The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China by Mingchen Zhang, Jiangfeng Mao, Ablikm Tuerdi, Xiaoyun Zeng, Li Quan, Shan Xiao, Jun Zhu, Hua Yao

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Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors by Yuhui Yang, Yuhui Yang, Yuhui Yang, Pingping Long, Pingping Long, Ying Tuo, Ying Tuo, Xiaoxiao Wang

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SiCLAT: simultaneous imaging of chromatin loops and active transcription in living cells by Xin Wan, Jie Kong, Xiaodi Hu, Lulu Liu, Yuanping Yang, Hu Li, Gaoao Liu, Xingchen Niu, Fengling Chen, Dan Zhang, Dahai Zhu, Yong Zhang

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Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

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Tumor-Stroma Ratio is a Critical Indicator of Peritoneal Metastasis in Gastric Cancer by Zhong L, Huang H, Hou D, Zhou S, Lin Y, Yu Y, Yu J, Han F, Xie L

“…Lin Zhong,1,* Hongyun Huang,2,* Dong Hou,1,* Shihai Zhou,3 Yu Lin,4 Yue Yu,4 Jinhao Yu,1 Fanghai Han,5 Lang Xie6 1Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, People’s Republic of China; 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100010, People’s Republic of China; 3Department of Tumor Surgery, Zhongshan City People’s Hospital, Zhongshan, Guangdong, 528403, People’s Republic of China; 4Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, People’s Republic of China; 5Department of Gastrointestinal Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, 5181025, People’s Republic of China; 6Department of General surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lang Xie; Fanghai Han, Email langxiezj@hotmail.com; fh_han@163.comObjective: This study aims to investigate the correlation between the tumor-stroma ratio (TSR) and peritoneal metastasis (PM) in gastric cancer (GC) and constructs a diagnostic model based on preoperative examination data.Methods: To determine the feasibility of obtaining TSR in GC patients through preoperative examinations, the consistency of TSR between endoscopic biopsy tissues and postoperative histopathological tissues was evaluated. …”
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Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

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Application of solid-phase extraction and gas chromatography-mass spectrometry (SPE-GC-MS) in resolution of metabolism pattern of higher alcohols in rat plasma by Yufei Liu, Xiaonian Cao, Zhilei Zhou, Qingxi Ren, Zhongwei Ji, Min Gong, Yuezheng Xu, Weibiao Zhou, Shuguang Chen, Jian Mao

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Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study by Biling Gan, Lei Wu, Shunan Zhou, Zhihong Chen, Fan Wu, Lianqun Xu, Zhenrong Chen, Honghui Ma, Peijia He, Dan Fang, Ning Shi

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Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Xiuqi Li,1,* Shupeng Liu,1,* Mengyang Yu,1 Wanlin Xi,1 Xiaofei Wu,1 Dan Liu,2 Aijing Liu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyun Wang, Email wanghy@pumch.cnBackground: Proton pump inhibitors (PPIs) and potassium competitive acid blockers (P-CABs) are widely used to treat acid-related diseases (ARDs). …”
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Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer by Yu-Zhong Yu, Xiao Xie, Mao-Ping Cai, Ya-Ying Hong, Yang-Zi Ren, Xi Kang, Hai-Chen Yan, Yang Xiong, Hong Chen, Xing-Cheng Wu, Dao-Sheng Luo, Shan-Chao Zhao

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Evidence Graph Analysis of Postoperative Pain Sensitization Induced by Perioperative Sleep Deprivation by XUE Jianjun, WANG Caihong, GUO Lingling, LI Xiuxia, ZHANG Jie, XU Ziqing, HOU Huaijing, YANG Kehu

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Inpatient autopsy rate and associated factors in a Chinese megacity: a population-based retrospective cohort study by Yu Wang, Jiming Zhu, Zihan Wang, Dachun Zhao, Hange Li, Yanrong He, Xidong Guo, Hanbo Zhang, Huatang Zeng

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Clinical and Immunological Characteristics of Elderly Onset Rheumatoid Arthritis by LI Zhengfang, WU Chanyuan, MA Mengsi, LI Tingting, WU Xue, MENG Xinyan, ZHANG Sha, WU Lijun

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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

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Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study by Yong Zhou, Jiayue Duan, Jiayi Zhu, Yunying Huang, Tao Tu, Keke Wu, Qiuzhen Lin, Yingxu Ma, Qiming Liu

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Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson’s Disease: A Pilot Stud... by Haiyan Zhou, Shuhua Li, Hongmei Yu, Shenggang Sun, Xinhua Wan, Xiaodong Zhu, Chun-Feng Liu, Ling Chen, Wei Xiang, Yaqing Sun, Haibo Chen, Shengdi Chen

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A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA by Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua Zhao

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The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) by Wei Xiong, Qinghan Liang, Xiaojie Han, Qiaolu Cheng, Qihang Liu, Xifang Zuo, Huiyu Wang, Huijing He, Guangliang Shan

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Effect of comorbidity classes on survival of patients with gastrointestinal tract cancer by Linna Gao, Tian Yao, Shaohua Ge, Jiuwei Cui, Wei Li, Zengqing Guo, Hongxia Xu, Min Weng, Suyi Li, Qinghua Yao, Wen Hu, Lan Zhou, Junqiang Chen, Xianghua Wu, Qingchuan Zhao, Hongli Li, Hanping Shi, Yi Ba, He Huang, The Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group

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Is training policy for general practitioners in China charting the right path forward? a mixed methods analysis by Li Luo, Chen Chen, Wenya Yu, Qian Liu, Chunhua Chi, Yan Yang, Rui Liu, Jianwei Shi, Dehua Yu, Hua Jin, Zhaoxin Wang, Qingfeng Du, Xin Gong, Jiaoling Huang, Ning Chen

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