<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms by K. V. Ustyantsev, V. Yu. Vavilova, A. G. Blinov, E. V. Berezikov

“…Without treatment, acute and chronical infections frequently lead to the development of severe pathologies and even death. Emerging data on a decreasing eff iciency of some important anthelmintic compounds and the emergence of resistance to them force the search for alternative drugs. …”
Get full text

DMRIntTk: Integrating different DMR sets based on density peak clustering. by Wenjin Zhang, Wenlong Jie, Wanxin Cui, Guihua Duan, You Zou, Xiaoqing Peng

“…In addition, the overlap analysis suggests that the integrated DMR sets are quite comprehensive, and functional analyses indicate the integrated disease-related DMRs are significantly enriched in biological pathways associated with the pathological mechanisms of the diseases. A comparative analysis of the integrated DMR set versus each original DMR set further highlights the superiority of DMRIntTk, demonstrating the unique biological insights it can provide.…”
Get full text

15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity by Kan Chen, Jingjing Li, Junshan Wang, Yujing Xia, Weiqi Dai, Fan Wang, Miao Shen, Ping Cheng, Yan Zhang, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Yuanyuan Zheng, Jie Lu, Zhuoyi Fan, Yingqun Zhou, Chuanyong Guo

“…Pretreatment with 15d-PGJ2 reduced the pathological effects of ConA-induced autoimmune hepatitis and significantly reduced the levels of cytokines after injection. 15d-PGJ2 activated PPARγ, blocked the degradation of IκBα, and inhibited the translocation of NF-κB into the nucleus. …”
Get full text

Retrospective investigation of non-traumatic small intestine perforations: Our single center 7-year clinical experiences by Sebnem Cimen, Burak Ucaner, Ahmet Kamburoglu, Cilga Ecem Lamba

“…Non-traumatic small intestine perforations (NTSIP) constitute a rare cause of acute surgical pathologies and have a high mortality and morbidity if not treated in time. …”
Get full text

Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…Coenzyme Q10 (CoQ10), known for enhancing reproductive outcomes in various pathologies, is not fully understood for its effects on obesity treatment. …”
Get full text

FREQUENCY OF RH-D NEGATIVE & WEAK D IN PAKISTANI POPULATION by Muhammad Usman et al

“…Conclusion: Although frequency of weak D does not came high among our donors but is still significant enough to advocate testing of weak D in routine for all Rh –ve donors & pregnant women in order to avoid consequences of anti-D allo-immunization which can lead to serious hemato-pathological problem. …”
Get full text

The effects of the SARS-CoV-2 pandemic on self-reported interoception and mental health. by Federica Biotti, Melissa Barker, Lara Carr, Hannah Pickard, Rebecca Brewer, Jennifer Murphy

“…Evidence suggests that not only pathological anxiety, but also heightened levels of state anxiety and stress are associated with interoceptive functioning. …”
Get full text

Self-beneficial transactional social dynamics for cooperation in Shwachman-Diamond syndrome: a mixed-subject analysis using computational pragmatics by Arthur Trognon, Arthur Trognon, Arthur Trognon, Natacha Stortini, Natacha Stortini, Coralie Duman, Coralie Duman, Nami Koïdé, Ewa Skupinska, Ewa Skupinska, Hamza Altakroury, Alizée Poli, Alizée Poli, Loann Mahdar-Recorbet, Loann Mahdar-Recorbet, Blandine Beaupain, Jean Donadieu, Michel Musiol, Michel Musiol, Michel Musiol

“…Unlike behaviors classically observed in other pathologies such as autism spectrum disorders, where responses are influenced by the directness of communication, SDS behaviors were driven by personal gain, regardless of the indirectness of requests. …”
Get full text

Skin Temperature in Parkinson’s Disease Measured by Infrared Thermography by Mathias Møller Purup, Karoline Knudsen, Pall Karlsson, Astrid Juhl Terkelsen, Per Borghammer

“…Patients with Parkinson’s disease (PD) often show peripheral autonomic dysfunction and depositions of pathological alpha-synuclein aggregates in the skin. …”
Get full text

Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress by Yan Liu, Yan Liu, Feng Qi, Lun-Jian Xiang, Zhu-Jun Yi, Sheng-Wei Li

“…The target was further validated by in silico, in vivo and in vitro experiments.ResultsRut significantly alleviated liver dysfunction, pathological injury, and apoptosis and improved the survival rate of the rats subjected to LT. …”
Get full text

The Impact of Amniotic Fluid Interleukin-6, Interleukin-8, and Metalloproteinase-9 on Preterm Labor: A Narrative Review by Theodoros Karampitsakos, Despoina Mavrogianni, Nikolaos Machairiotis, Anastasios Potiris, Periklis Panagopoulos, Sofoklis Stavros, Panos Antsaklis, Peter Drakakis

“…Previous research has indicated that an inflammatory response or microbial invasion of the amniotic cavity is a pathological condition linked to preterm birth; hence, inflammatory markers such as metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), and interleukin-8 (IL-8) have been utilized to predict preterm delivery. …”
Get full text

Comparison of clinical outcomes between double arterial cannulation and single arterial cannulation in type A aortic dissection by Zhiwei Tang, Chunze Yuan, Hong Liu, Yi Ding, Jiaxi Gu, Minghui Li, Buqing Ni, Yongfeng Shao

“…In order to balance the data encompassing specific pathological traits, stabilized inverse probability weighting (IPTW) was utilized. …”
Get full text

A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review by Giustino Varrassi, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Marco Cascella, Gabriele Finco, Salvatore Sardo, Chiara Corno, Domenico Tiso, Vittorio Schweiger, Diego Maria Michele Fornasari, Antonella Paladini

“…The deep literature analysis aims to examine the potential advantages of PEA, in the context of several pathological conditions that may benefit from this molecule. …”
Get full text

CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53 by Hongqiang Gao, Ran Xie, Rong Huang, Chonglin Wang, Yue Wang, Dongdong Wang, Kaimin Liu, Conghui Yang, Qingxiong Yang, Long Chen

“…CIRBP is a cold-induced protein that plays a key role in many physiological and pathological processes, but its role in pancreatic cancer is still unclear. …”
Get full text

Rasch Model Analysis of the Psychometric Properties of the Positive Mental Health Scale in Students by Noorellah Yousefi, Alireza Pirkhaefi

“…Introduction: Mental health encompasses more than just the absence of pathological symptoms or diseases; it also includes the presence of positive mental health indicators. …”
Get full text

Results of scientific expedition to natural biotopes of the Republic of Tyva in 2019 with the purpose of infectious disease monitoring in wild bird populations by M. S. Volkov, V. N. Irza, A. V. Varkentin, S. V. Rogolyov, A. V. Andriyasov

“…Droppings (pooled samples), parts of internal organs from dead and shot birds, blood (if possible) served as biological and pathological material for testing. While sampling, species were identified using an ornithological guide. …”
Get full text

CLARITY and Light-Sheet microscopy sample preparation in application to human cerebral organoids by T. A. Shnaider, I. E. Pristyazhnyuk

“…Cerebral organoids are three-dimensional cell-culture systems that represent a unique experimental model reconstructing early events of human neurogenesis in vitro in health and various pathologies. The most commonly used approach to studying the morphological parameters of organoids is immunohistochemical analysis; therefore, the three-dimensional cytoarchitecture of organoids, such as neural networks or asymmetric internal organization, is difficult to reconstruct using routine approaches. …”
Get full text

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…They play a critical role in various pathological conditions in humans, including cancer, by regulating a number of key processes involved in tumor formation and progression. …”
Get full text

Fructose and/or Sorbitol Intolerance in a Subgroup of Lactose Intolerant Patients by SR Mishkin, L Sablauskas, S Mishkin

“…Clinical characteristics common to this group included: symptomatic diarrhea (12.5%), history of foreign travel (5.8%), endoscopic and pathological evidence of gastritis and helicobacter infection (19.2 and 8.7%, respectively), nonspecific abnormalities of small bowel follow-through (15.4%), Crohn’s disease (8.7%) and colonic cliverticulosis (14.4%). …”
Get full text

The risk of believing that emotions are bad and uncontrollable: association with orthorexia nervosa by L. Vuillier, M. Greville-Harris, R. L. Moseley

“…The findings suggest that when emotions feel unhelpful or uncontrollable, and maladaptive strategies like suppression are employed, individuals may seek perceived control through pathologically 'healthy' eating. There is currently no diagnosis criteria for ON, and consequently no clear treatment pathway. …”
Get full text