Screening Southeast Asian medicinal plants: Clausena lansium, Leea indica, Strobilanthes crispa, Vitex trifolia for anti-platelet aggregation and blood coagulation effects by Sogand Zareisedehizadeh, Fu-Xun Heng, Chay-Hoon Tan, Paul Chi-Lui Ho, Hwee-Ling Koh

“…Leea indica demonstrated remarkable antiplatelet and anticoagulant activities, highlighting its potential in preventing pathological thrombus formation and related cardiovascular disorders.…”
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Comparison of Morphological and Functional MRI Assessments of Periprostatic Fat for Predicting Prostate Cancer Aggressiveness by David Freire Maia Vieira, Cecília Vidal de Souza Torres, André de Freitas Secaf, Matheus de Moraes Palma, Gabriel de Lion Gouvea, Jorge Elias Júnior, Rodolfo Borges Reis, Valdair Muglia

“…Clinical and demographic data collected included PSA, PSA density (dPSA), ISUP grade, clinical and pathological staging, and treatment details. MRI-derived parameters were assessed by an experienced radiologist, who measured subcutaneous and periprostatic fat thickness, and calculated ADC values from ROI plots in periprostatic fat. …”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…We also conducted in vitro functional assays to assess TUBA1B’s functional role in tumor cells, allowing for a detailed examination of its relationship with cancer prognosis and immune modulation.Results: Our findings indicate that TUBA1B expression is dysregulated across multiple cancers, correlating strongly with poor survival outcomes and advanced pathological stages. Functional enrichment analyses further revealed that TUBA1B regulates key cell cycle processes, driving tumor proliferation, migration, and invasion. …”
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Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

“…Similarly, hypoxia promoted fibroblastic morphological changes in HK-2 cells and enhanced NGAL, COL10A1, Vimentin, and α-SMA expression, but reduced E-cadherin expression in HK-2 cells. These pathological changes were significantly mitigated in COL10A1-silenced renal tissues and HK-2 cells. …”
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Multi-omics elucidates the kidney damage caused by aquatic Cu via the gut-kidney axis in ducks by Mingcai Duan, Jinyu Liu, Zhaoxia Cai, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Tiantian Gu, Lizhi Lu

“…Results indicate that Cu exposure causes pathological damage to the kidney, with a significant increase in the levels of TNFα, IL-6, and IL-1β in both serum and renal tissue. 16S rDNA analysis revealed that the relative abundances of Candidatus_Saccharimonas and Bacteroides were significantly reduced in the Cu-induced group. …”
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Functional alignment is a feasible alignment strategy in robotic assisted total knee arthroplasty for knee osteoarthritis with extra-articular deformity – A case series by Eu Wei Cheong, Yuik Ho Jade Pei, Kunalan G.

“…Introduction: Extraarticular deformity (EAD) with knee arthritis is a complex condition involving tri-planar bone deformity with pathological malalignment and chronic soft tissue contracture or laxity in the knee joint. …”
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Cross-protection against homo and heterologous influenza viruses via intranasal administration of an HA chimeric multiepitope nanoparticle vaccine by Yongqiang Zhao, Jia Liu, Chun Peng, Shuangshuang Guo, Bo Wang, Longping Chen, Yating Wang, Haiwen Tang, Liming Liu, Qi Pan, Shiren Li, Jingyu Wang, Dongni Yang, Enqi Du

“…Compared with controls, mice immunized with CHM-f nanoparticles with or without CpG IAMA-002 showed significant reductions in weight loss, lung viral titres and pathological changes. Conclusions These results suggest that CHM-f nanoparticle with or without CpG IAMA-002 is a promising candidate as a universal influenza vaccine. …”
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Health and Environmental Impact of Hospital Wastes: Systematic Review by Hela Ghali, Asma Ben Cheikh, Sana Bhiri, Lamia Bouzgarrou, Mohamed Ben Rejeb, Imed Gargouri, Houyem Said Latiri

“…However, these methods are generally not adequate for the disposal of pathological, radioactive, laboratory, and chemotherapy wastes. …”
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Characteristics and clinical significance of immune cells in omental milky spots of patients with gastric cancer by Yasunobu Mano, Yasunobu Mano, Yuka Igarashi, Yuka Igarashi, Keisuke Komori, Keisuke Komori, Itaru Hashimoto, Itaru Hashimoto, Hayato Watanabe, Kosuke Takahashi, Kazuki Kano, Hirohito Fujikawa, Takanobu Yamada, Hidetomo Himuro, Hidetomo Himuro, Taku Kouro, Taku Kouro, Feifei Wei, Feifei Wei, Kayoko Tsuji, Kayoko Tsuji, Shun Horaguchi, Shun Horaguchi, Shun Horaguchi, Mitsuru Komahashi, Mitsuru Komahashi, Mitsuru Komahashi, Takashi Oshima, Tetsuro Sasada, Tetsuro Sasada

“…Notably, significant differences were observed between the groups in terms of macroscopic type, lymphatic invasion, venous invasion, and pathological stage (pStage). G3, which was enriched in genes related to acquired immunity, showed earlier tumor stages (macroscopic type 0, Ly0, V0, and pStage I) and a better prognosis. …”
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Inpatient and Emergency Room Ophthalmology Consultations at a Tertiary Care Center by Daniel J. Oh, Levi N. Kanu, Judy L. Chen, Ahmad A. Aref, William F. Mieler, Peter W. MacIntosh

“…A wide range of ocular pathologies may present to the ophthalmology consultant, from acute trauma to screening for systemic syndromes. …”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…IntroductionThe multi-targeted ligands (MTDL) strategy has been recognized as a promising Approach for the development of effective treatments against Alzheimer’s disease (AD), due to the presence of multiple pathological mechanisms in AD. In this study, a series of bis(7)-harmine derivatives were designed and synthesized as multifunctional drugs for the treatment of AD.MethodsThe derivatives were synthesized by chemical methods and their structure was confirmed by nuclear magnetic resonance (NMR). …”
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Up-to-Date Imaging for Parathyroid Tumor Localization in MEN1 Patients with Primary Hyperparathyroidism: When and Which Ones (A Narrative Pictorial Review) by Valentina Berti, Francesco Mungai, Paolo Lucibello, Maria Luisa Brandi, Carlo Biagini, Alessio Imperiale

“…While laboratory tests are fundamental for diagnosis, imaging is crucial for localizing pathological parathyroids to aid in precise surgical planning. …”
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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits by Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

“…Abstract Background The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. …”
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An endoscopic ultrasound-based interpretable deep learning model and nomogram for distinguishing pancreatic neuroendocrine tumors from pancreatic cancer by Nan Yi, Shuangyang Mo, Yan Zhang, Qi Jiang, Yingwei Wang, Cheng Huang, Shanyu Qin, Haixing Jiang

“…Following confirmation via pathological examination, a retrospective analysis was performed on a cohort of 266 patients, comprising 115 individuals diagnosed with PNETs and 151 with pancreatic cancer. …”
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Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

“…A rat model of POI was used to assess efficacy based on the spleen index and charcoal powder propulsion rat in the small intestine. Furthermore, pathological damage to the small intestine was analyzed using hematoxylin and eosin (HE) staining as well as immunofluorescence to evaluate ZO-1 protein expression. …”
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Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular n... by Liu Chang, Yu Hao, Xia Hongyi, Wang Ziwei, Li Bolin, Xue Hongmei, Jin Sheng, Xiao Lin, Wu Yuming, Guo Qi

“…Butyrate is generated by gut microbiota and influences numerous physiological and pathological processes in the host. …”
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TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway by Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu

“…After 24 h, the indicators related to kidney injury in blood samples were detected. The pathological changes in the kidneys were observed by hematoxylin-eosin staining, and tubular damage was scored. …”
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Study of possible intrauterine infection of goat fetus with caprine arthritis-encephalitis virus by V. Yu. Koptev, N. A. Shkil, N. Yu. Balybina, T. N. Belenkova

“…Pregnant goats with ELISAand PCR-confirmed CAE diagnosis were used in the study. Pathological material was collected from newborn goats obtained by sterile kidding, and the samples were PCR tested for the CAE causative agent. …”
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Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients by Stella Maris Ranuncolo, Eduardo Armanasco, Myriam Nuñez, Laura Yuan, Sujhrob Makhkamov, Mariana S. De Lorenzo

“…We did not find any significant association between the serum FGF21 levels, and many clinical-pathological or metabolic parameters determined at the diagnosis of the primary disease. …”
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Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study. by Md Mostafa Kamal, Kazi Fahmida Haque Shantanu, Shamiha Tabassum Teeya, Md Motiar Rahman, A K M Munzurul Hasan, Douglas P Chivers, Tanveer A Wani, Atekah Hazzaa Alshammari, Mahesh Rachamalla, Francisco Carlos da Silva Junior, Md Munnaf Hossen

“…Further, experimental studies are needed to analyze the effect of these nsSNPs on the susceptibility of pathological phenotype populations.…”
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