Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa [version 2; peer review: 1 approved, 2 approved with reservations] by Jane E Hirst, Ana Bonell, Abdul Sesay, Leonidas G. Ioannou, Bubacarr Bah, Kris A. Murray, Andy Haines, Sophie E. Moore, David Jeffries, Neil S Maxwell, Ana Vicero-Cabrera, Apolline Saucy, Cally Tan, Emmanuel Okoh, Dorothy Watters, Bakary Sonko, Williams Oluwatosin Adefila, Yahaya Idris, Mam Leigh-Nabou, Jarra Manneh, Andreas Flouris, Sainabou Bojang, Amanda N Sferruzzi-Perri, Andrew Prentice

“…The key objectives of the study are to 1) map exposure to heat stress in the cohort and understand what environmental, social and community factors increase the risk of extreme heat exposure; 2) assess the impact of heat stress on maternal health, e.g. heat strain, subjective psychological well-being, sleep and activity level; 3) evaluate how heat stress impacts placenta structure and function; 4) determine how chronic heat exposure impacts birth outcomes; and 5) explore the epigenetic changes in the placenta and infant by heat stress exposure per trimester. Pregnant women will be recruited from two distinct regions in The Gambia to exploit the naturally occurring heat gradient across the country. …”
Get full text

Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…After 14 days, and for another 4 weeks, MET (100 mg/kg per day) was added to half of each group’s drinking source, thus C (water), F (fructose), M (MET) and FM (fructose + MET). …”
Get full text

Image-based anomaly detection in low-light industrial environments with feature enhancement by Dinh-Cuong Hoang, Phan Xuan Tan, Anh-Nhat Nguyen, Son-Anh Bui, Ta Huu Anh Duong, Tuan-Minh Huynh, Duc-Manh Nguyen, Viet-Anh Trinh, Quang-Huy Ha, Nguyen Dinh Bao Long, Duc-Thanh Tran, Xuan-Tung Dinh, Van-Hiep Duong, Tran Thi Thuy Trang

“…Additionally, the framework maintains a real-time inference speed of 60 frames per second (FPS), making it well-suited for deployment in industrial settings. …”
Get full text

Effect of daily alcohol consumption and age over 40 years on COVID-19 vaccination antibody titers in the Delta era among hospital workers in northern Okinawa, Japan: A retrospectiv... by Takuji Kishimoto, Daisuke Tasato, Yoshitaka Nagasawa, Akihiro Yamashiro, Hayashi Shokita

“…Results: The crude incidence rates per 1,000 person-days for Lower-25 % among women and men were 1.35 and 1.66, respectively. …”
Get full text

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis by Shixuan Liu, Ceryl Tan, Chloe Melo-Gavin, Miriam B Ginzberg, Ron Blutrich, Nish Patel, Michael Rape, Kevin G Mark, Ran Kafri

“…In contrast, oversized cells that undergo compensatory growth slowdown exhibit a superlinear increase in proteasome-mediated protein degradation, with accelerated protein turnover per unit mass, suggesting activation of the proteasomal degradation pathway. …”
Get full text

Cold temperature-related attributable risk for emergency circulatory hospitalizations, length of stay, and healthcare costs in Hong Kong by Eliza Lai-Yi Wong, Hong Qiu

“…Temperature-related healthcare costs were evaluated based on the estimated attributable number (AN) and charges per attendance or bed day. Results: Among 1276,632 EHAs and 7621,232 bed days of LOS, significant associations of cold temperatures with both EHA counts and LOS for total and cause-specific circulatory diseases were found. …”
Get full text

Intravascular Imaging-Guided Percutaneous Coronary Intervention in Patients With End-Stage Renal Disease on Maintenance Dialysis by Chia-Pin Lin, MD, Fu-Chih Hsiao, MD, Ying-Chang Tung, MD, Tzyy-Jer Hsu, MD, Shing-Hsien Chou, MD, Yu-Sheng Lin, MD, Shao-Wei Chen, MD, PhD, Pao-Hsien Chu, MD

“…After matching, the incidence of the primary outcome was comparable between the OCT and IVUS groups (42.1 [95% CI: 36.2-48.0] vs 47.6 [95% CI: 43.0-52.2] events per 100 person-years; HR: 0.88; 95% CI: 0.74-1.06). …”
Get full text

Tracking pygmy blue whale diving behaviour and validation of foraging areas defined from horizontal movement data by Michele Thums, Luciana C. Ferreira, Andrew Davenport, Micheline Jenner, Luciana Möller, Grace Russell, Robert D. McCauley, Curt Jenner

“…Foraging/feeding occurred every 1–10 days at a rate of 4 hours (median) per day (range 0.1 – 12) and occurred during migration, providing support for use of a mixed breeding strategy (income and capital) in this sub-species. …”
Get full text

Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts by Jiaoquan Chen, Xinyi Xie, Yingxue Liu, Fengyi Chen, Yeqing Gong, Bihua Liang, Yiling Wu, Shiqi He, Yueming Li, Huilan Zhu, Shaoyin Ma

“…In total, 40 lesions were treated across 1 to 9 PDT sessions, with an average of 5.2 ± 2.86 sessions per patient. Complete clearance was achieved in 3 patients (30 %), 4 patients (40 %) showed an excellent response (≥80 % improvement), while 2 patients had a partial response. …”
Get full text

Reimagining habitat suitability modeling for Pacific saury (Cololabis saira) in the Northwest Pacific Ocean through acoustic data analysis from fishing vessels by Minghua Xue, Jianfeng Tong, Wen Ma, Zhenhong Zhu, Weiqi Wang, Shuo Lyu, Xinjun Chen

“…Instead of traditional fishing effort or catch per unit effort (CPUE) based HSI models, this acoustic index-based model offered an innovative approach with immutable evidence for establishing the relationship between sea surface temperature (SST, °C), sea surface temperature gradient (SSTG, °C/°), sea surface height (SSH, m), and chlorophyll a concentration (Chl, mg/m3) with suitable habitats. …”
Get full text

A Real-Time Human Pose Measurement System for Human-In-The-Loop Dynamic Simulators by Nicola Giulietti, Davide Todesca, Marco Carnevale, Hermes Giberti

“…The YOLOv8x-pose model with four cameras achieves the highest accuracy, with a Mean-Per-Joint Position Error of 18.2 mm and an execution time of 15 ms, outperforming state-of-the-art methods. …”
Get full text

The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…TCSs discontinuation increased the risk of clinical relapse (0.70 cases per person-year), whereas continuous use was linked to a rise in nonserious adverse events (dilation, infections, upper respiratory tract infections, and skin disorders). …”
Get full text

Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Histological scoring used the post-examination masking method with 100 visual fields per group. Results There was no significant damages to the tubules, glomeruli, and interstitial of the kidneys, including congestion, after exposure to non-contact electric fields. …”
Get full text

A cost–benefit analysis of the production system with improved and climate-resilient sorghum varieties in southern Mali by Adama B. Coulibaly, Félix Badolo, Félix Badolo, Jummai O. Yila, Jummai O. Yila, Bourema Koné, Baloua Nebié, Baloua Nebié, Nadine Worou, Nadine Worou, Macdonald Bright Jumbo, Kimseyinga Savadogo

“…A final sample of 31 farmers’ on-farm trials under the fertiliser package of “100 kg complex cereal and 50 kg urea” per hectare was held as the agronomic package. The key findings showed that both varieties were profitable, with 79,661 CFA (123.56 USD) and 45,073 CFA (69.91 USD) average net incomes corresponding to 1.54 and 1.32 CBR, and 34 and 24 percents average gross profit margins, respectively, while growing the “local” varieties was not profitable, with an average loss of 12,113 CFA (18.79 USD) with 0.91 CBR and 10 percent average gross profit margin. …”
Get full text

Rabies vaccinations at the rural–urban divide: successes and barriers to dog rabies vaccination programs from a rural and urban campaign in Zambia by Ricky Chazya, Chilufya Aneta Susan Mulenga, Andrew D. Gibson, Frederic Lohr, Cassandra Boutelle, Sarah Bonaparte, Oline Sinywibulula, Gareth Thomas, Patricia Bwalya, George Dautu, Linous Munsimbwe, Geoffrey Muuka, Luke Gamble, Ryan M. Wallace, Michelle A. Waltenburg

“…Extrapolating this relationship nationally, there are an estimated 3.2 million dogs in Zambia (human-to-dog ratio 5.8:1) with 86% residing in rural communities at a very low density of less than 6 dogs per square kilometer.DiscussionAs most dogs were found to reside at very low densities, unique challenges to large-scale dog vaccination approaches may impact Zambia, due to high logistical costs associated with these settings. …”
Get full text

Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches by Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan

“…No skin irritation was found for the optimized transdermal patch as per the Draize score method. The shelf life of the optimized formulation was 30.41 months under accelerated conditions. …”
Get full text

RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

Get full text

Nécropoles multipolaires et élaboration d’un nouveau modèle socio-politique au premier âge du Fer : réflexions à partir des sites du Camp de l’Église Sud à Flaujac-Poujols (Lot) et... by Antoine Dumas

“…Although the specific ceramic shapes are important, it appears that the individual profiles are primarily determined by differences relating to decorative practice (i.e. overall quantity of decorative motifs per group, types, combinations, etc.). The chronological information may then be considered. …”
Get full text

Dacostaite, K(Mg₂Al)[Mg(H₂O)₆]₂(AsO₄)₂F₆  ⋅  2H₂O, a new fluoride–arsenate mi... by C. Biagioni, C. Biagioni, D. Mauro, D. Mauro, J. Sejkora, Z. Dolníček, A. Dini, R. Škoda

“…The empirical formula of dacostaite, based on (As <span class="inline-formula">+</span> P) <span class="inline-formula">=</span> 2 atoms per formula unit, is (K<span class="inline-formula">_0.56</span>Ca<span class="inline-formula">_0.04</span>Na<span class="inline-formula">_0.03□_0.37</span>)<span class="inline-formula">_Σ1.00</span> (Al<span class="inline-formula">_1.54</span>Mg<span class="inline-formula">_1.38</span>Cu<span class="inline-formula">_0.03</span>Zn<span class="inline-formula">_0.03</span>)<span class="inline-formula">_Σ2.98</span> [Mg(H<span class="inline-formula">₂</span>O)<span class="inline-formula">₆</span>]<span class="inline-formula">₂</span> [(As<span class="inline-formula">_0.99</span>P<span class="inline-formula">_0.01)</span>O<span class="inline-formula">₄</span>]<span class="inline-formula">₂</span> [F<span class="inline-formula">_4.46</span>(OH)<span class="inline-formula">_1.46</span>O<span class="inline-formula">_0.08</span>]<span class="inline-formula">_Σ6.00</span> <span class="inline-formula">⋅</span> 2H<span class="inline-formula">₂</span>O (<span class="inline-formula"><i>Z</i>=2</span>). …”
Get full text

New insights on fission of 235U induced by high energy neutrons from a new measurement at n_TOF by A. Manna, E. Pirovano, P. Console Camprini, L. Cosentino, M. Dietz, Q. Ducasse, P. Finocchiaro, C. Le Naour, D. Mancusi, C. Massimi, A. Mengoni, R. Nolte, D. Radeck, L. Tassan-Got, N. Terranova, G. Vannini, A. Ventura, O. Aberle, V. Alcayne, S. Amaducci, J. Andrzejewski, L. Audouin, V. Babiano-Suarez, M. Bacak, M. Barbagallo, S. Bennett, E. Berthoumieux, J. Billowes, D. Bosnar, A. Brown, M. Busso, M. Caamaño, L. Caballero-Ontanaya, F. Calviño, M. Calviani, D. Cano-Ott, A. Casanovas, D.M. Castelluccio, F. Cerutti, E. Chiaveri, N. Colonna, G. Cortés, M.A. Cortés-Giraldo, S. Cristallo, L.A. Damone, P.J. Davies, M. Diakaki, C. Domingo-Pardo, R. Dressler, E. Dupont, I. Durán, Z. Eleme, B. Fernández-Domínguez, A. Ferrari, V. Furman, K. Göbel, R. Garg, A. Gawlik-Ramięga, S. Gilardoni, I.F. Gonçalves, E. González-Romero, C. Guerrero, F. Gunsing, H. Harada, S. Heinitz, J. Heyse, D.G. Jenkins, A. Junghans, F. Käppeler, Y. Kadi, A. Kimura, I. Knapová, M. Kokkoris, Y. Kopatch, M. Krtička, D. Kurtulgil, I. Ladarescu, C. Lederer-Woods, H. Leeb, J. Lerendegui-Marco, S.J. Lonsdale, D. Macina, T. Martínez, A. Masi, P. Mastinu, M. Mastromarco, E.A. Maugeri, A. Mazzone, E. Mendoza, V. Michalopoulou, P.M. Milazzo, F. Mingrone, J. Moreno-Soto, A. Musumarra, A. Negret, F. Ogállar, A. Oprea, N. Patronis, A. Pavlik, J. Perkowski, C. Petrone, L. Piersanti, I. Porras, J. Praena, J.M. Quesada, D. Ramos-Doval, T. Rauscher, R. Reifarth, D. Rochman, C. Rubbia, M. Sabaté-Gilarte, A. Saxena, P. Schillebeeckx, D. Schumann, A. Sekhar, A.G. Smith, N.V. Sosnin, P. Sprung, A. Stamatopoulos, G. Tagliente, J.L. Tain, A. Tarifeño-Saldivia, Th. Thomas, P. Torres-Sánchez, A. Tsinganis, J. Ulrich, S. Urlass, S. Valenta, V. Variale, P. Vaz, D. Vescovi, V. Vlachoudis, R. Vlastou, A. Wallner, P.J. Woods, T. Wright, P. Žugec

Get full text