A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…The biological activity of trastuzumab was determined using the inhibition of proliferation (IOP) assay on the SKBR3, which was optimized based on the parameters of cell seeding density, drug dilution range, and incubation time, and it was further validated as per the compendial guidelines and found valid for the parameters of specificity, accuracy (% relative bias = 0.0067%), precision (repeatability: % GCV = 1.21%), linearity (R2 = 0.99), and range (50% to 200%). …”
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Lifting COVID-19-associated non-pharmaceutical interventions: potential impact on notifications of infectious diseases transmitted from person to person in 2022 in Bavaria, Germany by Judith Hausmann, Judith Hausmann, Judith Hausmann, Achim Dörre, Katharina Katz, Sarah van de Berg

“…By analysing surveillance data from the federal reporting system for notifiable infectious diseases, we aimed to assess the potential impact of lifting COVID-19 associated NPIs on notifications of selected infectious diseases in Bavaria, 2022.MethodsWe compared influenza, chickenpox, norovirus gastroenteritis, rotavirus gastroenteritis weekly case numbers in a pre-pandemic period (2016–2019) and 2022 using two time series analyses approaches: (i) a predictive model forecasting weekly case numbers for the pandemic years 2020–2022, based on 2016–2019 data, (ii) interrupted time series model, based on 2016–2022 data, including a term per pandemic period.ResultsIn 2022, incidence rates were higher compared to pre-pandemic period for influenza (IRR = 3.47, 95%CI: 1.49–7.94) and rotavirus gastroenteritis (IRR = 1.36, 95%CI: 0.95–1.93), though not significant for rotavirus gastroenteritis. …”
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LOGINIŲ ŽINOJIMO PAGRINDŲ ANALIZĖ G. FREGE’S FILOSOFIJOJE by Nijolė Aukštuolytė

“…Frege’s tyrinėjimai remiasi prielaida, kad loginė minties analizė galima tik per loginę kalbos analizę. Straipsnyje norima pabrėžti, kad autoriaus dėmesys kalbai - netiesioginis. …”
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Predictive Factors of Mortality in Chronic Obstructive Pulmonary Disease Subjects: A Monocenter Prospective Observational Study in Algeria by Nadia Fettal, Nadjet Siali, Mahammed Chaker, Abdelbassat Ketfi

“…A threshold of three exacerbations per year was established to identify frequent exacerbators. …”
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Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia by Angefa Ayele, Dube Jara, Alo Edin, Digafe Hailu, Mihiret Kifle, Yohannes Fekadu

“…The overall DKA recovery rate was 23.8 per 1000 person-hours (95 % CI: 22.21–27.07), and the median recovery time was 42 hr. …”
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Rate estimation and trend analysis of new HIV infections among the international migrant population in Chile from 2013 to 2022 by Rodrigo Puentes, María Alejandra Dünner, Natalia T. Santis-Alay, Mario E. Soto-Marchant, Cecilia Canales, Janepsy Díaz

“…International migrants showed an increase in incidence rates between 2013 and 2022 (adjusted rate from 22.6 [95 % CI: 18.3 – 27.0] to 115.6 [95 % CI: 110.5 – 120.7] new HIV infections per 100,000 population). Throughout the study period, the ratio of adjusted incidence rates between international migrants and Chileans increased from 1.0 [95 % CI: 0.9 – 1.2] to 7.6 [95 % CI: 7.2 – 8.0]. …”
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Enterprise energy supply system design management based on renewable energy sources by S. Drobyazko, M. Skrypnyk, N. Radionova, O. Hryhorevska, M. Matiukha

“…By consuming traditional energy sources using outdated technologies for energy supply of industrial facilities, Ukraine consumes 3-4 times more fuel per unit of Gross Domestic Product compared to developed countries. …”
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Eosinofilik Esofagitis by Yusri Dianne Jurnalis, Yorva Sayoeti, Widiasteti Widiasteti

“…Diperkirakan insiden tahunan 43 per 10.000 pada anak. Gejala klinis mirip dengan GERD yaitu muntah, regurgitasi, nausea, nyeri dada atau epigastrium, disfagia dan hematemesis. …”
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High-Intensity Focused Ultrasound (HIFU) Focal Therapy for Localized Prostate Cancer with MRI-US Fusion Platform by Chi-Hang Yee, Peter Ka-Fung Chiu, Jeremy Yuen-Chun Teoh, Chi-Fai Ng, Chi-Kwok Chan, See-Ming Hou

“…It was observed that energy used per volume was positively correlated with PSA density of the patient (r = 0.6364, p=0.014). …”
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Effects of prenatal exercise interventions on maternal body composition: A secondary analysis of the FitMum randomized controlled trial. by Caroline Borup Roland, Parisa Seyedhosseini, Signe de Place Knudsen, Anne Dsane Jessen, Ida Karoline Bach Jensen, Jane M Bendix, Gerrit van Hall, Stig Molsted, Saud Abdulaziz Alomairah, Ellen Løkkegaard, Bente Stallknecht, Tine D Clausen

“…We also explored associations between physical activity (PA) per se and body composition. This study presents secondary outcomes of the FitMum randomized controlled trial, which included healthy inactive pregnant women at gestational age ≤ 15+0 weeks. …”
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Real-world cost-effectiveness analysis of thymoglobulin versus no induction therapy in kidney transplant recipients at low risk of graft loss by Adrieli Barros Bessa, Marina Pontello Cristelli, Claudia Rosso Felipe, Renato Demarchi Foresto, Marcelo Cunio Machado Fonseca, Jose Medina Pestana, Helio Tedesco-Silva

“…Results: The cost-effectiveness analysis in the first year revealed that the r-ATG group was more cost-effective, with an ICER of US$ 399.96 per avoided AR episode, an effectiveness gain of 0.01 year in graft survival and a total incremental cost of US$ 147.50. …”
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A Personalised Optimising Level Adaptation (OLA) Difficulty Algorithm for Scenario Simulations in Professional VR Simulators by Marcin Wolański Robert, Karol Jędrasiak

“…Results: Testing with 30 participants per simulator revealed an average final score of approximately 75%, closely aligning with the target success rate of 70%. …”
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Evaluation of Spray Drift from an Electric Boom Sprayer: Impact of Boom Height and Nozzle Type by Xiaoyong Pan, Shuo Yang, Yuanyuan Gao, Zhichong Wang, Changyuan Zhai, Wei Qiu

“…The results showed that the total drift amount per unit area (TDA) for the LI CHENG nozzle showed minimal variation at boom heights of 0.4–0.6 m (Stage 1), 0.7–0.9 m (Stage 2), and 1.0–1.2 m (Stage 3). …”
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Study of Antibacterial Activity of Root Bark, Leaves, and Pericarp Extracts of Diploknema butyracea and Evaluation of Prospective Antioxidant Activity by Alisha Karki Chhetry, Subhila Dhakal, Lalita Chaudhary, Khimdhoj Karki, Ram Bahadur Khadka, Gautam Prasad Chaudhary, Tonking Bastola, Amrit Poudel, Pramod Aryal, Jitendra Pandey

“…Likewise, flavonoid content ranged from 40.63 ± 1.28 µg to 889.72 ± 3.40 μg quercetin equivalent/mg of dry extract weight and total carbohydrate content ranged from 11.92 ± 0.60 µg to 174.72 ± 0.60 µg glucose equivalent per/mg dry extract weight. Overall, our study showed that the root bark, pericarp, and leaves extract of D. butyracea evinced prominent antibacterial properties against various pathogenic bacterial strains.…”
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Accuracy-dependent dose-constraints and dose-based safety margins for organs-at-risk in radiotherapy by Joep C. Stroom, Sandra C. Vieira, Carlo Greco, Sebastiaan M.J.J.G. Nijsten

“…Results: Results varied per OAR, fractionation, and constraint-type. If our 2.5mm/3% MDDcrit and SDDcrit values approximated dose-constraint studies, on average the DSM would be 4.5 Gy (18%) and our dose constraints would increase with 1.2 Gy (5%). …”
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Assessment of genetic diversity of some Siberian and Far Eastern species of the genus Spiraea (Rosaceae) by newly developed multiplex panels of nuclear SSR loci by T. A. Poliakova, A. V. Shatokhina, G. N. Bondarenko, D. V. Politov

“…Analysis of parameters of genetic variability in Spiraea spp. showed similar values of allele number per locus and observed heterozygosity among populations and slightly greater estimates of expected hete rozygosity in the samples of S. f lexuosa (NA = 2.387; HO = 0.387 ± ± 0.052; HE = 0.540 ± 0.055) as compared to S. ussuriensis (NA = = 2.781; HO = 0.385 ± 0.079; HE = 0.453 ± 0.072) and S. chamaedryfolia (NA = 2.875; HO = 0.331 ± 0.071; HE = 0.505 ± 0.069). …”
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Prevalence of metabolic syndrome with different serum vitamin D levels in middle-aged and older adults by Ya Zhao, Danting Su, Lichun Huang, Mengjie He, Dan Han, Dong Zhao, Yan Zou, Ronghua Zhang

“…After adjusting for age, sex, physical activity level, smoking status, education level, annual per capita household income, and body mass index residuals, the highest tertile (Q3) of vitamin D (odds ratio [OR], 0.779; 95% confidence interval [CI], 0.702–0.865) and vitamin D3 (OR, 0.787; 95% CI, 0.709–0.875) concentrations had a lower risk of MetS than the lowest tertile (Q1). …”
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Diet quality, psychological factors and their associations with risk factors of cardiovascular disease: a cross-sectional pilot study by Anneli Peolsson, Sanna Nybacka, Mireille Ryden, Per Leanderson

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TAXATION OF AGRICULTURAL ACTIVITY IN POLAND: THE CURRENT STATE AND FUTURE PROSPECTS by Marian Podstawka, Łukasz Podstawka

“…The current taxes applicable to farms in Poland do not concern income per se – they are property taxes which include: agricultural tax on land, forestry tax and property tax. …”
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Benefit Analysis of Precursor Emission Reduction on PM2.5: Using CMAQ-RSM to Evaluate Control Strategies in Different Seasons by Chih-Rung Chen, Hsin-Chih Lai, Min-Chuan Hsiao, Hwong-wen Ma

“…The RSM model was used to calculate the decreased concentration of PM2.5 under the reduction of primary PM2.5, NOx, SOx, and NH3 emissions, and then to estimate the impact of emission reduction on PM2.5 concentration per ton of precursor. The primary PM2.5 emission reduction benefits ranged from 9.43–9.79 × 10−5 µg m−3 t−1, NOx from 8.12–8.84 × 10−6 µg m−3 t−1, SOx from 6.15–7.45 × 10−6 µg m−3 t−1 and NH3 from 1.78–1.83 × 10−5 µg m−3 t−1. …”
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