Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway by Wang J, Jiang Y, Yuan Y, Ma X, Li T, Lv Y, Zhang J, Chen L, Zhou J, Meng Y, Zhang B, Dong X, Ma L

“…The levels of miR-122-5p, inflammation indices, and organ damage were assessed using PCR, ELISA, and pathological identification techniques. Immunohistochemistry and Western blotting methods were employed to investigate the activation of inflammatory pathways. …”
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Clinical, neurological, laboratory and neuropsychological features of the course of cerebrovascular diseases in patients infected with SARS-CoV-2 by V.V. Marshtupa, T.I. Nasonova

“…The rapid global spread of the COVID-19 virus has caused an unprecedented pandemic, in the conditions of which a significant number of pathological consequences of this disease have appeared. …”
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Conclusion SBR significantly reduced clinical symptoms, joint pathological damage, and expression inflammatory cytokine expression in CIA mice. …”
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Dexmedetomidine pretreatment enhances protective effect efficacy of pericytes agaist acute lung injury in septic mice by LUO Xi, ZHANG Zisen, YANG Ao

“…Both PC cell treatment effectively alleviated the pulmonary vascular endothelial leakage， reduced Evans blue content per unit tissue， improved lung pathological structure， lung function and inflammatory responses， and significantly improved the survival rates in the PC group and the Dex-PC group （P<0.05）. …”
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Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3 by Hui Shang, Jinjin Shi, Jun Zhu, Yunfeng Guo, Xiaoyan Wang

“…Hematoxylin-eosin (H&E) staining was applied to evaluate the pathological changes in cardiac tissues. 2,3,5-triphenyltetrazolium chloride (TTC) staining was used to measure the area of myocardial infarction (MI). …”
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The association of travel distance and other patient characteristics with breast cancer stage at diagnosis and treatment completion at a rural Rwandan cancer facility by Kayleigh Bhangdia, Abirami Natarajan, Niclas Rudolfson, Stéphane Verguet, Marcia C. Castro, Jean-Marie Vianney Dusengimana, Cyprien Shyirambere, Lauren E. Schleimer, Lawrence N. Shulman, Aline Umwizerwa, Catherine Kigonya, John Butonzi, Emily MacDuffie, Temidayo Fadelu, Daniel S. O’Neil, Cam Nguyen, Tharcisse Mpunga, Nancy L. Keating, Lydia E. Pace

“…Methods We conducted a retrospective cohort study using medical record data from BCCOE patients with pathologically-confirmed breast cancer from 2012–2016. …”
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RETRACTED ARTICLE: NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway by Ke Nie, Zhong-Jiang He, Ling-Jun Kong

“…In addition, we also studied the relationship between NR3C2 expression and prognosis, pathological parameters. The relative role of NR3C2 were further predicted through bioinformatics methods and receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of NR3C2 in colon cancer. …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Further studies may be required to evaluate these findings in pathological conditions.…”
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Symptoms of dwarf elm (Ulmus pumila L.) health condition in the Left-bank Ukraine by Valentyna L. Meshkova, Olena A. Kuznetsova, Volodymyr P. Turenko

“…We assumed that some symptoms may be associated with specific types of pathologies or indicate the latent development of the disease, which is difficult to diagnose visually. …”
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Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection by Aya Ishizaka, Azumi Tamura, Michiko Koga, Taketoshi Mizutani, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Atsuhiro Yasuhara, Shinya Yamamoto, Hiroyuki Nagai, Eisuke Adachi, Yutaka Suzuki, Yoshihiro Kawaoka, Hiroshi Yotsuyanagi

“…SARS-CoV-2 infection, which follows a transient pathological course from disease onset to cure, may provide a reliable model to investigate these interactions in the gut environment. …”
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A Risk Management Approach to Global Pandemics of Infectious Disease and Anti-Microbial Resistance by Annie Sparrow, Meghan Smith-Torino, Samuel M. Shamamba, Bisimwa Chirakarhula, Maranatha A. Lwaboshi, Christine Stabell Benn, Konstantin Chumakov

“…While antimicrobial resistance is predictable, the escalating pandemic is the consequence of our reliance on antibiotics and commitment to a biomedical model that now borders on pathological. Our analysis reveals the international indenture to the biomedical model as the basis of disease control is the root driver of AMR and vaccine-derived polio. …”
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Investigating Brain Structure and Functional Alterations in the Transition from Acute to Chronic Neck Pain: A Resting-State fMRI Study by Gao Z, Cui MJ, Wang HJ, Zhang J, Xu C, Ji LX

“…Zhen Gao,1,&ast; Meng-Jie Cui,2,&ast; Hai-Jun Wang,2 Jing Zhang,3 Cheng Xu,4 Lai-Xi Ji2 1Experimental Management Center, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, 030024, People’s Republic of China; 2Second Clinical Medical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, 030024, People’s Republic of China; 3Acupuncture and Moxibustion Department II, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, 030024, People’s Republic of China; 4Radiology Department, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lai-Xi Ji, Second Clinical Medical College, Shanxi University of Traditional Chinese Medicine, Jinci Road Section 1, No. 89, Taiyuan, Shanxi, 030024, People’s Republic of China, Email jlx@sxtcm.edu.cnPurpose: The objective of this research is to delve into the central pathological mechanisms involved in the transformation from acute to chronic pain.Patients and Methods: This study enrolled 86 individuals with acute neck pain and 89 with chronic neck pain. …”
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Gastrointestinal parasites in buffalo calves in a farming context in Colon county, Zulia state, Venezuela by María Rodríguez, David Uzcátegui, Andrea González, Steward Fernández, Alfredo Sánchez

“…Buffaloes have been considered rustic and resistant to many pathologies. However, they are susceptible to parasitic infections. …”
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Identification and Immunological Characterization of Cuproptosis Related Genes in Preeclampsia Using Bioinformatics Analysis and Machine Learning by Tiantian Yu, Guiying Wang, Xia Xu, Jianying Yan

“…We successfully identified five key DECREGs and two pathological clusters in PE, each with distinct immune profiles and biological characteristics. …”
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A comprehensive analysis of erectile dysfunction prevalence and the impact of prostate conditions on ED among US adults: evidence from NHANES 2001-2004 by Yuhao Zhang, Nan Zang, Yingyue Xiang, Fanlu Lin, Xue Liu, Jing Zhang, Jing Zhang

“…While previous research suggests a potential link between ED and prostate pathologies, the association between benign prostatic hyperplasia (BPH), prostatitis, prostatic cancer (PCa), and ED remains to be elucidated.MethodsData from participants (40-80 years, n=2225) were extracted from the NHANES 2001-2004 for this observational study. …”
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The immune landscape of fetal chorionic villous tissue in term placenta by Brianna M. Doratt, Heather E. True, Heather E. True, Suhas Sureshchandra, Suhas Sureshchandra, Qi Qiao, Qi Qiao, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi

“…We report a decline in HBC abundance accompanied by an increase in infiltrating maternal macrophages, which aligns with reports of heightened chorionic villous inflammatory pathologies with pregravid obesity. Finally, given the shared fetal yolk-sac origin of HBCs and microglia, we leveraged an in vitro model of umbilical cord blood-derived microglia to investigate the impact of pregravid obesity on fetal neurodevelopment. …”
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The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation by Ke Yuan, Chunyou Lai, Lingling Wei, Tianhang Feng, Qinyan Yang, Tianying Zhang, Tao Lan, Yutong Yao, Guangming Xiang, Xiaolun Huang

“…Paraffin section staining, immunofluorescent staining, RT-qPCR (quantitative reverse transcription polymerase chain reaction), and Western blot were used to evaluate hepatic pathological changes and physiology function. Result. …”
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Elucidation of the mechanism of berberine against gastric mucosa injury in a rat model with chronic atrophic gastritis based on a combined strategy of multi-omics and molecular bio... by Lisheng Chen, Lisheng Chen, Xin Wang, Xin Wang, Jianyu Li, Lijuan Zhang, Wenbin Wu, Shizhang Wei, Wenjun Zou, Yanling Zhao, Yanling Zhao

“…HE and AB-PAS staining were employed to assess pathological damage in gastric tissue. The underlying molecular mechanism of BBR in CAG treatment was explored via the integration of network pharmacology, transcriptomics, widely targeted metabolomics and intestinal flora analysis. …”
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Development of SacB-based counterselection for efficient allelic exchange in Fusobacterium nucleatum by Peng Zhou, Bibek G C, Bo Hu, Chenggang Wu

“…Our molecular comprehension of its role in oral biofilm formation and its interactions with the host under various pathological circumstances has seen considerable advancements in recent years, primarily due to the development of various genetic tools for DNA manipulation in this bacterium. …”
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Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study by Yanhong Wang, Xixiang Cao, Baodong Shan, Song Chen, Shengnan Li, Sujuan Fei, Xunlei Pang

“…All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation. …”
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