Safety evaluation of the food enzym endo‐1,4‐β‐xylanase from the genetically modified Bacillus subtilis strain AR‐153 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Giulio diPiazza, Yi Liu

“…Exposure was estimated to be up to 0.463 mg TOS/kg body weight per day in European populations. Given the QPS status of the production strain and the absence of concerns resulting from the food enzyme manufacturing process, toxicity tests were considered unnecessary by the Panel. …”
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High Dose Ilaprazole/Amoxicillin as First-Line Regimen for Helicobacter pylori Infection in Korea by WonGun Kwack, YunJeong Lim, ChiYeon Lim, David Y. Graham

“…The cure rate of H. pylori was 79.3% (23 of 29) (95% confidence interval: 61.6–90.2) in the intention-to-treat analysis and 82.1% (23 of 28) in the per-protocol analysis. Compliance rates were high (96.6%) and side effects were minimal and tolerable. …”
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Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration by Krzysztof Marycz, Katarzyna Mierzejewska, Agnieszka Śmieszek, Ewa Suszynska, Iwona Malicka, Magda Kucia, Mariusz Z. Ratajczak

“…Human volunteers had trained in long-distance running for one year, six times per week. FACS-based analyses and RT-PCR of murine and human VSELs and HSPCs from collected bone marrow and peripheral blood were performed. …”
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PhotoD with LSST: Stellar Photometric Distances Out to the Edge of the Galaxy by Lovro Palaversa, Željko Ivezić, Neven Caplar, Karlo Mrakovčić, Bob Abel, Oleksandra Razim, Filip Matković, Connor Yablonski, Toni Šarić, Tomislav Jurkić, Sandro Campos, Melissa DeLucchi, Derek Jones, Konstantin Malanchev, Alex I. Malz, Sean McGuire, Mario Jurić

“…The computation speed is about 10 ms per star on a single core for both optimized grid search and Markov Chain Monte Carlo methods; we show in a companion paper by K. …”
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ECONOMICS OF EDUCATION: THE EXAMPLE OF THE BALKAN COUNTRIES by Ognjen Erić, Slaviša Kovačević, Jelena Bjelić, Dejan Molnar

“…The dependent variable is Gross National Income per capita (GNIpc), and the independent variables in the first model are years of education, macroeconomic stability, and ability to accept information technologies. …”
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Cancer phylogenetic tree inference at scale from 1000s of single cell genomes by Salehi, Sohrab, Dorri, Fatemeh, Chern, Kevin, Kabeer, Farhia, Rusk, Nicole, Funnell, Tyler, Williams, Marc J., Lai, Daniel, Andronescu, Mirela, Campbell, Kieran R., McPherson, Andrew, Aparicio, Samuel, Roth, Andrew, Shah, Sohrab P., Bouchard-Côté, Alexandre

“…Moreover, we introduce a novel point mutation calling method that incorporates the CN data and the underlying phylogenetic tree to overcome the low per-cell coverage of scWGS. We demonstrate our method on three single cell datasets, including a novel PDX series, and analyse the topological properties of the inferred trees. …”
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A versatile cell line for establishing potency of cell type-specific AAV transgenes by Refugio A. Martinez, Yemeserach M. Bishaw, Meagan A. Quinlan, Erin L. Groce, Bryan B. Gore, Ed S. Lein, John K. Mich, Boaz P. Levi

“…Potency assays are essential for adeno-associated virus (AAV) therapy development, allowing simple and quantitative assessments of therapeutic activity, target engagement, vector stability, and activity per batch. However, cell culture-based AAV potency assays are generally hampered by two limitations: (1) commonly used cell lines have low AAV transduction efficiency due to their lack of appropriate surface receptors, and (2) cell type-specific AAV transgenes are often not expressed because their regulatory elements (enhancers, promoters, etc.) may not be active in the cell lines used for testing. …”
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Coupling Solvent Extraction Units to Cyclic Adsorption Units by Mariana Busto, Enrique Eduardo Tarifa, Carlos Román Vera

“…Regeneration of the solvent by cyclic adsorption had a low heat duty. Values of 174 kJ per litre of solvent compared well with the high values for vaporization of the whole extract phase (1011 kJ L−1).…”
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Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures by Maria Pina Dore, Vincenza Tadeu, Bianca Are, Ida Mura, Giuseppe Fanciulli, Giovannino Massarelli, Andrea Piana

“…Ciprofloxacin-based therapy cured 65% (22/34) of patients by intention to treat and 69% (22/32) per protocol analysis. The prevalence of ciprofloxacin resistance was 8%. …”
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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study by Hellen Livia Drumond Marra, Martin Luiz Myczkowski, Cláudia Maia Memória, Débora Arnaut, Philip Leite Ribeiro, Carlos Gustavo Sardinha Mansur, Rodrigo Lancelote Alberto, Bianca Boura Bellini, Adriano Alves Fernandes da Silva, Gabriel Tortella, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Orestes Vicente Forlenza, Marco Antonio Marcolin

“…Thirty-four elderly outpatients meeting Petersen’s MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. …”
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Evaluation of the Environmental Performance of Seasonal Spaces in the Vernacular Architecture of the Regions With Cold Climate: A Case Study in Ardabil by Marjaneh Kharrat Sadeghi, Mahsa Javadi Nodeh, Mehrdad Sarabi

“…Conclusion: The application of climate-responsive strategies, particularly passive solar designs during winter, in the construction of traditional houses was estimated to reduce CO₂ emissions by 218.47 kg and natural gas consumption by 82.07 kg per month for every 100 m² of space during the cold seasons. …”
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Exploring Methacrylated Gellan Gum 3D Bioprinted Patches Loaded with Tannic Acid or L-Ascorbic Acid as Potential Platform for Wound Dressing Application by Federica Scalia, Alessandra Maria Vitale, Domiziana Picone, Noemi De Cesare, Maria Swiontek Brzezinska, Beata Kaczmarek-Szczepanska, Alfredo Ronca, Barbara Zavan, Fabio Bucchieri, Marta Anna Szychlinska, Ugo D’Amora

“…The cytocompatibility of the patches was demonstrated by direct and indirect tests on human dermal fibroblasts (HDF) as per ISO 10993. The positive effect of GGMA patches on cell migration was assessed through a wound healing assay. …”
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Functional ecology characteristics of key community-forming aquatic and semi-aquatic plant species in Teletskoye Lake (Republic of Altai, Russia) by Laura M. Kipriyanova, Diana V. Sityaeva, Sergei A. Rosbach

“…The highest specific leaf area (SLA) values (leaf area per unit mass) were found in true aquatic plants – hydrophytes. …”
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A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination by Katarzyna Sznajder-Katarzyńska, Magdalena Surma, Iwona Cieślik

“…Per- and polyfluoroalkyl substances (PFASs) are widely distributed across the world and are expected to be of concern to human health and the environment. …”
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Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study by Ting-Chun Fang, Yu-Hsuan Wu, Yi-Huei Chen, Ching-Heng Lin, Ming-Hong Chang

“…The incident rate of dementia was 29.2 (per 1000 person-years) in the PD only group and 13.2 in the PD with depression group. …”
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Revised safety evaluation of the food enzyme endo‐1,4‐β‐xylanase from the genetically modified Bacillus subtilis strain LMG S‐24584 produced by a modified process by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Silvia Peluso, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Gomes, Natalia Kovalkovicova, Yi Liu

“…Dietary exposure is estimated to be up to 0.010 mg TOS/kg body weight per day in European populations. As no concerns arising from the microbial source and its genetic modifications or from the manufacturing process have been identified, the Panel considered that toxicological tests were not needed for the assessment of this food enzyme. …”
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Valorization of raw papaya (Carica papaya) and citrus peels for development of antimicrobial and biodegradable edible film by Prathamesh Pawle, Surabhi Pandey, Arvind Kumar, Aparna Agarwal, Abhishek Dutt Tripathi, Mohd Saeed, Safia Obaidur Rab, Dipendra Kumar Mahato, Pradeep Kumar, Madhu Kamle

“…The films were subjected to various parameter analysis like thickness, optical properties and barrier properties. As per the results, T3 was an optimized film, as it had minimum thickness (0.26 ± 0.01), high tensile strength (5.79 ± 0.12), elongation at break of 11.92 ± 0.03, High transparency (1.42 ± 0.06), and high degradation temperature. …”
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Comparative Antiviral Efficacy of Generic Sofosbuvir versus Brand Name Sofosbuvir with Ribavirin for the Treatment of Hepatitis C by L. Tang, M. Kamat, A. Shukla, M. Vora, C. Kalal, S. Kottilil, S. Shah

“…Monitoring viral loads and safety labs was performed as per national guidelines. Results. Sustained virologic response was 72.4% versus 75.7% (p=0.78) among patients treated with generics and SOVALDI, respectively. …”
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Unmasking health determinants and health outcomes for urban First Nations using respondent-driven sampling by J Smylie, M Firestone, S Maracle, M Spiller, P O'Campo

“…The main objective of the Our Health Counts (OHC) project was to work in partnership with Aboriginal stakeholders to generate a culturally relevant, representative baseline health data set for three urban Aboriginal communities in Ontario, Canada.Design Respondent-driven sampling (RDS).Setting Hamilton, Ontario, Canada.Participants The OHC study, in partnership with the De dwa da dehs ney >s Aboriginal Health Access Centre (DAHC), recruited 554 First Nations adults living in Hamilton using RDS.Results Among First Nations adults living in Hamilton, 78% earned less than $20 000 per year and 70% lived in the lowest income quartile neighbourhoods. …”
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Analysis of graphene coatings on various metallic/oxide crystal/composite material substrates using machine learning for enhanced solar thermal energy conversion by Khaled Aliqab, Dhruvik Agravat, Shobhit K. Patel, Ammar Armghan, Naim Ben Ali, Meshari Alsharari

“…Thus, the data collection time is greatly reduced using ML compared to running simulations which have a step size of about 8 h per change. Where the machine learning efficacy is 98% for the thickness optimization of Fe, CuO, and MAPBI3 with 25% test data. …”
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