The Possible Role of Neutrophils in the Induction of Osteoclastogenesis by Carolyn G. J. Moonen, Teun J. de Vries, Patrick Rijkschroeff, Patrice E. Poubelle, Elena A. Nicu, Bruno G. Loos

“…We hypothesized that polymorphonuclear leukocytes (PMNs), found as the most prominent cells of inflamed periodontal tissues, could play an important role in providing signals to trigger osteoclastogenesis and thus activating pathological bone resorption in periodontitis. RANKL expression was investigated on circulatory PMNs (cPMNs) and oral PMNs (oPMNs) taken from both controls and periodontitis patients. …”
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Ocular inoculation of toad venom: toxic cataract and proteomic profiling by Danni Lyu, Danni Lyu, Shuang Ni, Shuang Ni, Jia Xu, Jia Xu, Sha Zhu, Sha Zhu, Jing-Wei Xu, Jing-Wei Xu, Yixuan Feng, Yixuan Feng, Ce Shi, Ce Shi, Wen Xu, Wen Xu

“…PurposeTo report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.MethodsA young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. …”
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A new strategy for pharmacodynamic substance screening and research on gut microbiota pathway mechanisms based on UPLC-Q-orbitrap-MS and 16S rRNA by Zhiying Yu, Tong Li, Jie Yang, Jianghua He, Weijiang Zhang, Siyuan Li, Yunpeng Qi, Yihui Yin, Ling Dong, Wenjuan Xu

“…This research systematically analyzed the active components and metabolic transformation of GQD in the colon during the pathological state of UC, as well as changes in the structure and function of the gut microbiota, clarified the mechanism of GQD and its active components in improving UC via the gut microbiota pathway.…”
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miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…Micro-RNA-149 (miR-149) mediates many physiological and pathological processes, including atherosclerosis. However, it is unclear about the roles of miR-149 in endothelial injury. …”
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Modern approaches to the therapy of computer visual syndrome by Zakharova M.A., Zh.G. Oganezova

“…However, doctors noted the growth of  pathological changes in the organs and systems of the human body, induced by work at the computer. …”
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MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway by Qiong Xiang, Hu Lin, Jia-Sheng Tao, Chuan-Jun Fu, Li-Ni Liu, Jing Deng, Xian-Hui Li

“…Abstract Background Diabetic encephalopathy (DE) is considered as one of the complications of diabetes,which is associated with cognitive impairment in the pathological process of development. Up to now, phospholipid phosphatase related 4 (Plppr4), also known as plasticity related gene 1 (PRG-1) has been revealed its important role in neuroplasticity. …”
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Genetic analysis of nucleotide sequences of neuraminidase gene of highly pathogenic avian influenza A/H5N8 virus isolates recovered in the Russian Federation in 2020 by P. B. Akshalova, N. G. Zinyakov, A. V. Andriyasov, P. D. Zhestkov, Z. B. Nikonova, S. N. Kolosov, I. A. Chvala

“…The article provides data on complete nucleotide sequences of the neuraminidase gene of highly pathogenic avian influenza virus isolates recovered in the second half of 2020 from pathological material received from four regions of the Russian Federation. …”
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Small extracellular vesicles derived from miRNA-486 overexpressed dental pulp stem cells mitigate high altitude pulmonary edema through PTEN/PI3K/AKT/eNOS pathway by Changyao Wang, Zhuang Mao, Drolma Gomchok, Xue Li, Huifang Liu, Jingyuan Shao, Hu Cao, Guanzhen Xue, Lin Lv, Junzhao Duan, Tana Wuren, Hua Wang

“…The sEVNull mitigated pathological changes in the lungs, reduced pulmonary artery pressure and lung water content, and alleviated oxidative stress and inflammatory responses in cases of HAPE. …”
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A novel approach to completely alleviate peripheral neuropathic pain in human patients: insights from preclinical data by Safa Shehab, Mohammad I. K. Hamad, Bright Starling Emerald

“…While acute pain serves as a warning signal for potential tissue damage, neuropathic pain represents a chronic pathological condition resulting from injury or disease affecting sensory pathways of the nervous system. …”
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Comprehensive Metabolomic Profiling in Adults with X-Linked Hypophosphatemia: A Case-Control Study by Luis Carlos López-Romero, José Jesús Broseta, Marta Roca-Marugán, Noemí Máñez Ramírez, Julio Hernández-Jaras

“…Metabolomic analysis, which examines metabolites as the final products of cellular processes, is a powerful tool for identifying in vivo biochemical changes, serving as biomarkers of pathological abnormalities, and revealing previously uncharted metabolic pathways. …”
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A Cause of Diarrhea in a Patient with Selective Immunoglobulin A Deficiency by M. I. Gonik, V. S. Shcherbakha, E. Yu. Yuryeva, I. M. Kartavenko, A. S. Tertychny, P. V. Pavlov, A. E. Leonovich, T. L. Lapina, V. T. Ivashkin

“…A 46-year-old woman complained of a mushy stool without pathological impurities up to 5 times a day. An outpatient colonoscopy revealed signs of terminal ileitis. …”
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Construction of oncolytic reporter influenza viral vectors and assessment of their safety following intracranial administration in rats by A. A. Pulkina, A. S. Mustafaeva, E. A. Romanovskaya-Romanko, M. A. Plotnikova, O. O. Ozhereleva, M. A. Shuklina, L. N. Kiseleva, Y. S. Alekseeva, N. S. Kurmazov, A. R. Muslimov, A.-P.S. Shurygina, M. A. Stukova

“…Intracranial administration of a high dose of the virus was safe, causing no neurological or other pathological symptoms in rats. In addition, the luminescent reporter NanoLuc was expressed at the injection site without the formation of active viral progeny. …”
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How to Translate Basic Knowledge into Clinical Application of Biologic Therapy in Spondyloarthritis by Chung-Tei Chou

“…Therefore, the dramatic clinical and pathologic response of anti-TNFα therapy in SpA is based upon the presence of increased TNFα in synovial tissues and sacroiliac joints, which perpetuates chronic inflammation. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…Mammography of patients with pathologically proven breast cancer was obtained from two centers. …”
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Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…Furthermore, cilostazol therapy lowered hippocampal levels of amyloid beta 1–42 (Aβ1-42) and p-tau protein, both of which are critical pathological indicators of neurodegenerative disorders. …”
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Minimizing skull defects in retrosigmoid approach: precision mapping of the sigmoid sinus with mastoid emissary vein canal by Artem V. Rozumenko, Mykola V. Yehorov, Vasyl V. Shust, Dmytro M. Tsiurupa, Anton M. Dubrovka, Petro M. Onishchenko, Volodymyr O. Fedirko

“…The retrosigmoid approach is a commonly used cranial approach to the cerebellopontine angle lesions, vascular and nerve pathologies. This study aims to develop a practical technique for intraoperative mapping of the sigmoid sinus using the topography of the mastoid emissary vein (MEV) canal to improve the accuracy of retrosigmoid craniotomy, and minimize postoperative adverse outcomes. …”
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ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway by Xi Zhu, Xiaogang Zhang, Xinpeng Cong, Luoning Zhu, Zhongping Ning

“…Atrial fibrillation (AF) is the more significant portion of arrhythmia in clinical practice, with inflammation and fibrosis as its central pathological mechanisms. This study aimed to investigate angiopoietin-like 4 (ANGPTL4) effects on angiotensin II- (Ang II-) induced AF and its related pathophysiological mechanisms. …”
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A data ensemble-based approach for detecting vocal disorders using replicated acoustic biomarkers from electroglottography by Lizbeth Naranjo, Carlos J. Pérez, Daniel F. Merino

“…Introduction: The relevant prevalence of voice-related pathologies underscores the need for robust computer-aided diagnostic (CAD) systems capable of supporting early detection and continuous monitoring. …”
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NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB by Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He

“…Nuclear factor E2-related factor 2 (NRF2) plays an anti-inflammatory role in several pathological processes, but its function in lipopolysaccharide- (LPS-) induced goat endometrial epithelial cells (gEECs) is still unknown. …”
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Metabolic diseases in cattle by V. A. Mischenko, A. V. Mischenko, R. V. Yashin, V. A. Yevgrafova, T. B. Nikeshina

“…Metabolic disorders often remain unnoticed and become apparent only when pronounced pathological changes occur resulting in decreased productivity and ability to reproduce resistant young animals, as well as culling of animals. …”
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