Genetic Cholestasis: Lessons from the Molecular Physiology of Bile Formation by Peter LM Jansen, Michael Müller

“…PFIC types 1 and 2 occur due to mutations in loci at chromosome 18 and chromosome 2, respectively. The pathophysiology of PFIC type 1 is not well understood. …”
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Scorpion Venom and the Inflammatory Response by Vera L. Petricevich

“…The clinical signs and symptoms observed in humans and experimental animals are related with an excessive systemic host inflammatory response to stings and stings, respectively. Although the pathophysiology of envenomation is complex and not yet fully understood, venom and immune responses are known to trigger the release of inflammatory mediators that are largely mediated by cytokines. …”
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Florid Proliferation of Hyalinized Vessels in a Spermatic Cord STAT6 Positive Solitary Fibrous Tumor and Its Potential Clinical Implications by Christopher P. Marquez, Haiyan Zhang, Jason Goodrum, J. Nicholas Sreshta, Marjan Afrouzian

“…We also summarize our current understanding of the structural and molecular features that make up SFTs and discuss how these features may help us better understand the pathophysiology of pluripotent mesenchymal stem cell differentiation.…”
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The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies by Hessam Yaghmaei, Amirhossein Bahanesteh, Masood Soltanipur, Sobhan Takaloo, Mahdi Rezaei, Seyed Davar Siadat

“…Gut microbiota (GM) dysbiosis seems to be an influential factor in the pathophysiology of NAFLD because changes in GM lead to fundamental changes in host metabolism. …”
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Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology by Stefano Lello, Andrea Cavani

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Postpartum Hemorrhage by Michelle J. Wang, Yinka Oyelese, Yang Pan

“…This article reviews the impact of obstetric hemorrhage, the controversy regarding definitions, diagnosis, epidemiology, pathophysiology, and management of obstetric hemorrhage.…”
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Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia by Sagger Mawri, Edward Gildeh, Namita Joseph, Bobak Rabbani, Bryan Zweig

“…We herein discuss the clinical presentation, pathophysiology, diagnosis, and management of severe hypomagnesemia and emphasize the implications of magnesium deficiency in the cardiovascular and central nervous systems. …”
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Craniomandibular Disorders and Mandibular Reference Position in Orthodontic Treatment by Farid Bourzgui, Hakima Aghoutan, Samir Diouny

“…Article classification was made by two authors, using the following structure outline: prevalence of craniomandibular disorders, its etiology and pathophysiology, occlusion and craniomandibular disorders, orthodontic treatment and CMD, and the mandibular reference position in orthodontics. …”
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The role of exogenous histamine in atopic dermatitis flare-ups by Zofia Kowalska, Joanna Narbutt

“…Histamine’s diverse physiological functions, its involvement in AD pathophysiology, and the potential implications of histamine intolerance and histamine overlay syndrome are examined. …”
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Ovarian hyperstimulation syndrome. A case report by Práxedes de Regla Rojas Quintana, Sandra Gómez Fonseca, Alejandrina Najarro Navarro

“…For years, this condition has questioned the actions of physicians due to its complex pathophysiology and devastating consequences for patients of reproductive age. …”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. …”
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Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases by Maria H. Madeira, Raquel Boia, António F. Ambrósio, Ana R. Santiago

“…However, despite the beneficial effects of caffeine consumption in human health and behaviour, the mechanisms by which it impacts the pathophysiology of neurodegenerative diseases still remain to be clarified. …”
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Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches by Antonio L. Teixeira, Mitzi M. Gonzales, Leonardo Cruz de Souza, Sara L. Weisenbach

“…Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. …”
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The Importance of Lung Innate Immunity During Health and Disease by Gusty Rizky Teguh Ryanto, Ratoe Suraya, Tatsuya Nagano

“…In this review, we discuss globally how the components of lung innate immunity are important not only for maintaining lung homeostasis but also during the pathophysiology of notable lung diseases beyond acute pulmonary infections, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis.…”
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Simulation of clinical trials of oral treprostinil in pulmonary arterial hypertension using a virtual population by Andrew E. Stine, Jignesh Parmar, Amy K. Smith, Zachary Cummins, Narasimha Rao Pillalamarri, R. Joseph Bender

“…In this study, a quantitative systems pharmacology model of pulmonary arterial hypertension pathophysiology and pharmacology was used to predict changes in pulmonary vascular resistance and six-minute walk distance in the context of oral treprostinil clinical studies. …”
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Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies by Maja-Theresa Dieterlen, Katja John, Hermann Reichenspurner, Friedrich W. Mohr, Markus J. Barten

“…Such immunological responses are involved in the pathophysiological mechanisms of cardiovascular diseases, with DCs shown to play a role in atherosclerosis, hypertension, and heart failure and most notably following heart transplantation. …”
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Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress by Phillip W. Gold, Rodrigo Machado-Vieira, Maria G. Pavlatou

“…Stress-related pathways have been directly involved in the pathophysiology and treatment of MDD. The present paper provides an overview on the stress system as a model to understand key pathophysiological paradigms in MDD. …”
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Small fiber pathology in fibromyalgia syndrome by Claudia Sommer, Nurcan Üçeyler

“…For clinical practice, it is important to note that reduced skin innervation in fibromyalgia must not be confused with small fiber neuropathy, which is a separate entity with different characteristics and pathophysiology. Further prospective research is warranted to transfer these findings in the peripheral nervous system into clinical fibromyalgia patient management.…”
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Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations by Can Cui, Jian Chen, Hao Shen, Bei Zhang

“…Induced pluripotent stem cells (iPSCs), derived from PD patients, constitute an exquisite investigative tool for elucidating the pathophysiology of the disease, assessing candidate therapeutics, and probing the potential for regenerative medicine approaches. …”
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Cardiorenal Syndromes and Sepsis by C. Chelazzi, G. Villa, A. R. De Gaudio

“…The cardiorenal syndrome is a clinical and pathophysiological entity defined as the concomitant presence of renal and cardiovascular dysfunction. …”
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