Inhalation d'aérosols liquides ou solides chez les Primates Non Humains by Jérôme Montharu, Chrystophe Aubert, Georges Roseau, Laurent Vecellio, Antoine Guillon, Michèle de Monte

“…L'aérosolthérapie est aujourd'hui utilisée pour traiter les pathologies pulmonaires, le poumon constituant également une porte d'entrée pour les médicaments à visée systémique ou pour les vaccins. …”
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Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain by XIANG Hongchun, ZHANG Hong, LI Jing, LONG Man, LI Man, CAI Guowei

“…The "up and down" method was used to measure paw withdrawal mechanical threshold (PWMT); the hematoxylin-eosin (HE) staining was used to observe pathological characteristics of DRG tissues; immunofluorescence staining was used to detect the percentage of MCP-1 and CD68 immunopositive area in DRG tissues; Western blot method was used to detect the protein expression level of CD68, MCP-1, iNOS and IL-1β in DRG tissues, and transmission electron microscope was used to observe the ultrastructure of macrophages in DRG tissues.Results(1) PWMT: compared with the control group at the same time, PWMT in the model group decreased significantly at the 8th, 11th, 13th and 15th days (<italic>P</italic>&lt;0.05); compared with the model group at the same time, PWMT in the EA group increased significantly at the 11th, 13th and 15th days, and the differences were statistically significant (<italic>P</italic>&lt;0.05). (2) Histopathological features of DRG tissues: the inflammatory cells are nearly round in shape and blue-purple in color. …”
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Generation of human induced pluripotent stem cell lines (iPSC) from adipose-derived mesenchymal stromal cells from two patients with systemic sclerosis by Mélanie Velier, Romain Appay, Robin Arcani, Romain Desprat, Stéphanie Simoncini, Anouck Zavarro, Danièle Noel, Lenha Bendaass, Christian Jorgensen, Quentin Gomes De Pinho, Audrey Benyamine, Brigitte Granel, Aurélie Daumas, Francoise Dignat George, Florence Sabatier, Jérémy Magalon

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Fu Tu Sheng Jin Rehabilitation Formula Mitigate Airway Inflammation, Mucus Secretion and Immune Dysfunction Induced by SARS-CoV-2 Spike Protein by Wang BH, Yu KY, Zhang XN, Sun XH, Tang LL, Shi XL

“…D1, D3, D10, D10H, D10M and D10L group mice were intratracheally administered with 15 μg SARS-CoV-2 spike protein; mice in the D10H, D10M, and D10L groups were intragastrically administered FTSJRF (46, 23 and 11.5 g/kg, respectively). Observe the pathological changes in lung tissues, expression of inflammatory factors, and mucins in different groups of mice using HE and PAS staining methods, as well as ELISA and RT-qPCR. …”
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Mechanism of Qingjie Fuzheng Granules on alleviating 5-FU chemotherapy-induced intestinal mucositis in a mouse model of Colorectal Cancer by regulating Cathepsin B/NLRP3 pathway by Yuan Yingfei, Lin Jiumao, Lin Minghe, Zhao Jinyan, Chen Xuzheng, Liu Jinhong, Zhu Xiaoqin

“…After the last administration of the drug on the seventh day, the mice were fasted for 12 h, then, animal samples of mice were collected for experimental detection. The pathological morphology of jejunum tissue was observed by HE staining. …”
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Eye Collateral Channel Characteristic Analysis and Identification Model Construction of Mild Cognitive Impairment by WU Tiecheng, CAO Lei, YIN Lianhua, HE Youze, LIU Zhizhen, YANG Minguang, XU Ying, WU Jinsong

“…Comparison of TCM deficiency syndrome element scores between two groups, the scores of yin deficiency, blood deficiency, Qi deficiency, fluid deficiency, and Qi depression in the MCI group were all higher than those in the normal cognition group (<italic>P</italic>&lt;0.05). The common pathological evidence elements in the MCI group were liver, kidney, muscles and bones, spleen, heart, and meridians, and the syndrome element scores of the heart, liver, and spleen were higher than those in the normal cognition group (<italic>P</italic>&lt;0.05). …”
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Retinal status in moderate myopia and age-related macular degeneration. Management strategies by L.K. Moshetova, I.B. Alekseev, I.V. Vorobyeva, Yu.A. Nam

“…FAF identified certain pathological patterns, e.g., focal hypo- and hyperautofluorescence, hyperautofluorescent halo at the border of staphyloma, linear hypoautofluorescent bands surrounded with hyperautofluorescence, reticular pattern, patches, focal and multifocal areas of geographic atrophy.…”
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Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4 by Wang W, Li Y, Zhang C, Zhou H, Li C, Cheng R, Chen X, Pu Y, Chen Y

“…Weiwei Wang,1,&ast; Ying Li,1,&ast; Cheng Zhang,2,&ast; Haoyang Zhou,1 Chunyu Li,3 Rong Cheng,1 Xufeng Chen,1 Yanan Pu,4 Yan Chen1,5,6 1Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Long Jiang Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 3Long Jiang Intensive Care Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 4Department of Clinical Laboratory, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 5Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 6Department of Emergency Management, School of Health Policy & Management, Nanjing Medical University, Nanjing, 211166, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Chen; Yanan Pu, Email chenyandoc@njmu.edu.cn; pyn342626@njmu.edu.cnPurpose: Cardiac fibrosis, a key contributor to ventricular pathologic remodeling and heart failure, currently lacks effective therapeutic approaches.Patients and Methods: Small extracellular vesicles from young healthy human plasma (Young-sEVs) were characterized via protein marker, transmission electron microscopy, and nanoparticle tracking analysis, then applied in cellular models and mouse models of cardiac fibrosis. …”
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Hubungan Stresor Psikososial pada Kehamilan dengan Partus Prematurus by Yuli Nenti Herlina, Desmiwarti ., Edison .

“…Stresor masalah internal keluarga dan perubahan hidup lingkungan tempat tinggal adalah beberapa stresor psikososial yang terbukti berhubungan dengan  partus prematurus</p><p><strong>Kata kunci:</strong> partus prematurus, stres, stresor psikososial</p><p><strong><em> </em></strong></p><p><strong><em>Abstract</em></strong></p><p><em>Preterm labor is a pathologic state with various cases, less than 50% caused by spontaneous preterm labor which is an accelaration process of fetal–maternal hypothalamic pituitary adrenal axis that caused by physical and psychological stress during pregnancy. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…This study aimed to explore potential biomarkers associated with gemcitabine chemoresistance in pancreatic cancer by utilizing gemcitabine-resistant cell lines and pathological pancreatic cancer tissues, in conjunction with data from online databases. …”
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Construction of feature selection and efficacy prediction model for transformation therapy of locally advanced pancreatic cancer based on CT, 18F-FDG PET/CT, DNA mutation, and CA19... by Liang Qi, Xiang Li, Jiayao Ni, Yali Du, Qing Gu, Baorui Liu, Jian He, Juan Du

“…Methods We retrospectively collected data from 70 patients with locally advanced pancreatic cancer who had undergone a biopsy for pathological diagnosis. These patients had complete baseline enhanced CT images and baseline CA199 results. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Conductive alterations are related to blockage of odourant transmission to the olfactory neuroepithelium, due to sinonasal pathologies like turbinate hypertrophy or nasal polyps. …”

A meta-analysis of randomized controlled trials: evaluating the efficacy of isokinetic muscle strengthening training in improving knee osteoarthritis outcomes by Wanqin Guo, Jingyang Gao, Dawazhuoma, Xiuling Mi, Ciwang, Bianba

“…Abstract Background Knee osteoarthritis (KOA) is a prevalent degenerative joint disease. The primary pathological manifestations of KOA include articular cartilage degeneration, joint space narrowing, and osteophyte formation, leading to a spectrum of symptoms, including joint pain, stiffness, reduced mobility, diminished muscle strength, and severe disability. …”
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A study of relationship between cardiac exposure dose-volume and cardiovascular autonomic dysfunction in radiotherapy by CHEN Hongyu, SU Pengyu, LUO Wenzi, PANG Dequan, WANG Feiran

“…Inclusion criteria: ① Patients who were pathologically confirmed to have malignant tumors (lung cancer breast cancer or esophageal cancer); ② patients with radiation therapy indications as recommended by the guidelines; ③ patients with an ECOG score of 0-1; ④ patients with no significant abnormalities in electrocardiogram and echocardiography results. …”
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Correlation of the Changes of Gray Matter Volume with Aβ Deposition and Learning and Memory Abilities in APP/PS1 Mice at Different Periods by Yuhao ZHANG, Hao JIN, Xiufeng ZHANG, Shengxiang LIANG, Weilin LIU, Jing TAO, Lidian CHEN

“…Objective:To analyze the correlation in the changes of cerebral gray matter volume and the ability of memory learning, and the deposition of β-amyloid protein (Aβ) in related brain regions of Alzheimer's disease (AD) double-transgenic APP/PS1 model mice, which is expected to provide reliable behavioral and imaging basis for probing the pathological features of AD animal models.Methods:A total of two groups mice were included in this study, including the wild type (WT) group and the APP/PS1 group, with 36 mice in each group. …”
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Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis by Mathilde Sollier, Marine Halbron, Jean Donadieu, Ahmed Idbaih, Fleur Cohen Aubart, Corinne Vigouroux, Martine Auclair, Olivier Bourron, Marie Bastin, Géraldine Béra, Philippe Touraine, Jacques Young, Héléna Mosbah, Agnès Hartemann, Fabrizio Andreelli, Chloé Amouyal

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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…Structural changes in rat lung tissue were evaluated by observing stained pathological sections. Western blot (WB) was used to detect fibrosis-related proteins type I collagen (Col-I), α-smooth muscle actin (α-SMA), phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) in lung tissues. …”
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Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…Additionally, Kaplan-Meier survival analysis was conducted to evaluate the relationship among IFFO1 promoter methylation level, expression level, and the prognosis of PAAD. Pathological sections of cancer tissues and corresponding adjacent tissues from 27 PAAD patients were obtained from Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. …”
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Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…Our findings offer valuable reference points for clinicians to distinguish between healthy and pathological gait patterns, facilitating early detection and intervention for gait-related disorders. …”
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Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…B-blockers (or b-adrenergic antagonists) are a group of drugs widely used in the treatment of cardiovascular diseases, namely arterial hypertension, cardiac arrhythmias, and angina pectoris as well as other types of pathologies such as anxiety or glaucoma. Part of the beneficial cardiovascular effects shown by this group of compounds has already been associated with the antioxidant properties that some of them seem to possess. …”
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