Serum-derived small extracellular vesicles as biomarkers for predicting pregnancy and delivery on assisted reproductive technology in patients with endometriosis by Ayako Muraoka, Akira Yokoi, Akira Yokoi, Akira Yokoi, Kosuke Yoshida, Kosuke Yoshida, Masami Kitagawa, Bayasula, Mayuko Murakami, Natsuki Miyake, Reina Sonehara, Tomoko Nakamura, Satoko Osuka, Hiroaki Kajiyama

“…Although no predictors were found from miRNAs in serum EVs without endometriosis, miRNAs in serum EVs of patients with endometriosis could provide novel noninvasive biomarkers to predict pregnancy and have potential clinical applicability in ART.DiscussionFurther studies are required to examine the functional importance of these miRNAs to elucidate the pathological mechanisms of endometriosis and pregnancy.…”
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Serum albumin-carcinoembryonic antigen ratio as an effective clinical tool for predicting recurrence and overall survival in patients with rectal cancer by Hailun Xie, Hailun Xie, Lishuang Wei, Shuangyi Tang, Jialiang Gan, Jialiang Gan

“…ACR can serve as an effective auxiliary tool for pathological staging, especially in patients with stage III–IV disease. …”
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Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model by Xing Tu, Zixing Zou, Jiahui Li, Simiao Zeng, Zhengchao Luo, Gen Li, Yuanxu Gao, Kang Zhang, Jing Ni

“…An acute ocular hypertension model was used to simulate pathological ocular hypertension in vivo. We employed a series of AI methods, including large language and graph neural network models, to identify the target compounds of RIPK3. …”
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Clinical assessment of urinary prostate cancer antigen 3 in Chinese population: a large-scale, prospective and multicenter study by Xuan Shu, Jiaming Wang, Wen Cai, Shen Lin, Jiangfeng Li, Xueyou Ma, Yufan Ying, Yat Sai Terry Wang, Xiao Wang, Hong Chen, Chunyu Jin, Ben Liu, Liping Xie, Jindan Luo

“…Abstract Background To assess the clinical utility of PCA3 in the diagnostic accuracy, the correlation between PCA3 and biopsy or pathological characteristics and the performance of PCA3 to reduce the unnecessary biopsies in Chinese population. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Cox regression analysis determined that the pathological T stage, tumor stage, and RiskScore could serve as independent prognostic indicators. …”
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Optimization of treatment and prevention of recurrences of bacterial vaginosis in postmenopausal women by S.O. Ostafiichuk, N.V. Drogomyretska, O.M. Kusa, O.V. Neiko, I.V. Levitsky, N.M. Kinash

“…In the women of the first group, the risk of recurrence of the laboratory criteria of BV increases after 3 months: an increase in the pH of the vaginal contents by 1.2 times (p<0.05), the appearance of a positive aminotest in 38.1% of patients, the presence of Gardnerella vaginalis in 26.2% women with a pathological number of 104-105 CFU/ml, regression of the pool of lactobacilli with worsening of the situation and the appearance of clinical manifestations of the disease after 6 months. …”
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Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme by A. J. McCarthy, S. M. O’Reilly, J. Shanley, R. Geraghty, E. J. Ryan, G. Cullen, K. Sheahan

“…Our aim was to characterize the clinicopathological features of a series of SSL/Ps & TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps & TSAs. …”
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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

“…BackgroundNeuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing a significant role. …”
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Application-based remote interstage home monitoring for infants with shunt- or duct-dependent pulmonary perfusion by Lisa-Maria Rosenthal, Lisa-Maria Rosenthal, Lisa-Maria Rosenthal, Friederike Danne, Sophie de Belsunce, Lisa Spath, Chiara-Aiyleen Badur, Joachim Photiadis, Felix Berger, Felix Berger, Katharina Schmitt, Katharina Schmitt, Katharina Schmitt

“…A median of 353 (IQR 351–743) data entries were sent per patient during IHM of which 0.8% (IQR 0.3–1.9) were pathological. Readmissions (63%) and interventions (57%) were common, mainly due to cyanosis and infections. …”
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Multifocality and Detectability of Prostate Cancer with 3-Tesla Multiparametric Magnetic Resonance Imaging: Correlation with Radical Prostatectomy Mapping Histopathology by Serdar Karadağ, Deniz Noyan Özlü, Ahmet Hacıislamoğlu, Ömer Yıldız, Halil Fırat Baytekin, Mithat Ekşi, Hakan Polat, Alper Bitkin, Ali İhsan Taşçı

“…The reader was blinded to the pathological outcomes of any biopsy specimen. Lesions with a PIRADS score ≥3 were considered positive and included in the study. …”
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Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion by Maria Elisa Amodeo, Annalisa Deodati, Stefania Pedicelli, Giulia Mirra, Valentina Pampanini, Stefano Cianfarani

“…Conclusions: Our findings indicate that the prevalence of pathological brain lesions in boys with CPP is considerably lower than previously reported, thus making the diagnosis less alarming. …”
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Comparison of Transcutaneous Electric Nerve Stimulation (TENS) and Microcurrent Nerve Stimulation (MENS) in the Management of Masticatory Muscle Pain: A Comparative Study by B. Saranya, Junaid Ahmed, Nandita Shenoy, Ravikiran Ongole, Nanditha Sujir, Srikant Natarajan

“…Temporomandibular disorders (TMDs) are a heterogeneous group of pathologies affecting the temporomandibular joint (TMJ), the jaw muscles, or both. …”
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Clinical analysis of 1,038 cases of odontogenic jawbone cysts by Chongli Du, Zeyu Wang, Duoduo Lan, Ruikun Zhu, Dong Wang, Hanying Wang, Chengao Wan, Tingyi Gao, Rui Han, Liang Liu, Kai Zhang

“…Methods Data from 1,038 patients with OJCs were collected, and relevant information, such as sex, age, clinical symptoms and signs, imaging data, number of lesions, lesion location, pathological diagnosis, clinical treatment and prognosis, was statistically analysed. …”
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Prediction models used in the progression of chronic kidney disease: A scoping review. by David K E Lim, James H Boyd, Elizabeth Thomas, Aron Chakera, Sawitchaya Tippaya, Ashley Irish, Justin Manuel, Kim Betts, Suzanne Robinson

“…<h4>Objective</h4>To provide a review of prediction models that have been used to measure clinical or pathological progression of chronic kidney disease (CKD).…”
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Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet by Ayman Mohammed El-Anany, Rehab Farouk M. Ali

“…The administration of a HFD induced marked pathological changes in the liver and kidneys of the rats. …”
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Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae Sargassum ilicifolium (Turner) C. Agardh: Regulation of cytokine cascade by Ramamoorthi Lavanya, Jeyabalan Srikanth, Sankar Seethalakshmi, Begum M. Yasmin, Duraipandian Chamundeeswari, Sekar Mahendran, Wong Ling Shing, Subramaniyan Vetriselvan

“…This step was followed by investigations on clinical signs and gross pathological alterations seen. A complete Freund’s adjuvant-induced arthritis was used to test the in vivo activity in female Sprague–Dawley rats, which were divided into five groups: (1) normal control, (2) arthritic control, (3) methotrexate treatment (0.1 mg/kg), (4) crude sulfated polysaccharide (CSP) (5 mg/kg), and (5) CSP (10 mg/kg). …”
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Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway by Shan Xiao, Ye Yang, Yue-Tong Liu, Jun Zhu

“…Electron microscopy and HE staining were used to observe the ultrastructure and pathological changes. Results. Liraglutide treatment in DN rats decreased blood glucose, 24-hour urine microalbumin, TC, TG, LDL-C, UA, Cr, UREA, ALT, and AST levels and increased the level of HDL-C (P<0.05). …”
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Polymorphic variants of the dopamine receptor gene <i>DRD2</i> (rs6277, rs1800497) in adolescents with problematic video game use by S. Yu. Tereshchenko, K. V. Afonicheva, I. V. Marchenko, M. V. Shubina, M. V. Smolnikova

“…A sampling of 407 adolescents aged 14.1±1.8 years was tested, of which 56 (13.8 %) were identified as having problems with the pathological use of video games use based on the GASA scale results. …”
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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord by Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhang

“…Glial cells play crucial roles in regulating physiological and pathological functions, including sensation, the response to infection and acute injury, and chronic neurodegenerative disorders. …”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…These findings underscore the critical pathological role of S100A8/A9 in TBI and emphasize the need for further exploration of S100A8/A9 inhibitor Paquinimod as a potential therapeutic strategy for TBI.…”
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