Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments by Francesca Lusetti, Camilla Almeida Martins Helfenberger, Munique Kurtz de Mello, Natália Sousa Freitas Queiroz

“…Currently, there is still no consensus on the optimal management for CP, though recent progress in understanding the pathophysiology of pouchitis has paved the way for innovative therapeutic approaches, based on biological therapies and small molecules. …”
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The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model by Junyan Han, Katsuyuki Takeda, Erwin W. Gelfand

“…To study these processes in ways which are not available in humans, animal models have been established and have provided valuable insight into the pathophysiology of RSV-induced disease. In this paper, we discuss experimental models of RSV infection in mice and highlight a new investigative approach in which mice are initially infected as neonates and then reinfected later in life. …”
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Inflammatory Signalling Associated with Brain Dead Organ Donation: From Brain Injury to Brain Stem Death and Posttransplant Ischaemia Reperfusion Injury by Ryan P. Watts, Ogilvie Thom, John F. Fraser

“…Brain death is associated with dramatic and serious pathophysiologic changes that adversely affect both the quantity and quality of organs available for transplant. …”
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Identification of Novel Mutations in Spatacsin and Apolipoprotein B Genes in a Patient with Spastic Paraplegia and Hypobetalipoproteinemia by Leema Reddy Peddareddygari, Raji P. Grewal

“…We report a patient with autosomal recessive (AR) HSP in whom laboratory investigations revealed hypobetalipoproteinemia raising the possibility of a shared pathophysiology of these clinical features. A lipid profile of his parents disclosed a normal maternal lipid profile. …”
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Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity by Urszula Doboszewska, Piotr Wlaź, Gabriel Nowak, Maria Radziwoń-Zaleska, Ranji Cui, Katarzyna Młyniec

“…In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. …”
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CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease by J. Thome, A. N. Coogan, A. G. Woods, C. C. Darie, F. Häßler

“…Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.…”
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Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population by Oksana S. Pogorielova, Viktoriia V. Korniienko, Yaroslav D. Chumachenko, Olha A. Obukhova, Igor Martsovenko, Viktoriia Yu. Harbuzova

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The Complexity of Pain Management in Children Affected by Mucopolysaccharidoses by Sabrina Congedi, Chiara Di Pede, Maurizio Scarpa, Angelica Rampazzo, Franca Benini

“…Pain is a common feature in mucopolysaccharidoses. However, the pathophysiology of pain in this group of diseases is still unclear and genesis of pain is multifactorial. …”
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials by Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas, Fabio Facchinetti

“…Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. …”
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Nosocomial Methemoglobinemia Resulting from Self-Administration of Benzocaine Spray by Christopher Hoffman, Hawa Abubakar, Pramood Kalikiri, Michael Green

“…We review this case in detail in addition to discussing methemoglobinemia and its relevant biochemistry, pathophysiology, clinical presentation, and medical management. …”
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Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases by David H. Tian, Chamini J. Perera, Gila Moalem-Taylor

“…Animal models of experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) mimic many aspects of MS and GBS, respectively, and are well suited to study the pathophysiology of these autoimmune diseases. However, while much attention has been devoted to curative options, research into neuropathic pain mechanisms and relief has been somewhat lacking. …”
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Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? by Arunotai Siriussawakul, Lucinda I. Chen, John D. Lang

“…This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it. …”
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Contemporary Evaluation and Management of the Diabetic Foot by Bauer E. Sumpio

“…Ulcers are breaks in the dermal barrier with subsequent erosion of underlying subcutaneous tissue that may extend to muscle and bone, and superimposed infection is a frequent and costly complication. The pathophysiology of diabetic foot disease is multifactorial and includes neuropathy, infection, ischemia, and abnormal foot structure and biomechanics. …”
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Prospective Five-Year Follow-Up of Patients with Schizophrenia Suspected with Parkinson’s Disease by Asako Yoritaka, Tetsuo Hayashi, Keiko Fusegi, Rie Inami, Nobutaka Hattori

“…This prospective study aimed at determining the underlying pathophysiology using detailed clinical and psychological assessments. …”
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Impact of Incretin-Based Therapies on Adipokines and Adiponectin by Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. …”
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Heat Stroke in the Era of Global Warming: A Call for Urgent Action by Ayesha Khan, Manahil Mubeen

“…This article reviews the pathophysiology, effects, treatment, and preventive strategies of HS management. …”
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players. …”
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Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose by Jorge Rico-Fontalvo, José Correa-Guerrero, María Cristina Martínez-Ávila, Rodrigo Daza-Arnedo, Tomás Rodriguez-Yanez, Amilkar Almanza-Hurtado, José Cabrales, Carmen Julia Mendoza-Paternina, Alvaro Frías-Salazar, Julio Morales-Fernández

“…The current review discusses the available evidence related to the RHF phenomenon, including definition, epidemiology, risk factors, pathophysiology, pharmacokinetic variability, and considerations for optimizing the dosage of antibiotics in critically ill patients.…”
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Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT by Luisa Müller, Venkata A. S. Dabbiru, Lucy Rutten, Rinke Bos, Roland Zahn, Stefan Handtke, Thomas Thiele, Marta Palicio, Olga Esteban, Marta Broto, Tom Paul Gordon, Andreas Greinacher, Jing Jing Wang, Linda Schönborn

“…Therefore, these rAbs offer an attractive new option to study VITT pathophysiology.…”
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Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus by Stephen A. Myers, Alex Nield, Mark Myers

“…This previously unexplored concept would raise a whole new area of research into the pathophysiology of insulin resistance and introduce a new class of drug target with utility for diabetes pharmacotherapy.…”
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