Role of Vitamin D in Cardiometabolic Diseases by Chaoxun Wang

“…This paper reviews the definition and pathophysiology of vitamin D deficiency, clinical evidence linking vitamin D and CVD risk, diabetes and its complications, and metabolic syndrome.…”
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Chronic Constipation: Current Management and Challenges by Martin Storr

“…The present supplement to The Canadian Journal of Gastroenterology provides an educational overview of the current understanding of the diagnosis, epidemiology, pathophysiology and management of chronic constipation, and summarizes current treatment options in light of current and newly available drugs.…”
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Calcium Apatite Deposition Disease: Diagnosis and Treatment by Nicholas M. Beckmann

“…This is a review of the common and uncommon presentations of CADD in the appendicular and axial skeleton as well as an updated review of pathophysiology of CADD and current treatments.…”
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Clinical and Experimental Immunomodulation 2016 by Lenin Pavón, Hugo Besedosky, Oscar Bottasso, Marco A. Velasco-Velázquez, Moisés E. Bauer

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The Effect of IL-4 Gene Polymorphisms on Cytokine Production in Patients with Chronic Periodontitis and in Healthy Controls by Jirina Bartova, Petra Borilova Linhartova, Stepan Podzimek, Tatjana Janatova, Kazi Svobodova, Antonin Fassmann, Jana Duskova, Jaromir Belacek, Lydie Izakovicova Holla

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Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…The results of this study provide new insights into the pathophysiology of adenoviral keratoconjunctivitis and a potential new approach to diagnosis and prompt treatment.Keywords: tear cytokines, adenovirus infection, keratoconjunctivitis, IL-1b, IL-6, IL-8, IL-10, IL-12, TNF-a…”
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Serum Antidiuretic Hormone Level in Nocturnal Enuretic School Children in a Tertiary Care Hospital in Bangladesh: A Cross‐Sectional Study by Jannatul Fardous, Anjuman Ara, Md. Iqbal Hossain, Asma Labony, Tanjila Afrin, Rezwana Ashraf, Reaz Uddin, Habiba Jesmin, Md. Kabir Alam, Mohammad Ashraful Amin, Anwar Hossain Khan, Zahid Hasan Khan

“…These findings contribute to a better understanding of the pathophysiology of PNE and suggest potential avenues for novel treatment strategies, emphasizing the importance of evaluating ADH levels in PNE management.…”
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The Safety and Efficacy of the Repeated PRRT with [90Y]Y/[177Lu]Lu-DOTATATE in Patients with NET by Anna Zemczak, Paweł Gut, Dariusz Pawlak, Maciej Kołodziej, Leszek Królicki, Beata Kos-Kudła, Marek Ruchała, Grzegorz Kamiński, Jolanta Kunikowska

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Parkinson's Disease and Sleep/Wake Disturbances by Todd J. Swick

“…A discussion of the clinical aspects, pathophysiology, evaluation techniques, and treatment options for the sleep disorders that are encountered with PD is presented.…”
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Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications by Luke J Janssen

“…The tools used to study ion channels in ASM are described, and the investigations of the roles of ion channels in ASM physiology (autacoid-evoked depolarization and hyperpolarization) and pathophysiology (airway hyperresponsiveness) are summarized. …”
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The Utilization of Diagnostic Musculoskeletal Ultrasound in the Evaluation for Ischiofemoral Impingement: A Perspective for Rehabilitation Providers by Robert C. Manske, Chris Wolfe, Phil Page, Michael Voight, Beth Bardowski

“…This article reviews the anatomy of the IFS, the pathophysiology of IFI, and the use of MSKUS in diagnosing IFI, equipping rehabilitation professionals with the knowledge to integrate this valuable diagnostic tool into clinical practice.…”
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The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem Cells by Tao Du, Ying-Jian Zhu

“…Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. …”
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In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders by Harry Pantazopoulos, Sabina Berretta

“…Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer’s disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. …”
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Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish by Hui Lv, Bo Liu, Yongwen Qin

“…Angiogenesis contributes to the pathophysiology of cardiovascular disease (CVD). Some cardiovascular drugs used in the treatment of CVD have an effect on the process of angiogenesis. …”
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Alzheimer’s Type Neuropathological Changes in a Patient with Depression and Anxiety: A Case Report and Literature Review of Neuropathological Correlates of Neuropsychiatric Symptom... by Sumit Das

“…The author hopes that such a case will promote more in-depth studies into the pathophysiology of neuropsychiatric manifestations in AD.…”
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Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD by Kristy A. Fisher, Heidi Kiziah, Clara L. Villalba Alvarez

“…Despite its representation throughout literature, the pathophysiology of PTSD remains incompletely understood, thus contributing to broad, variable, and at times, experimental treatment options. …”
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Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders by Shihan Zhang, Shasha Tang, Yalei Liu, Binghua Xue, Qinyuan Xie, Lingyun Zhao, Huijuan Yuan

“…This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. Strategies aimed at regulating these uremic toxins offer potential avenues for reversing and managing CKM syndrome, providing new insights for its clinical diagnosis and treatment.…”
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Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration by Zhangfu Li, Honghao Yang, Yong Hai, Yunzhong Cheng

“…For example, interleukins (IL), tumour necrosis factor-α (TNF-α), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. …”
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Current Concepts of Immunology and Diagnosis in Amniotic Fluid Embolism by Michael D. Benson

“…Current thinking about pathophysiology has shifted away from embolism toward a maternal immune response to the fetus. …”
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Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update by Shane O’Sullivan, John F. Gilmer, Carlos Medina

“…This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition.…”
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