Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy by Miao Shen, Jie Lu, Weiqi Dai, Fan Wang, Ling Xu, Kan Chen, Lei He, Ping Cheng, Yan Zhang, Chengfen Wang, Dong Wu, Jing Yang, Rong Zhu, Huawei Zhang, Yinqun Zhou, Chuanyong Guo

“…Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and pathological features were significantly ameliorated by ethyl pyruvate (80 mg/kg). …”
Get full text

Plasmapheresis for extracorporeal membrane oxygenation (ECMO)-induced hemolysis in infants by Budhu Gail, Morris-Whyte Kaydeen, Constantinescu Alexandru R.

“…Therapeutic plasma exchange (TPE) in tandem with ECMO was described as a therapy for various pathologic conditions, but there are no Extracorporeal Life Support Organization (ELSO) guidelines for the treatment of ECMO-induced hemolysis. …”
Get full text

RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway by Yufang Ni, Hongmin Zhang, Qianwen Xian, Wenjie Qin, Hongwei Su, Li Wang, Jianchun Li

“…This study aimed to investigate the role of Circ1647 in renal fibrosis, which is a hallmark of CKD.Methods In this study, we established a unilateral ureteral obstruction (UUO) model and delivered Circ1647 RfxCas13d knockdown plasmid into renal parenchymal cells via retrograde injection through the ureter followed by electroporation. After that, the pathological changes were determined by Hematoxylin and Eosin. …”
Get full text

Immediate management of a cirrhosis-induced severe pericardial effusion: a case report and review of the literature by Maryam Taheri, Arash Hassanpour Dargah, Pedram Ramezani, Mohsen Anafje, Amir Nasrollahizadeh, Pouya Ebrahimi, Mohammad Hossein Mandegar

“…This case report details a 60-year-old male with autoimmune hepatitis-induced cirrhosis presenting with severe pericardial effusion and cardiac tamponade, emphasizing the interplay between liver and cardiac pathologies. Methods A 60-year-old Persian man presented with progressive dyspnea, chest pain, and significant weight gain due to fluid retention. …”
Get full text

VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L by Qiuwen Wu, Jiaxin Fu, Bin Zhu, Wei Meng, Jingyi Ma, Ying Lv, Wenqi Zhao, Fan Wang, Jingjin Liu, Yongshun Wang, Cong Peng, Shuo Zhang

“…Activation of VEGFR3 mitigated renal dysfunction, pathological damage, and oxidative stress in Ang II-induced hypertensive mice. …”
Get full text

Details of Walker 256 carcinosarcoma growth in Brattleboro and ISIAH lines of rats by I. I. Khegay

“…The growth dynamics of transplantable Walker 256 carcinosarcoma was investigated in rats modeling inherited systemic pathological processes. Hypothalamic diabetes insipidus is developing in Brattleboro rats on the background of total vasopressin absence in the blood. …”
Get full text

The Use of Voice Control in 3D Medical Data Visualization Implementation, Legal, and Ethical Issues by Miklos Vincze, Bela Molnar, Miklos Kozlovszky

“…In the first, we have designed and developed a system that allows the user to evaluate 3D pathological medical serial sections using voice commands. …”
Get full text

In vivo confocal microscopic study of cornea verticillata and limbus deposits in patients with Fabry disease by Xuecong Zhou, Yawen Zhao, Yingsi Li, Yujing Yuan, Xiaoming Yan, Wei Zhang, Yuan Wu

“…Patients with FD demonstrated a profound bilateral increase in corneal epithelial deposits and limbal hyperreflective cells compared to controls, with more prominent pathological changes observed in classical phenotype individuals. …”
Get full text

Improved ChIP Sequencing for H3K27ac Profiling and Super-Enhancer Analysis Assisted by Fluorescence-Activated Sorting of Formalin-Fixed Paraffin-Embedded Tissues by Nenggang Jiang, Zhihao Wen, Huan Tao, Hongyan Liao

“…These results show that ChIP-seq for H3K27ac profiling and SEs mapping assisted by FACS with pathological FFPE tissue is available for research of histone modification. …”
Get full text

Endoscopic band ligation versus hot snare resection for hyperplastic gastric polyps in cirrhotic patients by Maha Elsabaawy, Osama Elbahr, Ahmed Edrees, Reda Badr, Ahmed Kamal, Sameh Afify

“…Data of demographic, clinical, and pathological factors, hospitalization expenses and outcomes of both treatment maneuvers were collected and statistically analyzed. …”
Get full text

Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and fatty acid metabolism-associated gene by Hong Li, Yongyun Xu, Aiting Wang, Chuanxin Zhao, Man Zheng, Chunyan Xiang

“…Advancements in lipidomics and metabolomics have unveiled the complex role of fatty acid metabolism (FAM) in both healthy and pathological states. However, the specific roles of fatty acid metabolism-related genes (FAMGs) in shaping therapeutic approaches, especially in AS, remain largely unexplored and are a subject of ongoing research. …”
Get full text

Effects of orally exposed SiO2 nanoparticles on lipid profiles in gut-liver axis of mice by Kuanhang Li, Zhengzheng Zhou, Yi Cao

“…After 5 days exposure (once a day), we observed that SiO2 NPs induced minimal pathological changes but increased most of the trace elements. …”
Get full text

Medical care and initial health status of French children returnees from jihadist group operation areas: A cross-sectional study from 2017 to 2020 in one referral French hospital by J. Goutines, L.L. Pham, N. Lucidarme, C. Briand, A. Malka, C. Baker, M. Veyret-Morau, A. Mapelli, A. Klein, T. Baubet, L. De Pontual

“…At least one parent was deceased or incarcerated in respectively 25 (36 %) and 50 cases (71 %). Main pathologies were infectious diseases (n = 14, 20 %), including one lymph node tuberculosis. …”
Get full text

Standard Urine Collection Bag as an Improvised Bogotá Bag as a Temporary Abdominal Closure Method in an Open Abdomen in Preventing Abdominal Compartment Syndrome by Ahmed Shabhay, Zarina Shabhay, Kondo Chilonga, David Msuya, Theresia Mwakyembe, Samwel Chugulu

“…Primary abdominal wall closure post laparotomy is not always possible. Certain surgical pathologies such as degloving anterior abdominal wall trauma injuries and peritoneal visceral volume and cavity disproportion render it nearly impossible for the attending surgeon to close the abdomen in the first initial laparotomy. …”
Get full text

Generalized lymphatic anomaly in a pediatric patient manifesting as a rare presentation of hemorrhagic pleural effusion: a case report by Xuehong Zhang, Jiuling Wang, Shouxing Duan, Yongping Yan, Libin Wang

“…The mass in the left mediastinum was removed, and pathological examination confirmed hyperplasia and expansion of the papillary endothelial cells within the lymphatic vessels. …”
Get full text

Infiltration of CD8+ cytotoxic T-cells and expression of PD-1 and PD-L1 in ovarian clear cell carcinoma by Mengdi Fu, Huimei Zhou, Jiaxin Yang, Dongyan Cao, Zhen Yuan

“…Professional quantitative pathological analysis software was used to count the CD8+ cytotoxic T-cells in tumor regions and adjacent nonneoplastic regions in postoperative specimens. …”
Get full text

Spine surgery and readmission: Risk factors in lumbar corpectomy patients by Julius Gerstmeyer, MD, Anna Gorbacheva, August Avantaggio, Clifford Pierre, MD, Emre Yilmaz, MD, Thomas A. Schildhauer, MD, Amir Abdul-Jabbar, MD, Rod J Oskouian, MD, Jens R Chapman, MD

“…Conclusions: We established an all-cause 90-day readmission rate of 20.8%, which is in range of other procedures in spine surgery but underscores the severity of lumbar corpectomy. Underlying pathologies have a greater impact on the readmission rate compared to medical comorbidities. …”
Get full text

Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway by Zhong-Kun Bao, Yan-Hong Mi, Xiao-Yu Xiong, Xin-Hong Wang

“…H&E staining was used to observe the pathological changes of intestinal tissues. ELISA, immunohistochemical staining, and flow cytometry assays were used to detect the levels of inflammatory factors, including TNF-α, IL-6, and IL-17, the expression of Bax, Bcl-2, TLR4, and NF-κB, and the percentages of the Th17 and Treg cells, respectively. …”
Get full text

Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells by Huilong Li, Huilong Li, Haotian Lin, Haotian Lin, Tinghui Fan, Linfei Huang, Li Zhou, Xiaoyu Tian, Ruzhou Zhao, Yanhong Zhang, Xiaopan Yang, Luming Wan, Hui Zhong, Nan Jiang, Congwen Wei, Wei Chen, Wei Chen, Lihua Hou, Lihua Hou

“…A patient-derived xenotransplantation (PDX) mouse model was constructed to evaluate the pathological role of the SARS-CoV-2 spike protein (SARS-2-S). …”
Get full text

Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients by Yushi Nagaki, MD, PhD, Satoru Motoyama, MD, PhD, Yusuke Sato, MD, PhD, Akiyuki Wakita, MD, PhD, Hiromu Fujita, MD, PhD, Kohei Kemuriyama, MD, Ryohei Sasamori, MD, Shu Nozaki, MD, Kyoko Nomura, MD, PhD, Yoshihiro Minamiya, MD, PhD

“…Of 68 patients without a pathological complete response (non-pCR) in their primary tumor, 51 (75%) had hot tumors after NACRT. …”
Get full text