THE USE OF ARTIFICIAL INTELLIGENCE IN THE THERAPEUTIC MANAGEMENT OF PAPILLARY THYROID MICROCARCINOMA: A RANDOMIZED CONTROLLED TRIAL PROTOCOL by Ramona Elena Teiu, Tudor Florin Ursuleanu, Hlescu Cristian Stefan, Roxana Grigorovici, Andreea Roxana Luca, Maria Paula Comanescu, Alina Ionela Calin, Alexandru Grigorovici

“…Materials and methods The optimization of the method will consist in the development and training of artificial intelligence models, using AI algorithms in the diagnosis of papillary thyroid cancererol by accurately identifying pathological lesions and adenopathy and generating 3D images from 2D CT images. use the transfer function for opacity and color, grayscale from DICOM images projected in a three-dimensional space. [1]; [2] We also use artificial intelligence (AI), through the Generative Adversarial Networks (GAN) technique, which has proven to be effective in representing complex data distributions [2], as we do in this study. …”
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Safety and validity of extracorporeal fenestration and in situ fenestration in patients with aortic disease involving the left subclavian artery: a prospective, single-center, rand... by Xiaojian Jia, Jingjin Wu, Caiyou Ding, Yanbo Lou

“…Abstract Background Thoracic aortic pathologies involving the aortic arch are a great challenge for vascular surgeons. …”
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A European Approach to Irritable Bowel Syndrome Management by Michel Delvaux, Jacques Frexinos

“…Most of the therapeutics proposed for the management of patients with IBS have been developed on the assumption that motility disorders of the gut are the most reliable pathological findings among these patients. Consequently, antispasmodics and motility regulatory agents have been widely used, alone or in association with intestinal adsorbents (clay-derived preparations), and laxatives or antidiarrhetic agents. …”
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Cortico-Muscular Phase Connectivity During an Isometric Knee Extension Task in People With Early Parkinson’s Disease by Nina Omejc, Tomislav Stankovski, Manca Peskar, Milos Kalc, Paolo Manganotti, Klaus Gramann, Saso Dzeroski, Uros Marusic

“…Notably, CM phase coherence exhibited distinct scalp topography and spectra characteristics compared to the EEG power spectrum, suggesting different mechanisms underlying Parkinsonian pathological beta power increase and CM phase connectivity. …”
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Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…Studies on the functional connection between SIRT and longevity, as well as its effect on pathological processes associated with aging, such as chronic inflammation, fibrosis, and neuroinflammation, have been critically analyzed.…”
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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…Histology was used to evaluate pathological changes. Indicators of inflammation and apoptosis were detected. …”
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Multiple Adenomatous Duodenal Polyposis by Zdena Zádorová, Jan Hajer, Václav Mandys

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Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy by Yatong Chen, Fei Luo, Tingji Zhang, Jian Li

“…HER2 positivity was significantly associated with tumor size, multifocality, pathological grade, tumor stage, and pelvic lymph node metastasis (P < 0.05). …”
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Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

“…After 7 days of intervention, the left cerebral cortex tissue of each group was obtained, hematoxylin-eosin (HE) staining was used to observe the pathological changes of the brain tissue, the expression level of LC3-Ⅱ/LC3-Ⅰ protein was detected by Western blot, and the tissue immunofluorescence technology was applied to detect the expression and colocalization of mitophagy-related protein BNIP3L and SQSTM1 labeled. …”
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Oligodendrocyte Injury in Multiple Sclerosis. by Mateo Përgjegji, Klei Bame, Ketrina Ceka, Jera Cenalia , Sibora Bërdica , Teona Bushati

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The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study by Muhammad Pandunugrahadi, Komang Agung Irianto, Oen Sindrawati

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Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics by Ibrahim El-Serafi, Sinclair Steele

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Developmental defects in ectodermal appendages caused by missense mutation in edaradd gene in the nfr mangrove killifish kryptolebias marmoratus by Hussein A. Saud, Paul A. O’Neill, Brian C. Ring, Tetsuhiro Kudoh

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Hormonal Implications of SARS-CoV-2: A Review of Endocrine Disruptions by Aliya Yskak, Yevgeniy Sokharev, Kuanysh Zhumalynov, Elizaveta Koneva, Natalia Afanasyeva, Dmitri Borodulin, Dmitrii Babaskin, Almabek Nugmanov, Murat Nurushev, Vadim Chashkov

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Surgical Management of Extrafollicular Variant of Adenomatoid Odontogenic Tumor in the Maxillary Posterior Region by Gerardo La Monaca, Nicola Pranno, Cira Rosaria Tiziana di Gioia, Giorgio Pompa, Iole Vozza, Maria Paola Cristalli

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The role of VNTR aggrecan gene polymorphism in the development of osteoarthritis in women by D. A. Shapovalova, A. V. Tyurin, S. S. Litvinov, E. K. Khusnutdinova, R. I. Khusainova

“…We searched for associations between the VNTR locus and OA in general and with an account of the localization of the pathological process, as well as with the presence of uCTD signs. …”
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Multiproxy analysis exploring patterns of diet and disease in dental calculus and skeletal remains from a 19th century Dutch population by Bartholdy, Bjørn Peare, Hasselstrøm, Jørgen B., Sørensen, Lambert K., Casna, Maia, Hoogland, Menno, Historisch Genootschap Beemster, Henry, Amanda G.

“…Skeletal and dental analysis was performed to explore potential relationships between pathological lesions and presence of alkaloids. Dental calculus was analysed using ultra-high-performance liquid chromatography-tandem  mass spectrometry (UHPLC-ESI-MS/MS). …”
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Lactobacillus acidophilus alleviate Salmonella enterica Serovar Typhimurium-induced murine inflammatory/oxidative responses via the p62-Keap1-Nrf2 signaling pathway and cecal micro... by Haihua Li, Xinyi Ma, Zhiyuan Shang, Xuejiao Liu, Jiayun Qiao

“…We found that the early intervention of LA alleviated the pathological injury and reversed the down-regulation of the duodenal and hepatic tight junction protein mRNA levels caused by S. …”
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Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa by Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

“…ABSTRACT Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMDNterm, facilitating the release of cytokines. …”
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Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia by Jinny Hong, Katherine Mun, Katherine Mun, Kyle C. Kern, Kyle C. Kern, Marissa Thirion, Jason D. Hinman, Jason D. Hinman

“…In this framework, blood biomarkers are divided into broad pathologic categories including inflammation, neurodegeneration, neuroaxonal injury, and vascular injury. …”
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