but not in those without HIV. …”
Get full text

Study protocol of a population-based cohort investigating Physical Activity, Sedentarism, lifestyles and Obesity in Spanish youth: the PASOS study by Susana Aznar, Camille Lassale, Santiago Felipe Gómez, Clara Homs, Julia Wärnberg, Maria Medrano, Marcela Gonzalez-Gross, Narcis Gusi, Elena Marín Cascales, Miguel González-Valeiro, Lluis Serra-Majem, Nicolás Terrados, Josep A Tur, Marta Segú, Juan Carlos Benavente-Marín, Idoia Labayen, Augusto García Zapico, Jesús Sánchez-Gómez, Fabio Jiménez-Zazo, Pedro Emilio Alcaraz, Marta Sevilla-Sanchez, Estefania Herrera-Ramos, Susana Pulgar, Maria del Mar Bibiloni, Olga Sancho, Helmut Schröder

“…This observational, nationally representative, multicentre study aims to determine the PA levels, sedentary behaviours and prevalence of physical inactivity (defined as &lt;60 min of moderate to vigorous PA per day) in a representative sample of Spanish children and adolescents. …”
Get full text

The incidence of radiologically verified community-acquired pneumonia requiring hospitalisation in adults living in southern Sweden, 2016-2018: a population-based study by Elisabeth Rünow, Frida Valeur, Gustav Torisson, Karin Hansen, Christian Theilacker, Kristian Riesbeck, Jonas Ahl

“…The crude incidence rate of CAP requiring hospitalization was 259 (95% CI: 246–272) and age-standardized rate was 294 (95% CI: 280–309) per 100,000 person-years. Among those aged 80 years and older, hospitalization rate was 17 times higher vs those aged 18–64 years, yielding an IRR 17.4 (95% CI: 15.4–19.7). …”
Get full text

Causal associations of ambient particulate matter 10 and Alzheimer’s disease: result from a two-sample multivariable Mendelian randomization study by Zehan Huang, Guodong He, Shuo Sun, Yingqing Feng, Yuqing Huang

“…In the univariate MR, pooled meta-analysis of genetically predicted PM10 was associated with a 99% increased risk of AD (95% CI: 1.25, 3.15, p = 0.004) per 1 standard deviation (SD) increment of PM10 by IVW, and in the multivariable MR with pooled meta-analysis, we found that each SD increase in PM10 was associated with a 127% increase in the risk of AD (95% CI: 1.33, 3.86, p = 0.002) after accounting for education levels. …”
Get full text

Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Cana... by Lawrence C McCandless, Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Sander Greenland, Micah Piske, Trevor Thomson, Emanuel Krebs, Natt Hongdilokkul, Julie Bruneau, M Ehsan Karim, Judith I Tsui

“…We will determine the effectiveness of buprenorphine/naloxone vs methadone using intention-to-treat and per-protocol analyses—the former emulating flexible-dose trials and the latter focusing on the comparison of the two medication regimens offered at the optimal dose. …”
Get full text

INTERFAITH MARRIAGE CONTROVERSIES IN SEMARANG: AN ANALYSIS OF QUR'ANIC LEGAL EXEGESIS by Abdul Basid, Lilik Nur Kholidah, Muhammad Fahmi Hidayatullah, Eka Kurnia Firmansyah, Ahmad Iwan Zunaih, Reza Ahmad Zahid

“…A considerable part of society shows contempt, as per the religious views such marriages can endanger the family’s spirituality. …”
Get full text

Development of a model for measuring sagittal plane parameters in 10–18-year old adolescents with idiopathic scoliosis based on RTMpose deep learning technology by Zhijie Kang, Guopeng Shi, Yong Zhu, Feng Li, Xiaohe Li, Haiyan Wang

“…The model took an average of 9.27 s to automatically measure the 15 anatomical parameters per X-ray image. Conclusion The deep learning model based on RTMpose can effectively enhance clinical efficiency by automatically measuring the sagittal plane parameters of the spine in X-rays of patients with AIS. …”
Get full text

Assessing water dependencies and risks in Dutch industries: Distribution, consumption and future challenges by C.J. Teo, J. Poinapen, J.A.M.H. Hofman, T. Wintgens

“…It advocated a more sophisticated approach that moves beyond mere water usage per unit of output to encompass the production complexities that significantly affect water dependency in particular industries. …”
Get full text

Sustainability index analysis of microalgae cultivated in biorefinery palm oil mill effluent by A. Santoso, T. Handayani, D. Pinardi, K. Kusrestuwardani, N. Widyastuti, I. Djarot, J. Haryanti, A. Sitomurni, H. Apriyanto

“…Some leverage attributes that require more attention in order to improve sustainability are management experience and skills (in environment dimension), involvement of family member (in the social dimension), the productivity level (in economic dimension), and management of experience and skill (technological dimention).CONCLUSION: Based on the prospective analysis, it is known that there are 4 key factors or dominant factors that are very influential in the microalgae supply system, namely production, productivity, land conversion, consumption per capita and population. It is still necessary to do further research for the utilization of microalgae biomass into value-added products with an optimal, technically, economically, environmentally and socially sustainable system. …”
Get full text

Efficacy and safety of non-invasive low-frequency tibial nerve stimulator in overactive bladder by Zhipeng Zhang, Mengzhu Liu, Yangyun Wang, Peng Wu, Yiping Zhu, Bangmin Han, Zhihui Xu, Xudong Li, Chaoliang Shi, Jing Zhang, Deyi Luo, Guowei Shi, Yaoguang Zhang

“…The absolute and percent changes of average UUI episodes per day from baseline at week 8 in the TNS-01 group were significantly lower from those in the sham group (0.11 ± 1.33 vs 0.68 ± 2.14, p = 0.01; − 27.82% ± 167.33% vs 87.18% ± 25.20%, p = 0.04). …”
Get full text

Progress and insights from worldwide deep coalbed methane exploration and development by Jiaqi ZHANG, Zengqin LIU, Baojian SHEN, Shihu ZHAO, Xinjun CHEN, Jincheng YE

“…Multiple horizontal wells in the Daning-Jixian and Daniudi gas fields produce more than 100 000 m3 of gas per day. Deep CBM exploration in the Sichuan Basin has made positive progress, and the Junggar Basin shows potential for deep CBM exploration. …”
Get full text