Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites by O. B. Shevelev, M. P. Moshkin

“…Deviations in brain metabolism are the result of longterm pathological processes, which finally are manifested as symptoms of Parkinson’s or Alzheimer’s diseases or multiple sclerosis and other neuropathologies, as for example diabetic neuropathy. …”
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Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning by Jianhui Chen, Qun Li, Xiaofang Liu, Fang Lin, Yaling Jing, Jiayan Yang, Lianfang Zhao

“…Epidemiologic data have suggested the correlation between EMs and recurrent pregnancy loss (RPL), but the pathological mechanism is unclear. This study aims to investigate the potential biomarkers and immune infiltration in EMs and RPL, providing a basis for early detection and treatment of the two diseases.MethodsTwo RPL and six EMs transcriptomic datasets from the Gene Expression Omnibus (GEO) database were used for differential analysis via limma package, followed by weighted gene co-expression network analysis (WGCNA) for key modules screening. …”
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Comparison of the Diagnostic Performance of Five Clinical Questionnaires for Chronic Obstructive Pulmonary Disease by Alirio R. Bastidas, Eduardo Tuta-Quintero, José S. Arias, Diana Cufiño, Diana Moya, Daniel Martin, Faure Rodríguez, Carolina Aponte-Murcia, Doris M. Pumarejo, Maria A. Bejarano, Geraldine Ospina, Lina M. Morales, Adriana M. Portella, Maria D. Barragán, Daniela A. Álvarez, José M. Hernández

“…Chronic obstructive pulmonary disease (COPD) remains one of the most prevalent pathologies in the world and is among the leading causes of mortality and morbidity, partially due to underdiagnosis. …”
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Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, resp... by Fei Wang, Yongjiu Wang, Bin Xiong, Zhenlin Yang, Jingfen Wang, Yumin Yao, Lixiang Yu, Qinye Fu, Liang Li, Qiang Zhang, Chao Zheng, Shuya Huang, Liyuan Liu, Chun Liu, Huaibo Sun, Beibei Mao, Dong-Xu Liu, Zhigang Yu

“…The primary endpoint was the total pathological complete response (tpCR; ypT0/isN0) rate. …”
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Features of the functioning of the hypothalamic-pituitary-thyroid axis in mice with Lewis carcinoma on the background of induced hyperthyroidism by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, I. V. Neskubina, E. I. Surikova, A. I. Shikhlyarova, L. K. Trepitaki, M. A. Gusareva, I. A. Udalenkova, E. O. Vasilieva, N. D. Cheryarina, V. V. Pozdnyakova

“…Sex differences in the GGT response indicate different mechanisms that implement pathological processes.…”
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Comparison of Phase Estimation Methods for Quantitative Susceptibility Mapping Using a Rotating-Tube Phantom by Kathryn E. Keenan, Ben P. Berman, Slávka Rýger, Stephen E. Russek, Wen-Tung Wang, John A. Butman, Dzung L. Pham, Joseph Dagher

“…Quantitative Susceptibility Mapping (QSM) is an MRI tool with the potential to reveal pathological changes from magnetic susceptibility measurements. …”
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Chronic fatigue and headache in post-COVID-19 syndrome: a radiological and clinical evaluation by Gonçalo G. Almeida, Gonçalo G. Almeida, Saide Alkan, Saide Alkan, Robert Hoepner, André Euler, André Euler, Lara Diem, Franca Wagner

“…Similarly, no significant correlation was found when considering numbers of pathological brain lesions (fatigue: p = 0.557; headaches: p = 0.820).ConclusionWhile T2-hyperintense lesions are common in patients with post-COVID-19 syndrome, their presence does not correlate significantly with symptoms of fatigue or headaches. …”
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Selection and Engineering of Novel Brighter Bioluminescent Reporter Gene and Color- Tuning Luciferase for pH-Sensing in Mammalian Cells by Vanessa R. Bevilaqua, Gabriel F. Pelentir, Moema A. Hausen, Eliana A. R. Duek, Vadim R. Viviani

“…Firefly luciferases have been extensively used for bioanalytical applications, including their use as bioluminescent reporters, biosensors, and for bioimaging biological and pathological processes. Due to their intrinsic pH- sensitivity, in recent years we have demonstrated that firefly luciferases can also be harnessed as color- tuning sensors of intracellular pH. …”
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Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells by Xiaoming Kang, Xiaoming Kang, Lu Ma, Lu Ma, Lu Ma, Jie Wen, Jie Wen, Wei Gong, Wei Gong, Xianlin Liu, Xianlin Liu, Yihan Hu, Yihan Hu, Zhili Feng, Zhili Feng, Qiancheng Jing, Qiancheng Jing, Yuexiang Cai, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng, Yong Feng, Yong Feng, Yong Feng, Yong Feng

“…Our study explored the pathological effects of the TMEM43 mutation and its causal relationship with ANSD using a patient-derived iPSC-based GLSs model, providing a foundation for future mechanistic studies and potential drug screening efforts.…”
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Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice by Yunsheng Liu, Lan Cao, Xiaoxu Zhang, Yan Liang, Yuxia Xu, Cuiqing Zhu

“…Exposure to chronic psychiatric stress has been linked to Alzheimer’s disease-related tau hyperphosphorylation and abnormalities in glutamate neurotransmission. However, the pathological relationship between glutamatergic dysfunction and tau phosphorylation in the cerebral cortex under chronic psychiatric stress is not fully understood. …”
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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…In addition, the study explored the correlation between PAQR11 expression and drug sensitivity, alongside its molecular and pathological characteristics in various tumors. Results: Our findings demonstrate elevated PAQR11 expression levels across multiple cancer types, which significantly correlate with patient prognostic outcomes. …”
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When is synthetic sufficient? Ethical considerations and alternatives in simulation-based ultrasound education by Andrea J. Doyle, Claire M. Condron

“…Moreover, synthetic models can simulate specific pathologies, enabling targeted learning that may be difficult with animal tissue. …”
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Predicting the risk of bone metastases in patients with newly diagnosed prostate cancer - Development and validation of a nomogram model. by Wei Xu, Guoyu Zhu, Xiaoxiang Wang, Xuebing Yan, Fujun Wang, Shanyi Li, Wenji Li

“…<h4>Methods</h4>We retrospectively collected and analyzed the clinical data of patients with pathologic diagnosis of PCa from January 1, 2013 to December 31, 2022 in two hospitals in Yangzhou, China. …”
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Association of whole grain food consumption with lung cancer risk: a prospective cohort study by Kanran Wang, Junhan Zhao, Dingyi Yang, Mao Sun, Yongzhong Wu, Wei Zhou

“…All incident lung cancer cases were pathologically verified. Hazard ratios and 95% confidence intervals for lung cancer risk associated with whole grain food consumption were estimated by Cox proportional hazards regression. …”
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Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis by Yanjie Guo, Weini Wu, Haoyu Chen, Xueqi Wang, Yi Zhang, Shuaipeng Li, Xueyi Yang

“…As a result of this shared origin, corneal epithelial cells may exhibit the same characteristics as the skin epidermis in pathological situations, while keratinocytes are ideal seed cells for tissue-engineered corneas. …”
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Assessment of Zinc Alpha-2 Glycoprotein Level in Gestational Diabetes Woman in Respect to Glycemic Status with and without Treatment by Bara Nahdh Saleem, Manal Khalid Abdulridha, Hind Abdalkhaliq Showman, Manal Sabbar

“… Background: Gestational diabetes is a pathological condition that manifests between the 2nd and 3rd trimesters of pregnancy. …”
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Total neoadjuvant chemotherapy according to the FOLFIRINOX regimen for locally advanced adenocarcinoma of the stomach and cardioesophageal junction: interim results by M. V. Sedova, M. A. Batov, A. A. Kolomeytseva, V. M. Khomyakov, N. N. Volchenko, A. A. Fedenko

“…There was no correlation between pathological complete response and survival rates.Conclusion. …”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…This population showed a moderate pain intensity at baseline, important deterioration of QoL and pathological anxiety/fear related to pain. Fifty percent of them presented restless leg syndrome, 60% moderate/severe insomnia, and 62.5% sleep apnea. …”
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Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…The visualization zones of the pathological process in the brain in case of toxic damage are mainly basal ganglia and/or thalamus and dentate nucleus, cortical zone of grey matter, periventricular zone of white matter, corticospinal tract and corpus callosum; asymmetric white matter damage as a sign of demyelination; parietal-occipital subcortical vasogenic edema and lesions of the central pons are characteristic. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Behavioral assessments included neurological severity scores (NSS), social interaction test (SI), tail suspension test (TST), and forced swimming test (FST). Pathological changes were evaluated through immunofluorescence and local field potential (LFP) recordings at various time points post-injury. …”
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