Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients by Justin Y. Tang, Nitin Ohri, Rafi Kabarriti, Santiago Aparo, Jennifer Chuy, Sanjay Goel, Jonathan M. Schwartz, Milan Kinkhabwala, Andreas Kaubisch, Chandan Guha

“…Multivariable Cox proportional hazards modeling demonstrated that both baseline MELD-Na (HR=1.07 per unit increase, 95% CI 1.03 to 1.11, p<0.001) and changes in MELD-Na exceeding 40% (HR=3.69, 95% CI 2.39 to 5.69, p<0.001) were independently associated with increased mortality risk. …”
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Gastrointestinal symptoms and bowel habits in 53 046 healthy Danish blood donors: a nationwide cross-sectional study by Christian Erikstrup, Ole Birger Pedersen, Henrik Hjalgrim, Erik Sørensen, Jens Frederik Dahlerup, Klaus Rostgaard, Mikkel Steen Petersen, Sisse Rye Ostrowski, Susan Mikkelsen, Khoa Manh Dinh, Thorsten Brodersen, Janna Nissen, Anne Karmisholt Grosen, Jens Kjærgaard Boldsen, Simon Mark Dahl Baunwall, Mie Topholm Bruun, Bitten Aagaard, Christina Mikkelsen, Christian Lodberg Hvas

“…Half of the participants (50%) had a regular defaecation pattern (defined as generally the same stool consistency and stool frequency) consisting of Bristol Stool Form Scale 4 stools 1–3 times per day. Symptom phenotypes and their prevalence among 51 820 near-complete case participants were as follows: (1) no gastrointestinal symptoms (32%); (2) bloating and/or rumbling only (21%); (3) acid regurgitation and/or heartburn only (4%); (4) any other one or two symptoms (14%); (5) any three or four symptoms (18%); (6) any five or six symptoms (7%); (7) at least seven symptoms (3%). …”
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Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…The findings will be published in a peer-reviewed journal, including positive, negative and inconclusive results.Trial registration number NCT04730037.Protocol version This paper was written per the study protocol V.4.0, dated 29 January 2021.…”
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Reproductive Performance in a Selected Sample of Dairy Farms in Una-Sana Canton, Bosnia and Herzegovina by Adis Softic, Adam Dunstan Martin, Eystein Skjerve, Nihad Fejzic, Teufik Goletic, Aida Kustura, Erik Georg Granquist

“…The mean number of services per pregnancy was 2.61 (range 1–12). The median calving-to-first-insemination interval was 62.5 days (5th–95th percentile range 16–408). …”
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Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) by Tingyi Liang, Shaochi Zhang, Xiang Zhang, Xiaohan Wang, Xunda Ji, Peiquan Zhao

“…An average of 1.5 additional laser photocoagulation sessions was performed per patient. After a median follow-up of 23 months (range, 11–33 months), all eyes demonstrated retinal cyst resolution and no active disease. …”
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When is “convenient time” for residents?: a trial of Resident Study Log as asynchronous learning tool for residents by Tadayuki Hashimoto, Shoko Ariyoshi, Taira Ariyoshi, Ryosuke Horitani, Mohammad Adrian Hasdianda, Kanapa Kornsawad, Shunsuke Kosugi, Makoto Kikukawa, Tomio Suzuki

“…The outcome measured included the frequency and timing of posts as well as residents’ satisfaction and perceived burden, which were assessed through anonymous surveys.Results A total of 31 residents participated during the study period, posting 599 entries on the Resident Study Log, averaging one post per resident every two days. Participants reported an average satisfaction score of 5.3 out of 6.0 (6-point Likert scale, where 1 indicated ‘not satisfied at all’ and 6 indicated ‘very satisfied’), while the perceived burden averaged 4.0 out of 6.0 (6-point Likert scale, where 1 indicated ‘not burdensome at all’ and 6 indicated ‘very burdensome’). …”
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Adaptation variation of easiness on environmental, social, and governance components in the selected sustainability developments by F.R. Sutikno, N.A. Sasongko, I.N. Djarot, H.S. Dillon

“…The novelty of this study combined the use of unified comparison components, a wider range of scaling measurements, and specific environmental social, and governance components per-industry type.…”
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A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane by Francisco Maduell, Victor Joaquín Escudero-Saiz, Elena Cuadrado-Payán, Maria Rodriguez-Garcia, Miquel Gómez, Lida María Rodas, Néstor Fontseré, Maria del Carmen Salgado, Gregori Casals, Nayra Rico, José Jesús Broseta

“…There were significant differences in the albumin dialysate losses, with the highest value obtained with the Toraylight NV in auto-substitution HDF, with more than 50% of patients surpassing 5 g per session. The Toraylight NV dialyzer has great potential for efficacy but should be used at the optimal convective volume (Qi not exceeding 75 mL/min or FF not exceeding 25%) to avoid excessive albumin loss.…”
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Investigating the implementation of a Trial of Labour After Caesarean (TOLAC) delivery bundle with respect to decreasing caesarean delivery rates: a multisite quality improvement i... by Eliane M Shore, Elizabeth Miazga, Cheyanne Reed, Alisha Olsthoorn, Isabella Fan, Eliya Zhao, Jodi Shapiro, Amanda Cipolla, Modupe Tunde-Byass

“…Objectives To study the effect of implementing a Trial of Labour After Caesarean (TOLAC) delivery bundle with respect to decreasing caesarean delivery rates across five hospitals.Design Prospective quality improvement study.Setting Five Canadian hospital sites participated, two academic centres and three community hospitals, with annual delivery rates ranging from 2500 to 7500 per site.Participants All obstetrical patients with a singleton gestation in cephalic presentation and only one previous caesarean delivery were included.Interventions A TOLAC bundle was introduced at each hospital site, consisting of three main interventions: (1) education for healthcare providers, (2) a TOLAC discussion sheet and (3) patient educational tools.Primary and secondary outcome measures The primary outcome was the caesarean delivery rate in eligible patients. …”
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Estimation and mapping of the contribution of nitric acid to atmospheric corrosion of zinc by J. Castillo-Miranda, F. Rodríguez-Gómez, J. Genescá-Llongueras, L. Ruiz-Suárez, J. García-Reynoso

“…FINDINGS: The results showed that spatial and temporal estimation of corrosion rates in grams per square meter of zinc was made for 2015-2019, using data modeling in a geographic information system. …”
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Comparison of Brain Activation Between Different Modes of Motor Acquisition: A Functional Near‐Infrared Study by Meng‐Hsuan Tsou, Pei‐Yun Chen, Yi‐Ting Hung, Yong‐Wei Lim, Shiuan‐Ling Huang, Yan‐Ci Liu

“…Participants performed a functional reaching and grasping task under ME, MI, AO, and MVF mode with their right arms at a frequency of 0.5 Hz for 1 min per task. Each task was performed three times in a random order. …”
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Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis by Vitor Engracia Valenti, André dos Santos Chagas, Peter Chedraui, Ingrid Soares de Souza, Andrey Alves Porto, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Júnior, Juliana Zangirolami-Raimundo, David M. Garner, Rodrigo Daminello Raimundo

“…Exercise intervention ranged between two to four days per week. Compared to the control group, in the group submitted to aerobic exercise + resistance training, no significant change was noted for HbA1c (subtotal = mean difference − 0.35 [95% CI: −0.85, 0.15], p = .17, and heterogeneity = 0%) (GRADE: very low), nevertheless, HOMA-IR index was significantly improved (subtotal = mean difference −0.52 [95% CI: −0.99, −0.05], p = .03, and heterogeneity = 0%) (GRADE: very low).Conclusion Despite the very low certainty found in the quality of evidences, our analysis showed that aerobic exercise along with strength exercise seems to improve some metabolic diabetes markers in postmenopausal women with T2DM. …”
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Effectiveness of Voytik-Harbin Protocol in Fabrication of Ram’s Testicular-Derived Hydrogel and Its Impact on Mouse In Vitro Spermatogenesis by Leila Rashki Ghaleno, Tohid Rezaei Topraggaleh, Leila Montazeri, Abdolhossein Shahverdi, Mojtaba Rezazadeh Valojerdi

“…The VH protocol was involved 10 mg of pepsin per 100 mg of ECM in 0.5 M ofacetic acid. Subsequently, mouse testicular cells were cultivated on collagen hydrogel as the control and the moreeffective testicular-derived hydrogel (TDH) to evaluate the early stages of in vitro spermatogenesis.Results: While the Freytes protocol produced a homogeneous pre-gel solution with both HCl concentrations; elevatingthe pH to 7.4 loosened the hydrogel and made gelation problematic. …”
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Effects of compost from food waste on growth of lettuce ( Lactuca sativa Var. Crispa L.) by Aunkamol Kumngen, Jutarut Iewkittayakorn, Usmana Meehae, Sudarat Suwannarat, Sujunya Anuchan, Wilaiwan Chotigeat, Pattamavadee Kunwanlee, Noodchanath Kongchouy, Siwapong Leunram, Seppo Karrila

“…Purpose Thailand generates approximately 18 million tons of urban food waste per year, which is disposed of with municipal waste and largely goes to landfills. …”
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Identification of positive childhood experiences with the potential to mitigate childhood unhealthy weight status in children within the context of adverse childhood experiences: a... by Brooklyn M. Mellar, Maryam Ghasemi, Pauline Gulliver, Barry Milne, Fiona Langridge, Tracey McIntosh, Christa Fouche, Boyd Swinburn, Ladan Hashemi

“…The analytic sample was restricted to those who provided obesity data at age 8 and one child per mother, resulting in a sample of 4,895 children. …”
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Implementing sustainable practices to combat root knot nematode infestation in tomato farming from Meghalaya by H. Jeevan, Raghubir Kumar Patidar, Veronica Kadam, Pranab Dutta, Euphema Nongbri, M. N. Rudra Gouda, Santosh Naik, N. S Nysanth

“…T7 also minimized the final soil nematode population to 106.33 ± 1.01 per 100 g, closely followed by T8 (94.67 ± 0.89). …”
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Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

“…Patients with AF aged ≥18 years with moderate or severe MS not planned for valvular intervention in the coming 12 months will be randomised in a 1:1 ratio to receive dabigatran 110 mg or 150 mg two times per day or warfarin with international normalised ratio 2–3 in an open-label design. …”
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COVID-19 morbidity in Afghanistan: a nationwide, population-based seroepidemiological study by Siyu Chen, Fatima Arifi, Mohammad Nadir Sahak, Sayed Ataullah Saeedzai, Lisa J White, Amal Barakat, Eman Abdelkreem Aly, Margo van Gurp, Giti Azim, Bahara Rasoly, Soraya Safi, Jennifer A Flegg, Nasar Ahmed, Mohmmad Jamaluddin Ahadi, Niaz M Achakzai, Alaa AbouZeid

“…For each region, 31–44 enumeration areas (EAs) were randomly selected, and a total of 360 clusters and 16 households per EA were selected using random sampling. To adjust the seroprevalence for test sensitivity and specificity, and seroreversion, Bernoulli’s model methodology was used to infer the population exposure in Afghanistan.Outcome measures The main outcome was to determine the prevalence of current or past COVID-19 infection.Results The survey revealed that, to July 2020, around 10 million people in Afghanistan (31.5% of the population) had either current or previous COVID-19 infection. …”
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Practice, Experiences, and Facilitators of Simulation-Based Training During One Year of Implementation in 30 Hospitals in Tanzania by Benjamin A. Kamala MD, PhD, Robert Moshiro MD, PhD, Florence S. Kalabamu MD, MMED, Torgeirsen Kjetil BScN, MSc, Godfrey Guga BSc, Beatrice Githiri BSc, Justine Samson BSc, Philimon Chavala BScN, Grace Qorro MD, MPH, Damas Kayera MD, MPH, Ivony Kamala BScN, MPH, Catherine Massay BScN, MSc, Paschal Mdoe MSc, PhD, Vickfarajaeli Daudi MD, MMED, Esto Mduma MSc, PhD, Shally Mwashemele MD, MPH, Felix Bundala MD, MSc, Hege Ersdal MD, PhD, Sara Rivenes Lafontan BScN, MPH, PhD

“…Results A large and sustained number of in-situ NNL skill-training sessions ( n  = 35,101) and facilitator-led team simulations ( n  = 266) were conducted during the first year. Clinical burden per HCW did not affect the frequency of NNL skills training at the health facility level ( r  = −0.16, p  = .40) nor facilitator-led team simulations. …”
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Market participation and profitability of small scale garri processing in Edo, Ogun and Oyo States, Nigeria by Jelili Olaide Saka, Veronica Adeoti Obatolu, Bosede Olukemi Lawal, Ayodeji Babatunde Idowu, Chukwudi Peter Amadi, Johnson Adedayo Adetumbi, Taofik Oyedele Dauda

“…Garrification rates were higher in Ogun (26.54%, 20.25%) and Oyo (24.09%, 15.57%) than in Edo state (23.44%, 14.15%) in the dry and wet seasons respectively, with the latter having a shorter processing period. Cost per kilogram of garri produced was lowest in Edo state during the dry season but highest during the rainy season. …”
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