Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

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Tumor-Stroma Ratio is a Critical Indicator of Peritoneal Metastasis in Gastric Cancer by Zhong L, Huang H, Hou D, Zhou S, Lin Y, Yu Y, Yu J, Han F, Xie L

“…Lin Zhong,1,* Hongyun Huang,2,* Dong Hou,1,* Shihai Zhou,3 Yu Lin,4 Yue Yu,4 Jinhao Yu,1 Fanghai Han,5 Lang Xie6 1Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, People’s Republic of China; 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100010, People’s Republic of China; 3Department of Tumor Surgery, Zhongshan City People’s Hospital, Zhongshan, Guangdong, 528403, People’s Republic of China; 4Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, People’s Republic of China; 5Department of Gastrointestinal Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, 5181025, People’s Republic of China; 6Department of General surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lang Xie; Fanghai Han, Email langxiezj@hotmail.com; fh_han@163.comObjective: This study aims to investigate the correlation between the tumor-stroma ratio (TSR) and peritoneal metastasis (PM) in gastric cancer (GC) and constructs a diagnostic model based on preoperative examination data.Methods: To determine the feasibility of obtaining TSR in GC patients through preoperative examinations, the consistency of TSR between endoscopic biopsy tissues and postoperative histopathological tissues was evaluated. …”
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Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Yunfu Chen,1,* Guangling Tang,1,* Jun Lu,1,* Sijie Tang,1 Xinglong Xiong,1 Chao Chen,1 Lijian Pei,2 Jing Shi1 1Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guizhou, People’s Republic of China; 2Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Shi, Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China, Tel +86-18685034016, Email shijing81@gmc.edu.cn Lijian Pei, Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China, Email hazelbeijing@vip.163.comBackground: The neuropathic pain side induced by Vincristine severely limit its clinical application. …”
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Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

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Application of solid-phase extraction and gas chromatography-mass spectrometry (SPE-GC-MS) in resolution of metabolism pattern of higher alcohols in rat plasma by Yufei Liu, Xiaonian Cao, Zhilei Zhou, Qingxi Ren, Zhongwei Ji, Min Gong, Yuezheng Xu, Weibiao Zhou, Shuguang Chen, Jian Mao

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Thyroid nodule rupture after thermal ablation for benign thyroid nodules: incidence, risk factors, and clinical management by Yu-tong Liu, Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Yan Li, Li-Li Peng, Ming-an Yu

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A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma by Jie Zha, Qinwei Chen, Wei Zhang, Hongmei Jing, Jingjing Ye, Huanhuan Liu, Haifeng Yu, Shuhua Yi, Caixia Li, Zhong Zheng, Wei Xu, Zhifeng Li, Zhijuan Lin, Lingyan Ping, Xiaohua He, Liling Zhang, Ying Xie, Feili Chen, Xiuhua Sun, Liping Su, Huilai Zhang, Haiyan Yang, Weili Zhao, Lugui Qiu, Zhiming Li, Yuqin Song, Bing Xu

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Editorial: Immunity and pulmonary vascular diseases: challenges, advances and future perspectives by Qi Jin, Qi Jin, Daxin Zhou, Daxin Zhou, Zhihong Liu, Djuro Kosanovic

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Research Progress of Perioperative Anesthesia Management in Patients with Hypertrophic Cardiomyopathy by LIN Shuantong, SU Xiaojun, CAO Dequan

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Stakeholder Preference Assessment in Implementation Research: Application of Best-worst Scaling by MAO Run, CAI Yiyuan, YANG Wei, LIU Zhiguo, LINGHU Lang, CHEN Jiajia, LIANG Mengjiao, HUANG Lieyu, LIU Siyuan, XU Dong

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Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study by Ying Fan, Qingyuan Zhang, Min Yan, Xiujuan Qu, Yongmei Yin, Tao Sun, Jin Yang, Ying Wang, Xu Wang, Zhaofeng Niu, Xinshuai Wang, Sanyuan Sun, Weihong Zhao, Yanping Liu, Miao Niu, Xuemin Zhao, Binghe Xu

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Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells by Guixian Liang, Shicheng Liu, Chunyu Zhou, Mengyao Liu, Yifan Zhang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, Feng Liu

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Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study by Biling Gan, Lei Wu, Shunan Zhou, Zhihong Chen, Fan Wu, Lianqun Xu, Zhenrong Chen, Honghui Ma, Peijia He, Dan Fang, Ning Shi

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Effect of Aerobic Exercise on Blood Glucose Among Those with Prediabetes: A Systematic Review and Meta-Analysis by Tianyi Jiang, Zichen Ye, Qu Lu, Peixia Cheng, Qi Gao

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The Prognostic Value of CRP/Alb Ratio in Predicting Overall Survival for Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Combined with Molecular-Targeted... by Huang X, Peng G, Kong Y, Cao X, Zhou X

“…Xiaoyu Huang, Gang Peng, Yaqing Kong, Xiaojing Cao, Xiang Zhou Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People’s Republic of ChinaCorrespondence: Xiang Zhou, Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People’s Republic of China, Email zhou.xiang@yeah.netPurpose: This study aimed to evaluate the prognostic value of C-reactive protein to albumin (CRP/Alb) ratio in hepatocellular carcinoma (HCC) treated with transcatheter intra-arterial therapy combined with molecular targeted agents (MTAs) and programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors.Methods: Medical records of 271 consecutive patients with HCC receiving this combination therapy in China between 2019 and 2023 were retrospectively analyzed. …”
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Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway by Yumei Rong, Yumei Rong, Yumei Rong, Yumei Rong, Yumei Rong, Minghui Zhu, Minghui Zhu, Minghui Zhu, Minghui Zhu, Nan Wang, Nan Wang, Nan Wang, Nan Wang, Feiyu Zhang, Feiyu Zhang, Feiyu Zhang, Feiyu Zhang, Tianjun Liu

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Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Xiuqi Li,1,* Shupeng Liu,1,* Mengyang Yu,1 Wanlin Xi,1 Xiaofei Wu,1 Dan Liu,2 Aijing Liu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyun Wang, Email wanghy@pumch.cnBackground: Proton pump inhibitors (PPIs) and potassium competitive acid blockers (P-CABs) are widely used to treat acid-related diseases (ARDs). …”
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Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer by Yu-Zhong Yu, Xiao Xie, Mao-Ping Cai, Ya-Ying Hong, Yang-Zi Ren, Xi Kang, Hai-Chen Yan, Yang Xiong, Hong Chen, Xing-Cheng Wu, Dao-Sheng Luo, Shan-Chao Zhao

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Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study by Juan Wu, Xin-yu Liang, Lei Hu, Ying Li, Liang Ran, Rui-ling She, Xiu-quan Qu, Bai-qing Peng, Kai-nan Wu, Jing Wang, Ling-quan Kong

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Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomize... by Binghe Xu, Qingyuan Zhang, Yang Luo, Zhongsheng Tong, Tao Sun, Changping Shan, Xinlan Liu, Yumin Yao, Bing Zhao, Shusen Wang, Xiaohua Zeng, Changlu Hu, Xi Yan, Xiaojia Wang, Hongyan Jia, Zhendong Chen, Fuming Qiu, Xinhong Wu, Deyong Zhang, Tong Li

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