Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy by Rui Shimazaki, Yoshihiko Saito, Tomonari Awaya, Narihiro Minami, Ryo Kurosawa, Motoyasu Hosokawa, Hiroaki Ohara, Shinichiro Hayashi, Akihide Takeuchi, Masatoshi Hagiwara, Yukiko K. Hayashi, Satoru Noguchi, Ichizo Nishino

“…Methods Clinical course and pathological findings were retrospectively reviewed in Japanese patients with SGP. …”
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Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe by Marco Valadares, Anne Carolyne Lelis Oliveira Pedroso, Alessandro Santana, Angela Maria da Silva, Isabela Soares Costa, Maria Luiza Doria Almeida, Roque Pacheco de Almeida

“…Other ocular alterations were seen in 15 (24.2%) patients, including pathological strabismus in 11 (17.7%) patients, congenital cataracts in 2 (3.2%) patients, and nystagmus in 2 (3.2%) patients. …”
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Solitary fibrous tumor of the orbit: The importance of the histopathological diagnosis of the hemangiopericytoma pattern by Débora Bertazzo, Simon Trottier, Carolina Santos, Luiza Abreu Minussi, Emily Marcotte, Miguel Noel Burnier

“…Conclusion: These results highlight the pathological variability of orbital SFT/HPC. Immunohistochemical profiling helps differentiate between SFT and SFT with HPC pattern, which is essential, as HPC have a higher risk of recurrence and malignant transformation.…”
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Toxicopathological Effects of the Venom of Echis ocellatus on Experimentally Envenomated Swiss Albino Rats by P. O. Yusuf, D. Ada, D. B. Nuhu, S. Dahiru, P. M. Ameh, M. Mamman, M. U. Kawu, M. Bisallah, S. J. Enam

“…These findings suggest the venom of Echis ocellatus induces significant hematotoxicity, with pathological involvement of the heart, liver, kidneys, and spleen. …”
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Short-term survivors with brain metastases have modest benefits from focal and systemic therapies and remain frequent despite improving treatment landscape by M. Czogalla, J. Stöhr, N. Gleim, K. Papsdorf, S. Klagges, P. Hambsch, T. Kuhnt, F. Nägler, A. Barrantes-Freer, J. Wach, N.H. Nicolay, C. Seidel

“…Clinical and treatment characteristics, pathological data and causes of death were documented. …”
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Diagnostic Role of Colon Capsule Endoscopy in Patients with Optimal Colon Cleaning by Ümit Akyüz, Yusuf Yılmaz, Ali Tüzün İnce, Bülent Kaya, Cengiz Pata

“…CCE appears to be a highly sensitive diagnostic modality for detecting colonic pathologies.…”
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Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon by Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya

“…Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations. …”
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Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer by Tao Du, Shun Zhang, Xi-Mao Cui, Ren-Hao Hu, Hai-Yan Wang, Jian-Juan Jiang, Jun Zhao, Lan Zhong, Xiao-Hua Jiang

“…Combined with postoperative pathological staging, there was no difference in diagnostic sensitivity and specificity of lymph node staging between the FDG and FAPI groups (P>0.05). …”
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A SYBR green I-based multiplex real-time PCR for simultaneous detection of pseudorabies virus, porcine circovirus 3 and porcine parvovirus by Lihua Cao, Wenke Lv, Anqi Li, Lulu Yang, Feng Zhou, Feng Wen, Sheng Yuan, Shujian Huang, Zhili Li, Jinyue Guo

“…Single infection or co-infection with PRV, PPV and/or PCV3 was difficult to distinguish between their clinical symptoms and pathological changes. Therefore, a quick and accurate detection method is needed for epidemiological surveillance, disease management, import and export control. …”
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Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population by Xueying Chen, Han Guo, Xinwei Li, Yang Liu, Xinxin Li, Zhengshuo Cui, Huijuan Ma, Jianxun He, Zhechun Zeng, Huina Zhang

“…Secreted protein acidic and rich in cysteine (SPARC) is involved in many metabolic diseases and endothelial dysfunction pathological processes. This study aimed to explore the association of serum EV‐derived SPARC with hypertension incidence. …”
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Oxytocin attenuates demand for cocaine in female rats by Amy S. Kohtz, Hannah Davies, Belle Lin, Gary Aston-Jones

“…There are substantial sex differences in substance use disorders (SUDs), and a key feature of SUD is pathologically high economic demand for drug. The hypothalamic neuropeptide oxytocin (OXT) is heavily implicated in the modern treatment of SUDs. …”
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Therapeutic potential of SOX family transcription factors in osteoarthritis by Yue Huang, Zhuo Wang

“…Scholarly investigations of the molecular mechanisms that are related to the occurrence and development of osteoarthritis have shed light on the pathological causes of this condition to a certain extent, providing a foundation for its prevention and treatment. …”
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Microbial diversity and metabolomics analysis of colon contents exposed to cadmium and polystyrene microplastics by Dechun Chen, Liyu Pan, Xuan Ran, Junyu Huang, Xiaohua Teng, Falong Yang, Haifeng Liu

“…The changes of colon histopathology were observed, and the changes of microbial diversity and metabolomics of colon contents were analyzed. Pathological sections of the colon showed abnormal mucosal hyperemia with mixed exposure compared to cadmium exposure. …”
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Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet by Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai

“…Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. …”
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Relationship between the ultrasound features of different molecular subtypes of breast cancer and positive PD-1/PD-L1 expression by Ruiqian Yan, Haixia Li, Junxi Gao

“…Methods The study included 172 invasive breast cancer patients with surgical resection and pathological confirmation at the First Affiliated Hospital of Xinjiang Medical University from June 2016 to April 2022. …”
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Development and validation of nomograms for predicting pentafecta outcomes before and after robot-assisted radical prostatectomy: a retrospective study by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…Nomograms were developed using preoperative and postoperative variables, including age, PSA level, biopsy Gleason score, clinical stage, pathological tumor stage, tumor grade, nerve sparing, and preoperative potency. …”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…Consistent with its multiple functions, the nucleolus has been implicated in many human diseases, including cancer and degenerative pathologies of the nervous system and heart. Here, we report the characterization of the Drosophila Non3 (Novel nucleolar protein 3) gene, which encodes a protein homologous to the human Brix domain-containing Rpf2 that has been shown to control ribosomal RNA (rRNA) processing. …”
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mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction by Seon-Yeong Lee, Jeonghyeon Moon, A Ram Lee, Young-Mee Moon, Jeong Won Choi, Chae Rim Lee, Su Been Jeon, Hee Su Sohn, Jeehee Youn, Dongyun Shin, Sung-Hwan Park, Mi-La Cho

“…Abstract Th17 cells are activated by STAT3 factors in the nucleus, and these factors are correlated with the pathologic progression of rheumatoid arthritis (RA). …”
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Toxicopathological Effects of the Venom of Echis ocellatus on Experimentally Envenomated Swiss Albino Rats by P. O. Yusuf, G. Ada, D. B. Nuhu, S. Dahiru, P. M. Ameh, M. Mamman, M. U. Kawu, M. Bisallah, S. J. Enam

“…These findings suggest the venom of Echis ocellatus induces significant hematotoxicity, with pathological involvement of the heart, liver, kidneys, and spleen. …”
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Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…In the presence of an intense stressing event, cells activate specific responses to counteract cell death or senescence which is known to act as a key-task in the onset of age-related pathologies and in the loss of tissue homeostasis. Many studies have shown positive effects of natural compounds as beer polyphenols on biological systems. …”
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