Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study by Zucca G, Vigani B, Valentino C, Ruggeri M, Marchesi N, Pascale A, Giovilli G, Malavasi L, Sandri G, Rossi S

“…Gaia Zucca,1 Barbara Vigani,1 Caterina Valentino,1 Marco Ruggeri,1 Nicoletta Marchesi,1 Alessia Pascale,1 Giulia Giovilli,2 Lorenzo Malavasi,2 Giuseppina Sandri,1 Silvia Rossi1 1Department of Drug Sciences, University of Pavia, Pavia, 27100, Italy; 2Department of Chemistry and INSTM, University of Pavia, Pavia, 27100, ItalyCorrespondence: Silvia Rossi; Barbara Vigani, Department of Drug Sciences, University of Pavia, Via Taramelli 12, Pavia, 27100, Italy, Email silvia.rossi@unipv.it; barbara.vigani@unipv.itPurpose: The main purpose of the study was the formulation development of nanogels (NHs) composed of chondroitin sulfate (CS) and low molecular weight chitosan (lCH), loaded with a naringenin-β-cyclodextrin complex (NAR/β-CD), as a potential treatment for early-stage diabetic retinopathy.Methods: Different formulations of NHs were prepared by varying polymer concentration, lCH ratio, and pH and, then, characterized for particle size, zeta potential, particle concentration (particles/mL) and morphology. …”
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Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes by Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi

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Release velocity ImprovemenT with a new Metronome guIding chest COmpressions: The RITMICO simulation study by Maria Luce Caputo, Giuliana Monachino, Ruggero Cresta, Alessia Currao, Enrico Baldi, Simone Savastano, Andrea Cortegiani, Mariachiara Ippolito, Sara Accetta, Alessandra Gargano, Camilla Metelmann, Bibiana Metelmann, Carlos Ramon Hölzing, Julian Ganter, Michael Patrick Müller, Claudio Benvenuti, Stefania Tomola, Pierangelo Pinetti, Pier Luigi Ingrassia, Francesca Dalia Faraci, Angelo Auricchio

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Clock/Frequency Generation Circuits and Systems by Woogeun Rhee, Antonio Liscidini, Jae-Yoon Sim, Kenichi Okada, Sudhakar Pamarti

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Cost–Benefit Analysis of in vivo Reflectance Confocal Microscopy for Melanoma Diagnosis in a Real-World Clinical Setting by Bruno GM, Di Matteo S, Longo C, Stanganelli I, Farnetani F, Borsari S, Mazzoni L, Ciardo S, Raucci M, Magi S, Bassoli S, Spadafora M, Mandel VD, Casari A, Chester J, Kaleci S, Colombo GL, Pellacani G

“…Giacomo Matteo Bruno,1 Sergio Di Matteo,2 Caterina Longo,3,4,* Ignazio Stanganelli,5,6,* Francesca Farnetani,7 Stefania Borsari,3 Laura Mazzoni,5 Silavana Ciardo,7 Margherita Raucci,3 Serena Magi,5 Sara Bassoli,7 Marco Spadafora,3,8 Victor Desmond Mandel,9 Alice Casari,7 Johanna Chester,7 Shaniko Kaleci,7 Giorgio Lorenzo Colombo,10 Giovanni Pellacani11 1Department of Drug Sciences, University of Pavia, Pavia, Italy; 2S.A.V.E. Studi Analisi Valutazioni Economiche S.r.l., Health Economics & Outcomes Research, Milan, Italy; 3Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, Italy; 4Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; 5Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola, Italy; 6Department of Medicine and Surgery, University of Parma, Parma, Italy; 7Dermatology Unit, Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, University of Modena and Reggio Emilia, Modena, 41125, Italy; 8Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy; 9Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, Roma, Italy; 10Department of Drug Sciences, CEFAT-Center of Pharmaceuticals Economics and Medical Technologies Evaluation, University of Pavia, Pavia, Italy; 11Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Dermatology Clinic, Sapienza University of Rome, Rome, Italy*These authors contributed equally to this workCorrespondence: Giacomo Matteo Bruno, Department of Drug Sciences, University of Pavia, Pavia, Italy, Email giacomomatteo.bruno@unipv.itBackground: In a recent prospective, multicenter, two-arm randomized controlled trial (RCT), we demonstrated that adjunctive reflectance confocal microscopy (RCM) in routine clinical practice provides clinical benefits, including safe melanoma detection and a 43.3% reduction in the number needed to excise (NNE).Methods: A cost–benefit analysis was conducted based on NNEs for standard care (5.3) and adjunctive RCM (3.0). …”
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A dataset for large prismatic lithium-ion battery cells (CALB L148N58A): Comprehensive characterization and real-world driving cyclesCALB L148N58A testing campaign by Simone Fasolato, Nicola Blasuttigh, Giacomo Galuppini, Davide M. Raimondo

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Asymptotic analysis for vanishing acceleration in a thermoviscoelastic system by Elena Bonetti, Giovanna Bonfanti

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Direct Dark Matter Search by Anselmo Meregaglia, Davide Franco, Marcello Messina, Claudio Montanari, Francesco Pietropaolo

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Implications of hormonal carcinogenesis for transgender and gender-diverse people undergoing gender-affirming hormone therapy: an up-to-date review by Matteo Lambertini, Filippo Pietrantonio, Dario Trapani, Francesco Perrone, Rossana Berardi, Saverio Cinieri, Chiara Cassani, Amelia Barcellini, Filippo Ghelardi, Alberto Giovanni Leone, Stefania Bonadonna, Marianna Sirico, Barbara Tagliaferri, Stefano Maccarone, Davide Dalu, Lorenzo Ruggieri, Simone Nardin, Nicla La Verde

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Are socio-economic inequalities related to cardiovascular disease risk? A systematic review and meta-analysis of prospective studies by Ololade J. Baruwa, Federica Alberti, Sunday Onagbiye, Annalisa Guddemi, Anna Odone, Hannah Ricci, Maddalena Gaeta, Schmid Daniela, Cristian Ricci

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Milestones and Timescale of Poststroke Recovery: A Cohort Study by Marianna Loi, Alberto Zaliani, Marta Abbamonte, Elena P. Ferrari, Roberto Maestri, Luigi Trojano, Pietro Balbi

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Exploring Inhibitory Control Processes in Highly Superior Autobiographical Memory (HSAM): A Single Case Study by Jessica Talbot, Daniele Gatti, Marta Boccalari, Michela Marchetti, Danilo Mitaritonna, Gianmarco Convertino, Mara Stockner, Giuliana Mazzoni

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Corrigendum to “Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems” by Veronica Dusi, Alice Ghidoni, Alice Ravera, Gaetano M. De Ferrari, Laura Calvillo

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Nonperturbative Uncertainties on the Transverse Momentum Distribution of Electroweak Bosons and on the Determination of the W Boson Mass at the LHC by Giuseppe Bozzi, Andrea Signori

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Permanent aquifer storage loss from long-term groundwater withdrawal: A case study of subsidence in Bandung (Indonesia) by Michelle Rygus, Marco Bianchi, Alessandro Novellino, Ekbal Hussain, Ahmad Taufiq, Steven Reinaldo Rusli, Dwi Sarah, Claudia Meisina

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Understanding the Seismic Resilience of Metallic Cylindrical Tanks Through Parametric Analysis by Emanuele Brunesi, Roberto Nascimbene, Dumitru Beilic

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Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study by Serena Tagliente, Brigida Minafra, Simona Aresta, Simona Aresta, Paola Santacesaria, Andrea Buccoliero, Cinzia Palmirotta, Gianvito Lagravinese, Davide Mongelli, Christian Gelao, Luigi Macchitella, Stefania Pazzi, Domenico Scrutinio, Paola Baiardi, Petronilla Battista

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Swallowing Disorders after Oral Cavity and Pharyngolaryngeal Surgery and Role of Imaging by Caterina Giannitto, Lorenzo Preda, Valeria Zurlo, Luigi Funicelli, Mohssen Ansarin, Salvatore Di Pietro, Massimo Bellomi

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Electronic Structure and Magnetic Coupling of Pure and Mg-Doped KCuF3 by Fausto Cargnoni, Simone Cenedese, Paolo Ghigna, Mario Italo Trioni, Marco Scavini

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Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study by Ilaria Maestrini, Marta Altieri, Laura Di Clemente, Edoardo Vicenzini, Patrizia Pantano, Eytan Raz, Mauro Silvestrini, Leandro Provinciali, Isabella Paolino, Carmine Marini, Matteo Di Giuseppe, Tommasina Russo, Francesco Federico, Cristiana Coppola, Maria Pia Prontera, Domenico Maria Mezzapesa, Vincenzo Lucivero, Lucilla Parnetti, Paola Sarchielli, Maria Peducci, Domenico Inzitari, Giovanna Carlucci, Carlo Serrati, Carla Zat, Anna Cavallini, Alessandra Persico, Giuseppe Micieli, Stefano Bastianello, Vittorio Di Piero

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