Deciphering Metabolic Responses in Traumatic Brain Injury Patients With Different Severity Using 1H NMR-Based Serum Metabolomics by Huan Zhou, Dongdong Sun, Dongmei Wang, Zirui Zhu, Xuelian Hong, Rui Fang, Hua Wang, Minghui Li

“…In order to elucidate the underlying pathophysiologic mechanisms and identify serum biomarkers associated with TBI, we conducted a comprehensive investigation utilizing a 1H nuclear magnetic resonance (NMR)–based metabolomics approach and ELISA analysis of serum samples obtained within 24 h postinjury from a cohort of participants with varying degrees of TBI severity. …”
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Regulation of (Pro)Renin Receptor in Renin-Positive Smooth Muscle Cells of Kidney Arterioles in Rats with STZ-Induced Diabetes by Zsolt Razga, Gabor Kovacs, Nikolett Bódi, Petra Talapka, Mária Bagyánszki

“…The nephron (pro)renin receptor may play a pathophysiological role in renal disorders in hypertension or diabetes. …”
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Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study by Huaying Cai, Zhiyong Zhao, Linhui Ni, Guocan Han, Xingyue Hu, Dan Wu, Xianjun Ding, Jin Wang

“…Our findings suggest that PSD patients show dementia-specific structural and functional alteration patterns, which may help elucidate the pathophysiological mechanisms underlying PSD.…”
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Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure by Patrick Geraghty, Nathalie Baumlin, Matthias A. Salathe, Robert F. Foronjy, Jeanine M. D’Armiento

“…Therefore, ER stress may be an antioxidant-related pathophysiological event in COPD.…”
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Identification of molecular characteristics in polycystic ovary syndrome using single-cell and transcriptome analysis by Xiaolin Zhu, Yanhua Han, Yuenan Feng, Yuanli Shan, Chang Liu, Kexin Wang, Xiaoke Li, Shidi Zhang, Yaguang Han

“…Our study, by analyzing multiple datasets, has revealed the complex molecular network of PCOS, offering new insights into understanding its pathophysiological basis.…”
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Dysregulation in the microbiota by HBV and HCV infection induces an altered cytokine profile in the pathobiome of infection by Marcos Daniel Mendes Padilha, Francisco Tiago de Vasconcelos Melo, Rogério Valois Laurentino, Andrea Nazaré Monteiro Rangel da Silva, Rosimar Neris Martins Feitosa

“…In view of the above, this review aimed to correlate the pathophysiological mechanisms in HBV and HCV infection, the dysregulation of the microbiome in patients infected with HBV and HCV, the most altered cytokines in the microbiome, and the most altered bacterial representatives in the pathobiome of infection.…”
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Abnormal Expression of Connexin43 in Cardiac Injury Induced by S-Band and X-Band Microwave Exposure in Rats by Yue Yin, Xinping Xu, Yabing Gao, Juan Wang, Binwei Yao, Li Zhao, Haoyu Wang, Hui Wang, Ji Dong, Jing Zhang, Ruiyun Peng

“…In this study, we will investigate the damaging effect of S-band and X-band microwave composite exposure on cardiac structure and function, as well as the pathophysiological significance of Cx43 in cardiac conduction dysfunction after exposure. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…Remarkably, the dysregulation in endosomal trafficking is emerging as a pathophysiological mechanism underlying peripheral neuropathies, such as demyelinating Charcot‐Marie‐Tooth (CMT) diseases. …”
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Gut microbial 3α‐hydroxysteroid dehydrogenase promotes depression in males via degrading testosterone by Di Li, Jingru Cheng, Wei Zhang, Pengfei Cheng, Yuan He, Jinghan Jia, Chao Wang, Zhongchun Liu, Zhou Sun, Jinxi Wang

“…Abstract Abnormal gut microbiota is associated with the occurrence of depression, but the specific pathophysiological role of gut microbiota in the pathogenesis of depression is still unknown. …”
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New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness by Giuseppe Spaziano, Donato Cappetta, Konrad Urbanek, Elena Piegari, Grazia Esposito, Maria Matteis, Manuela Sgambato, Gioia Tartaglione, Rosa Russo, Raffaele De Palma, Francesco Rossi, Antonella De Angelis, Bruno D’Agostino

“…These data document previously unrecognized properties of c-kit+ cells, able to impede pathophysiological features of experimental airway hyperresponsiveness.…”
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Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum by Alessandra Puddu, Roberta Sanguineti, Arianna Durante, Alessio Nencioni, François Mach, Fabrizio Montecucco, Giorgio L. Viviani

“…Advanced glycation end products (AGEs) might play a pathophysiological role in the development of diabetes and its complications. …”
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Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…<b>Results</b>: The activity of Reg proteins is not as simplistic as previously perceived but shows auto-immunogenicity depending on different pathophysiological microenvironments. The immunogenicity of Reg proteins could recruit immune cells leading to an anti-tumor effect. …”
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Acute Kidney Injury Caused by Obstructive Nephropathy by Jonathan S Chávez-Iñiguez, Goretty J Navarro-Gallardo, Ramón Medina-González, Luz Alcantar-Vallin, Guillermo García-García

“…In this review, we report the epidemiology, incidence, pathophysiological mechanisms, diagnosis, and treatment of acute kidney injury due to obstructive nephropathy.…”
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Diagnosis and Treatment of Low Anterior Resection Syndrome by Masaaki Miyo, Emi Akizuki, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Ichiro Takemasa

“…Recent findings have indicated that multiple pathophysiological changes, including reservoir function and evacuation of the neorectum, anal sphincter function, negative impact of a diverting stoma, autonomic denervation, and radiotherapy, are involved in the etiology of LARS. …”
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Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions by Stefania Kalampokini, Anouck Becker, Klaus Fassbender, Epameinondas Lyros, Marcus M. Unger

“…Neuroinflammation is increasingly recognized as an important pathophysiological feature of neurodegenerative diseases such as Parkinson’s disease (PD). …”
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Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa, Mathew A. Coban

“…This review provides a comprehensive overview of the pathophysiological roles of gelatinases in CRC, highlighting their contribution to tumor microenvironment modulation, angiogenesis, and the metastatic cascade. …”
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Lewy body diseases and the gut by Timothy R. Sampson, Malú Gámez Tansey, Andrew B. West, Rodger A. Liddle

“…We predict that a better understanding of how pathophysiologies in the gut influence disease risk and progression will accelerate discoveries that will lead to a deeper overall mechanistic understanding of disease and potential therapeutic strategies targeting the gut-brain axis to delay, arrest, or prevent disease progression.…”
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Combined Aerobic and Resistance Exercises Evokes Longer Reductions on Ambulatory Blood Pressure in Resistant Hypertension: A Randomized Crossover Trial by Nayara Fraccari Pires, Helio José Coelho-Júnior, Bruno Bavaresco Gambassi, Ana Paula Cabral de Faria, Alessandra Mileni Versuti Ritter, Catarina de Andrade Barboza, Silvia Elaine Ferreira-Melo, Bruno Rodrigues, Heitor Moreno Júnior

“…In addition, NON-RH and RH people showed different changes on BP after exercise sessions, suggesting that postexercise hypotension is influenced by the pathophysiological bases of hypertension.…”
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Our Experience in Endoscopic Transnasal Optic Nerve Decompression by Saravana Selvan Velmurugan, VIVEK Mariappan, Mohamed Siddique Samsudeen, SURESH KUMAR Narayanan, Asith Jakkiriya Basha, Revathi Subramanian

“…Increased intracanalicular pressure after an injury is considered to be one of the main pathophysiological manifestations.2 Mucoceles involving the Onodi cell and the sphenoidal sinus are rare, and optic nerve compression with decreased visual acuity may be the first presenting symptom.3. …”
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Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice by Elle EM Scheijen, Naomi Veeningen, Sam Duwé, Anna Ivanova, Jana Van Broeckhoven, Sven Hendrix, David M Wilson

“…Nevertheless, the pathophysiological mechanisms leading to neuronal loss following SCI remain incompletely defined. …”
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