Ileostomy Prolapse in Children with Intestinal Dysmotility by Eric A. Sparks, Cristine S. Velazco, Brenna S. Fullerton, Jeremy G. Fisher, Faraz A. Khan, Amber M. Hall, Tom Jaksic, Leonel Rodriguez, Biren P. Modi

“…Primary outcome was pathologic stoma prolapse. Multivariate analysis using a logistic regression model and log-rank test to compare stoma prolapse rates over time between motility groups were used. …”
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Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases by Huang X, Yu W, Wei A, Wang X, Chen S

“…TRIM proteins modulate key pathological processes, including inflammation, fibrosis, and cellular remodeling, contributing to disease progression. …”
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Enhancing paddy leaf disease diagnosis -a hybrid CNN model using simulated thermal imaging by Jagamohan Padhi, Kunal Mishra, Ashoka Kumar Ratha, Santi Kumari Behera, Prabira Kumar Sethy, Aziz Nanthaamornphong

“…This research underscores the value of integrating thermal imaging with Deep Learning for advancing crop disease management and offers a framework for addressing other crop pathologies.…”
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Use of the Da Vinci SP surgical system in robot-assisted nipple-sparing mastectomy: a single-center, retrospective study by Sae Byul Lee, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Beom Seok Ko

“…Stage I (31, 47.1%) was the most common pathological tumor-node-metastasis stage, followed by stages II (22, 33.3%), 0 (7, 10.6%), and III (4, 6.0%). …”
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Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithms by Yi-Chou Chen, Hui-Chen Su, Shih-Ming Huang, Ching-Hsiao Yu, Jen-Huei Chang, Yi-Lin Chiu

“…Moreover, the interaction between immune cells and bone cells plays a crucial role in bone repair processes, highlighting the importance of osteoimmunology in understanding and treating bone pathologies. Methods This study aims to investigate the xCell signature-based immune cell profiles in osteoporotic patients with and without vertebral fractures, utilizing advanced predictive modeling through the XGBoost algorithm. …”
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FlashTag-mediated Labeling for Intraventricular Macrophages in the Embryonic Brain by Hisa Asai, Mizuki Ono, Takaki Miyata, Yuki Hattori

“…Microglia, the brain's immune cells, which play pivotal roles in both physiological and pathological contexts, begin colonizing the brain around embryonic day (E) 9.5 in mice, with their population expanding as development progresses. …”
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Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway by Qiao Shi, Kang-Shu Liao, Kai-Liang Zhao, Wei-Xing Wang, Teng Zuo, Wen-Hong Deng, Chen Chen, Jia Yu, Wen-Yi Guo, Xiao-Bo He, Ablikim Abliz, Peng Wang, Liang Zhao

“…Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1β, IL-6, and renal TNF-α, HMGB1, and (6) tyrosine nitration, IκB degradation, and NF-κB activation in renal tissues. …”
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From the right ventricle to the descending aorta: a Case Report of complex thrombotic events in a patient with nephrotic syndrome by Jiaojiao Chen, Longyin Zhu, Fen Zhou, Yuting Li, Tao Gu, Jing Xia

“…The etiological diagnosis was hepatitis B virus-associated glomerulonephritis, and the pathological diagnosis was mesangial proliferative glomerulonephritis. …”
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MicroRNA-132 Interact with p250GAP/Cdc42 Pathway in the Hippocampal Neuronal Culture Model of Acquired Epilepsy and Associated with Epileptogenesis Process by Jinxian Yuan, Hao Huang, Xin Zhou, Xi Liu, Shu Ou, Tao Xu, Ruohan Li, Limin Ma, Yangmei Chen

“…Increasing evidence suggests that epilepsy is the result of synaptic reorganization and pathological excitatory loop formation in the central nervous system; however, the mechanisms that regulate this process are not well understood. …”
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Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases by Wanyu Song, Xiuli Chen, Haiying Wu, Neda Rahimian

“…In this aspect, Circular RNAs (circRNAs) play a crucial role as epigenetic modifiers in a wide range of biological and pathological activities, including problems with fertility. …”
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Elevated ALOX12 in renal tissue predicts progression in diabetic kidney disease by Meixi Wang, Jingjing Wang, Jinni Wang, Yonggui Wu, Xiangming Qi

“…Clinical chemical and pathological data analysis indicated a correlation between ALOX12 protein expression and renal tubule injury. …”
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Individualized brain radiomics-based network tracks distinct subtypes and abnormal patterns in prodromal Parkinson's disease by Lin Hua, Canpeng Huang, Xinglin Zeng, Fei Gao, Zhen Yuan

“…Individuals in the prodromal phase of Parkinson's disease (PD) exhibit significant heterogeneity and can be divided into distinct subtypes based on clinical symptoms, pathological mechanisms, and brain network patterns. …”
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MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction by Hasahya Tony, Kai Meng, Bangwei Wu, Aijia Yu, Qiutang Zeng, Kunwu Yu, Yucheng Zhong

“…Aims. miR-208a is associated with adverse outcomes in several cardiac pathologies known to have increased apoptosis, including myocardial infarction (MI). …”
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Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies by Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing

“…Furthermore, the glomerular complement proteins of CP and AP were positively correlated with glomerular pathological grades and proteinuria, and negatively correlated with eGFR in DKD patients. …”
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African swine fever in the Republic of Crimea in 2015–2018 by N. G. Kosharny, S. I. Danylchenko, M. A. Pasunkina, D. V. Gadzevich, N. G. Vorotilova

“…In 2018, ASF virus was detected with polymerase chain reaction (PCR) in 8 samples of pathological materials from wild boars, that was 0.1% out of total number of the samples tested in the FGBI “ARRIAH” Branch in the Republic of Crimea and FGI RC “Regional State Veterinary Laboratory of the Republic of Crimea”. …”
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GLI1-altered mesenchymal tumor involving the parietal pleura: case report and literature review by Yuanli Zhong, Baizhou Li, Gangping Wang, Yuqing Liu, Zhenwei Chen

“…These tumors are predominantly located in the head and neck region and display distinctive pathological morphology and molecular characteristics. …”
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Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells by Jingjing Liang, Biao Chen, Yanmei Li, Daibang Nie, Changbin Lei, Qing Yang, Yiqin Zhou, Shenglong Li, Shuaizhi Chen, Bin Li, Lin Shu, Liaobin Chen, Wang Wang

“…Here, we investigated whether asymptomatic hyperuricemia was associated with spontaneous ruptures in the Achilles tendon and the pathological effect of hyperuricemia on the tendon stem/progenitor cells (TSPCs). …”
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Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…<b>Conclusions</b>: Reg proteins have dual functional roles under various physiological and pathological conditions. These theoretical foundations facilitate the subsequent development of diagnostic reagents and therapeutic drugs targeting Reg proteins.…”
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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity by Evelyn F Okal, Philip A. Romero, Pete Heinzelman

“…Abstract Background Angiotensin-Converting Enzyme 2 (ACE2) is a crucial peptidase in human peptide hormone signaling, catalyzing the conversion of Angiotensin-II to Angiotensin-(1–7), which activates the Mas receptor and elicits vasodilation, increased blood flow, reduced inflammation, and decreased pathological tissue remodeling. This study leverages protein engineering to enhance ACE2’s therapeutic potential for treating conditions such as respiratory viral infections, acute respiratory distress syndrome, and diabetes. …”
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Unveiling immune cell response disparities in human primary cancer-associated fibroblasts between two- and three-dimensional cultures. by Jian-Ping Yang, Nikhil Nitin Kulkarni, Masashi Yamaji, Tsubasa Shiraishi, Thang Pham, Han Do, Nicole Aiello, Michael Shaw, Toshihiro Nakamura, Akiko Abiru, Narender R Gavva, Shane R Horman

“…Remarkably, when cultured in 2D, CAFs exhibited a myofibroblast (myCAF) subtype, whereas in 3D tumor spheroid cultures, CAFs displayed a more inflammatory (iCAF) pathological state. By integrating single-cell gene expression data with functional interrogations of critical TME-related processes [natural killer (NK)-mediated tumor killing, monocyte migration, and macrophage differentiation], we were able to reconcile form with function. …”
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