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1701
REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)
Published 2018-01-01“…This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.…”
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1702
Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance
Published 2025-11-01“…Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms. Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson’s disease through the dysregulation of several pathological processes. …”
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1703
Unilateral Upper Cervical Posterior Spinal Cord Infarction after a Neuroendovascular Intervention: A Case Report
Published 2018-01-01“…We describe a case of unilateral posterior upper cervical spinal cord infarction and propose a pathophysiologic mechanism causing this lesion after vertebral artery endovascular intervention. …”
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1704
Critical evaluation of pathogenic factors of primary biliary cirrhosis
Published 2013-07-01“…Despite of sufficient progress in studying of main pathophysiological mechanisms of PBC, etiology of disease remains obscure. …”
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1705
Discussion of irritable bowel syndrome issue and functional constipations in reports of the 21st United European Gastroenterological Week (Berlin, 2013)
Published 2014-09-01“…The range of pharmaceuticals has been replenished by new agents (linaclotide, prucalopride), increasing efficacy of IBS and CFC treatment.Conclusion. Pathophysiological and clinical aspects of IBS and CFC require further investigation.…”
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1706
Triggers for Atrial Fibrillation: The Role of Anxiety
Published 2019-01-01“…The present review sought to underline the possible pathophysiological association between AF and anxiety disorders and suggests that anxiety can be an independent risk factor for AF, acting as a trigger, creating an arrhythmogenic substrate, and modulating the autonomic nervous system. …”
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1707
The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion
Published 2018-01-01“…Ischemia-reperfusion (I/R) injury is a well-known phenomenon that involves different pathophysiological processes. Connection in diverse systems of survival brings about cellular dysfunction or even apoptosis. …”
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1708
Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism
Published 2025-01-01“…Additionally, we examine the potential pathophysiological mechanisms underlying the psychosis of epilepsy from three perspectives: neuroimaging, neurobiology, and genetics. …”
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1709
The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?
Published 2012-01-01“…This paper first describes the expression of the vasoconstrictive arm of RAS components in the brain as well as their physiological and pathophysiological significance. It then focus on the (pro)renin receptor (PRR), a newly discovered component of the RAS which has a high level in the brain. …”
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1710
Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment
Published 2025-02-01“…This review examines clinical and translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms of MetS and MCI. By addressing inflammation, oxidative stress, and metabolic dysfunction, these supplements may offer a valuable approach to mitigating the progression and consequences of both conditions. …”
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1711
Intricating connections: the role of ferroptosis in systemic lupus erythematosus
Published 2025-02-01“…Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. …”
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1712
Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease
Published 2024-12-01“…New studies are necessary to clarify the pathophysiological bases of Parkinson's disease that allow establishing future therapeutic strategies for the follow-up of patients with these disorders.…”
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1713
Oxidative Stress and Its Biomarkers in Cardiovascular Diseases
Published 2024-10-01“…CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. …”
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1714
Leukotrienes as Modifiers of Preclinical Atherosclerosis?
Published 2012-01-01“…Preclinical atherosclerosis represents a crucial period associated with several pathophysiological reactions in the vascular wall. Failure to diagnose preclinical atherosclerosis at this stage misses a major opportunity to prevent the long-term consequences of this disease. …”
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1715
The Enigma of the Tinnitus-Free Dream State in a Bayesian World
Published 2014-01-01“…There are pathophysiological, clinical, and treatment analogies between phantom limb pain and phantom sound (i.e., tinnitus). …”
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1716
Physiopathological Mechanisms of Association between Metabolic Syndrome and Arterial Hypertension: an Update
Published 2023-02-01“…The objective was to argue the pathophysiological mechanisms of association between the metabolic syndrome and arterial hypertension. …”
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1717
PATHOGENETIC ROLE OF THROMBOCYTES IN THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND
Published 2018-12-01“…According to the results of our study, we hypothesized that PMPs can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response.…”
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1718
Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy
Published 1990-01-01“…Medical treatment of short bowel syndrome remains supportive and centres around the control of three pathophysiological defects: decreased intestinal transit time, gastric hypersecretion, and reduced functional mucosal surface area.…”
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1719
Multivessel Coronary Artery Vasospasm-Induced Takotsubo Cardiomyopathy
Published 2022-01-01“…Epicardial coronary vasospasm is a rarely reported etiology for takotsubo cardiomyopathy, and its pathophysiologic mechanisms still remain incompletely understood. …”
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1720
Progress on Development and Rehabilitation Mechanism of Upper Extremity Lymphedema after Radical Mastectomy
Published 2017-12-01“…The results showed that upper limb overload, trauma and infection were the most common causes of upper limb lymphedema, and surgical methods, postoperative radiotherapy and chemotherapy, tumor recurrence, obesity and so on were considered as related risk factors. The main pathophysiological mechanisms of upper limb lymphedema were the destruction of lymphatic vessels, the obstruction of lymphatic circulation, and the retention of extracellular fluid in the interstitial space. …”
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