Normal Ranges of Left Atrial Strain and 3D Echocardiographic Volume Measurements in Türkiye by Özden Seçkin Göbüt, Serkan Ünlü, Burcu Cihan Talay

“…Methods: The echocardiographic data of one-hundred and forty-six volunteers without known cardiovascular pathologies were analyzed. 3D volume measurements and LA longitidinal strain in the reservoir, conduit, and contraction phase were investigated. …”
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Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy by LIU Siyu, LAI Yuezhao, GUO Wenting, CHEN Xuejin

“…This review briefly outlines the pathological mechanisms and genetic characteristics of DMD before delving into recent progress in therapeutic strategies, with a particular focus on nucleic acid drugs (including antisense oligonucleotides for exon skipping therapy and translation readthrough inducers) and gene therapy approaches (including gene replacement therapy and gene editing). …”
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PIWI proteins and piRNAs: key regulators of stem cell biology by Fernando Claro-Linares, Patricia Rojas-Ríos

“…Beyond their canonical roles, emerging evidence reveal their broader significance in maintaining stem cell properties and organismal health under physiological and pathological conditions.…”
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Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases by Mingyu Wu, Ke Li, Jiabin Wu, Xianyi Ding, Xiaotong Ma, Wenhong Wang, Weihua Xiao

“…., which mainly rely on the inhibition of apoptosis, strengthening endogenous anti-inflammatory and antioxidant mechanisms, activation of immune responses and regulation of efflux transport signals, to improve pathological changes in the liver caused by lipid deposition, inflammation, oxidative stress, accumulation of hepatotoxic product, etc. …”
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Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation by Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, Constantinos H. Davos, David J. Lefer, Andreas Papapetropoulos

“…In conclusion, this study found that reduced MPST/H2S exacerbates the pathological changes associated with MetS and contributes to vascular inflammation. …”
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Increased Intra-Abdominal Pressure as One of the Links in the Pathogenesis of Secondary Diffuse Purulent Peritonitis by D. V. Cherdantsev, O. V. Ovchinnikova, Yu. G. Trofimovich, I. G. Noskov, O. V. Pervova, A. A. Kovalenko

“…According to statistics, hospitalization of patients with signs of local or diffuse peritonitis is more than 15 % among patients with acute surgical pathologies. One of the factors in the development of complications and an unfavorable prognosis for this disease is increased intra-abdominal pressure. …”
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Prevalence of Proteinuria in Owned Dogs from Italy: A Multicentric Study by M. Gizzarelli, X. Roura, P. Scarpa, P. D'Ippolito, V. Foglia Manzillo, G. Oliva, A. Tarducci, A. Borrelli, G. Melis, F. Quintavalla, A. Uva, A. Guarraci, A. Zatelli

“…Early detection of proteinuria allows us to identify several pathological conditions. The aim of the study was screening a canine population not known as being proteinuric, by the urinary dipstick. …”
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Urethral Prolapse Case Report: Surgical and Social Considerations in Senegal by Mohamed Jalloh, Jennifer Heibig, Oumar Gaye, William Ghaul, Gabrielle Yankelevich, Medina Ndoye, Mouhamadou Moustapha Mbodji, Ayun Cassell, Lamine Niang, Serigne Magueye Gueye

“…In some countries, there are strong social considerations and they demonstrate difficulty separating sexual abuse from genitourinary pathologies, which are important to address in the treatment of these conditions.…”
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In Vitro Antioxidant, Anti-inflammatory, and In Vivo Anticolitis Effects of Combretin A and Combretin B on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Mbiantcha Marius, Dawe Amadou, Atsamo Albert Donatien, Ateufack Gilbert, Yousseu Nana William, Khalid Rauf, Mehreen Arif, Fanta Yadang Sabine Adeline, Njoku Isaac Saint, Hamza Dar, Naeem Ur Rehman, Izhar Ahmad

“…Combretum fragrans (Combretaceae) is a Cameroonian medicinal plant containing various secondary metabolites and traditionally used for the treatment of several pathologies. Two cycloartane-type triterpenes, Combretin A and Combretin B, were isolated from this plant. …”
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White matter hyperintensities and cholinergic degeneration as Lewy body disease by Sungwoo Kang, Seun Jeon, Yeoju Kim, Su‐Hee Jeon, Minsun Choi, Young‐gun Lee, Mijin Yun, Byoung Seok Ye

“…Anterior periventricular WMHs may represent axonal alterations caused by the interplay between Lewy body‐related degeneration and vascular pathologies.…”
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Golgi protein 73: charting new territories in diagnosing significant fibrosis in MASLD: a prospective cross-sectional study by Shan Hong, Ziyu Liu, Ping Li, Jing Zhang, Hongshan Wei

“…Clinical data and hepatic pathological features and the correlation between serum GP73 and liver fibrosis were assessed. …”
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Anti-oxidation enhancement, inflammation alleviation, and microbial composition optimization of using tussah (Antheraea pernyi) silk fibroin peptides for hyperglycaemia remission. by Rui Mi, Xuejun Li, Yajie Li, Xingfan Du

“…Moreover, TSFP could alleviate pathological damages and hinder inflammatory processes of diabetic mice. …”
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Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes by Cherilyn Uhm, Jianlei Gu, Weina Ju, Stephanie Pizzella, Hande Oktay, Joyce Yao-Chun Peng, Sararose Guariglia, Yong Liu, Hongyu Zhao, Yong Wang, Ramkumar Menon, Nanbert Zhong

“…The specific effects of placental trophoblasts on the pathological development of sPTB subtypes—preterm premature rupture of fetal membranes (pPROM) and spontaneous preterm labor (sPTL)—are not fully understood, making it crucial to uncover these impacts for the development of effective therapeutic strategies. …”
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Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequen... by Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato

“…Mutations that affected the expression and/or the function of nephrin, a key component of the slit-diaphragm, are often causes of these pathologies. Recent findings showed that murine podocytes could undergo epithelial-mesenchymal transformation (EMT), suggesting new hypotheses about the pathogenesis of glomerular fibrosis. …”
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Characterization of patients with ischemic cerebrovascular disease and cognitive impairment. Cienfuegos, 2018 by Beatriz Perdomo Borges, Teresa Rodríguez Rodríguez, Marianela Fonseca Fernández, Isabel Urquiza Pozo, Idalmis Luisa Martínez Serrano, Belkis Rosa Bilaboy Pérez

“…The variables were analyzed: sex, age, skin color, schooling, occupation, marital status, origin, toxic habits, personal pathological history, type of cerebrovascular disease, affected brain structure, cognitive impairment (using the minimum Folstein mental state test and the Montreal cognitive assessment test), neuropsychological alterations, depression (using the Yessavage geriatric depression scale).…”
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Blinded by the Mind: Exploring the Hidden Psychiatric Burden in Glaucoma Patients by Jeniffer Jesus, João Ambrósio, Dália Meira, Ignácio Rodriguez-Uña, João Melo Beirão

“…Given the high occurrence of psychiatric pathologies among individuals with glaucoma, it is essential to develop comprehensive care strategies that address both eye and mental health needs. …”
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Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer by Lourdes González-Longoria Boada, Secundino González Pardo, Francisco López Muñoz

“…<br /><strong>Objective:</strong> To determine the relationship between the clinical-pathological and histological characteristics with the IHC subtypes of BC in Ecuadorian patients. …”
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Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a viciou... by Yin Jin, Apostolia Topaloudi, Sudhanshu Shekhar, Guangxin Chen, Alicia Nicole Scott, Bryce David Colon, Petros Drineas, Chris Rochet, Peristera Paschou

“…Abstract Dementia refers to an umbrella phenotype of many different underlying pathologies with Alzheimer’s disease (AD) being the most common type. …”
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Metallic Full-Length Ureteral Stents: Does Urinary Tract Infection Cause Obstruction? by James A. Brown, Christopher L. Powell, Kristopher R. Carlson

“…Metallic ureteral stents may have utility for patients with pathological processes causing extrinsic ureteral compression refractory to the use of traditional polymer ureteral stents. …”
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Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages by Yanxia Fu, Jun Li, Mengdi Li, Junfeng Xu, Zheng Rong, Fangli Ren, Yinyin Wang, Jianqiu Sheng, Zhijie Chang

“…Indeed, HUC-MSCs dramatically ameliorated the disease symptoms and pathological changes of DSS-induced colitis mice. We deciphered the mechanism that HUC-MSCs inhibited tumorigenesis through reducing the proportion of macrophages, which were decreased in the mice suffered from AOM/DSS-induced colon cancer. …”
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