Paratubular basement membrane insudative lesions predict renal prognosis in patients with type 2 diabetes and biopsy-proven diabetic nephropathy. by Koki Mise, Yutaka Yamaguchi, Junichi Hoshino, Toshiharu Ueno, Akinari Sekine, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Takeshi Fujii, Shigeko Hara, Hitoshi Sugiyama, Hirofumi Makino, Jun Wada, Kenichi Ohashi, Kenmei Takaichi, Yoshifumi Ubara

“…<h4>Aims</h4>Glomerular insudative lesions are a pathological hallmark of diabetic nephropathy (DN). However, paratubular basement membrane insudative lesions (PTBMIL) have not attracted much attention, and the association between such lesions and the renal prognosis remains unclear.…”
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The mechanism of enterogenous toxin methylmalonic acid aggravating calcium-phosphorus metabolic disorder in uremic rats by regulating the Wnt/β-catenin pathway by Xing Fan, Jing Li, Yan Gao, Lin Li, Haisong Zhang, Zhaoyu Bi

“…Sham rats were injected with exogenous MMA or Salinomycin (SAL). Pathological changes in renal/colon tissues were analyzed. …”
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QSPR Analysis of Some Alzheimer’s Compounds via Topological Indices and Regression Models by Muhammad Shoaib Sardar, Khalil Hadi Hakami

“…Alzheimer’s disease (AD) is of particular importance among pathologies, and despite approved drugs for its treatment, there is no effective pharmacological therapy to stop, halt, or repair neurodegeneration. …”
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Beyond the Surface and Exploring the Microscopic Landscape: Histomorphological Findings in Appendicectomy Specimens by Radhika C. Sasturkar, Pushpalatha Karumanchi, Pranathi Mahankali

“…Conclusions: Acute appendicitis, chronic appendicitis, and granulomatous appendicitis are the most common diagnoses following pathological examination of the resected appendix. However, rare findings such as diverticulum, parasitic infestations, and tumors of the appendix were also found. …”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

“…Background: Thrombosis and endothelial injury are pathologic hallmarks of pulmonary arterial hypertension (PAH). …”
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MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB by Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li

“…These insights emphasize the necessity of targeting glycosylation modifications of GPNMB in the design of novel senolytic therapies aimed at mitigating cellular ageing and its associated pathologies.…”
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A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair by Shan An, Claudio Intini, Donagh O'Shea, James E. Dixon, Yiran Zheng, Fergal J. O'Brien

“…Articular cartilage has limited capacity for repair (or for regeneration) under pathological conditions, given its non-vascularized connective tissue structure and low cellular density. …”
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A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels by Bei Pei, Qin Sun, Yi Zhang, Ziang Wen, Wenjing Ding, Kairui Wu, Tingting Li, Xuejun Li

“…Methods A retrospective analysis was conducted, encompassing 570 cases of CAG patients admitted to the Department of Gastroenterology of the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, who underwent gastroscopy and received pathologically confirmed diagnoses between June 2018 and June 2023. …”
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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…In this review, we consider how these decisions can be supported in light of information accrued from a range of clinical studies across healthy, at‐risk and pathological study populations, where specific strains have been evaluated in the context of gastrointestinal physiology, brain function and behaviour. …”
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Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression by Mieszko Lachota, Anton Lennikov, Karl-Johan Malmberg, Radoslaw Zagozdzon

“…Kaplan-Meier, Cox, and ROC analyses demonstrated superior performance of our risk score compared to either clinical or pathologic characteristics of both cohorts. Further, we found the molecular pathways associated with cancer immunoevasion and metastasis to be enriched in the high-risk group, explaining both the lack of adequate immune surveillance despite increased infiltration of CD8+ T cells as well as the higher metastatic potential. …”
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MOG associated autoimmune encephalomyelitis with active disease dynamic in imaging examinations and minimal clinical manifestation by E. Tilindytė, I. Muliuolis, R. Samaitienė

“…MOG spectrum disorders include the following pathologies: optic neuritis, myelitis, brain or brainstem encephalitis, and acute disseminated encephalomyelitis. …”
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Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition by Linli Yao, GuangHui Zi, Miao He, Yuhong Xu, Lulu Wang, Baowei Peng

“…Abstract Asparagine endopeptidase (AEP) is ubiquitously expressed in both physiological and pathological contexts, yet its precise role and functional mechanism in breast cancer remain elusive. …”
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Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model by Fatemeh Kheradmand, Seyedeh Fatemeh Yasaman Rahimzadeh, Seyed-Alireza Esmaeili, Sajad Sahab Negah, Najmeh Kaffash Farkhad, Seyedeh Elnaz Nazari, Mehrdad Hajinejad, Mohammad Ali Khodadoust, Afsane Fadaee, Jalil Tavakol Afshari, Majid Khazaei

“…Upon sacrificing the mice, colon and spleen tissues were isolated to assess the changes in the mice’s weight, colon length, spleen weight, and colitis’ pathological symptoms. IL-10 and IL-17 levels were measured, and Treg and Th17 cell percentages were determined as well. …”
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The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer by Ross D. Dolan, Kathryn Pennel, Joshua Thompson, Molly McKenzie, Peter Alexander, Colin Richards, Douglas Black, Tanvir Abbass, Noori Maka, Josh McGovern, Antonia Roseweir, Stephen T. McSorley, Paul G. Horgan, Campbell Roxburgh, Donald C. McMillan, Joanne Edwards

“…Of these, 70.4% were over 65 years of age, 54.8% were male and 49.8% had an ASA grade of 1 or 2. Pathological examination showed that the majority of patients had a T3 (53.7%) or a T4 (34.0%) cancer and 73.0% had evidence of necrosis. …”
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Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population by Dione Aguilar, María Lourdes Garza-Rodríguez, Carolina Elizabeth Muñiz-Garza, Fernando Alcorta Nuñez, Cynthia Mayte Villarreal-Garza, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores

“…Abstract Background Hereditary predisposition to breast and ovarian cancer syndrome (HBOC) is a pathological condition with increased cancer risk, including breast (BC), ovarian cancer (OC), and others. …”
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Fipronil in sub-lethal doses leads to immuno-toxicological effects in broiler birds. by Shafia Tehseen Gul, Muhammad Zergham Tahir, Latif Ahmad, Aisha Khatoon, Muhammad Kashif Saleemi, Farid Shokry Ataya, Riaz Hussain, Bakhtawar Maqbool, Dalia Fouad, Ahrar Khan

“…So, this study was designed to evaluate the toxico-pathological effects of fipronil on the immune system of poultry birds. …”
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A longitudinal MRI study on lymph nodes histiocytosis of a xenograft cancer model. by María Jiménez-González, Sandra Plaza-García, Janire Arizeta, Silvia Bianchessi, César Trigueros, Torsten Reese

“…<h4>Conclusions</h4>The lack of metastasis as well as the pathological manifestation of the lymph node alteration in this pre-clinical model established here parallels findings in patients with sinus histiocytosis that is correlated with improved survival.…”
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Long Noncoding RNA SNHG4 Attenuates the Injury of Myocardial Infarction via Regulating miR-148b-3p/DUSP1 Axis by Sheng Wang, Zhaoyun Cheng, Xianjie Chen, Guoqing Lu, Xiliang Zhu, Gaojun Xu

“…SNHG4 overexpression also decreased infarct and fibrosis areas, relieved pathological changes, and improved heart function in MI rats. …”
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Unusual presentation of a patient with partial anomalous pulmonary venous connections without a septal defect: a case report and literature review by Pouya Ebrahimi, Mohammad Hossein Mandegar, Mehrdad Jafari Fesharaki, Negar Ghasemloo, Pedram Ramezani, Tooba Akbari, Fatemeh Naderi

“…Abstract Introduction Partial anomalous pulmonary vein connections (PAPVC) are rare congenital abnormalities in which one or more pulmonary veins drain into the right atrium. This pathological condition may present in various ways, such as chest pain and dyspnea, or it may be diagnosed incidentally. …”
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Prevalence and prognosis of malignancy in THSD7A-associated membranous nephropathy: a systematic literature review and clinical case study by Qianqian Xu, Jiayi Li, Yue Yang, Li Zhuo, Hongmei Gao, Shimin Jiang, Wenge Li

“…Subsequently, we followed patients with THSD7A-associated MN for a minimum of 3–5 years, collecting their clinical, pathological characteristics, and prognosis. Additionally, we conducted a literature review on patients with THSD7A-associated MN in conjunction with malignancy.Results We identified a total of nine articles containing comprehensive data on THSD7A-associated MN and malignancy. …”
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