Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…A label-free, mass spectrometry–based quantitative proteomics has been developed to identify and characterize proteins that are differentially expressed in GBM to gain a better understanding of the interactions and functions that lead to the pathological state focusing on the extracellular matrix (ECM). …”
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An unstable variant of GAP43 leads to neurodevelopmental deficiency by Mariko Noda, Ayumi Matsumoto, Hidenori Ito, Masayo Kagami, Toshihiro Tajima, Takayoshi Matsumura, Takanori Yamagata, Koh-ichi Nagata

“…Collectively, these findings confirmed the critical roles of GAP43 in brain development and the pathological basis of GAP43-associated diseases. Our study will contribute to a better understanding of how dysregulation of GAP43 leads to human diseases.…”
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Static Foot Disorders as a Risk Factor for the Development of Chronic Venous Disease: A Cross-sectional, Single-center Study by Nischal Soti, Prajjwol Luitel, Sujan Paudel, Ishwor Thapaliya, Ujjwal Gorsi, Ajay Savlania

“…Methodology: This study was performed at the Department of General Surgery, Postgraduate Institute of Medical Education and Research to study the relationship between the SFDs and clinical, etiological, anatomical, and pathological elements (CEAP) clinical severity in the Indian population. …”
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Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…The primary cause of pain and disability in the world is osteoarthritis (OA), a common joint disease characterized by the primary pathological alteration in articular cartilage deterioration. …”
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Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy by Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J. Kopsky

“…PEA has been evaluated for glaucoma, diabetic retinopathy, and uveitis, pathological states based on chronic inflammation, respiratory disorders, and various pain syndromes in a number of clinical trials since the 70s of 20th century. …”
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The role of DNA methylation in the disorders of bone metabolism by B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva, R. I. Khusainova

“…The purpose of this review is to compile and systematize data on the role of DNA methylation in bone metabolism in normal and pathological conditions, in the formation of osteoporosis, and to assess achievements and trends in this field of research and technologies for studying DNA methylation.…”
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In the footsteps of Covid-19 convalescence by Alfredo Espinosa Brito

“…Some practical recommendations are proposed, such as a) Include the information of having suffered from COVID-19 in the patients' personal pathological history; b) Insist on periodic monitoring of patients, especially those who express complaints of prolonged convalescence. …”
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Convolutional neural networks for diabetic retinopathy detection by Darwin Patiño-Pérez, Luis Armijos-Valarezo, Luis Chóez-Acosta, Freddy Burgos-Robalino

“… The early detection of diabetic retinopathy remains a critical challenge in medical diagnostics, with deep learning techniques in artificial intelligence offering promising solutions for identifying pathological patterns in retinal images. This study evaluates and compares the performance of three convolutional neural network (CNN) architectures ResNet-18, ResNet-50, and a custom, non-pretrained CNN using a dataset of retinal images classified into five categories. …”
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The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease by Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Deng

“…Diabetic kidney disease (DKD) is the most common microvascular complication of diabetes and is one of the main causes of end-stage renal disease (ESRD) in many countries. The pathological features of DKD are the hypertrophy of mesangial cells, apoptosis of podocytes, glomerular basement membrane (GBM) thickening, accumulation of extracellular matrix (ECM), glomerular sclerosis, and tubulointerstitial fibrosis. …”
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Uncovering functional lncRNAs by scRNA-seq with ELATUS by Enrique Goñi, Aina Maria Mas, Jovanna Gonzalez, Amaya Abad, Marta Santisteban, Puri Fortes, Maite Huarte, Mikel Hernaez

“…Abstract Long non-coding RNAs (lncRNAs) play fundamental roles in cellular processes and pathologies, regulating gene expression at multiple levels. …”
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Dural Injury Treatment with a Full-Endoscopic Transforaminal Approach: A Case Report and Description of Surgical Technique by João Paulo Machado Bergamaschi, Fernando Flores de Araújo, Thiago Queiroz Soares, Kelsen de Oliveira Teixeira, Luiz Henrique Dias Sandon, Ricardo Graciano Squiapati, Gustavo Vitelli Depieri, Ariel Falbel Lugão, Rangel Roberto de Assis, Esthael Cristina Querido Avelar Bergamaschi

“…Endoscopic spine surgery was initially described for lumbar disc pathologies. Technical advances and new materials have made it possible to treat cervical and thoracic spinal degenerative disorders. …”
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Transoral Laser-Assisted Total Laryngectomy: Expanding the TLM’s World by Aslan Ahmadi, Saleh Mohebbi, Masoud Kazemi, Ayda Sanaei

“…In this case report, we describe a case of a 50-year-old male patient presented to the otorhinolaryngology clinic with a history of hoarseness and odynophagia since 6 months. Based on the pathological and imaging findings, the diagnosis of stage IVa laryngeal squamous cell carcinoma with the involvement of the base, tongue, and left palatine tonsil was made for the patient, and transoral total laryngectomy with partial glossectomy via the TLM technique was planned. …”
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Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts by Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao

“…However, graft failure that results from suboptimal regeneration and pathological remodeling has hindered their clinical adoption. …”
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Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice by Karakoz Badekova, Gayane Atazhanova, Irina Losseva, Aigul Medeshova, Ailazzat Aitkenova, Anar Brazhanova

“…In case of studying the safety of anticaries dental gel “ACDG3” in animals, that with a single dose of up to 2000 mg/kg, the absence of pathological changes in the behavior of animals was noted. …”
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L-theanine modulates tissue cortisol levels in zebrafish after single stress by Vinícius Luís da Silva, Mariana Spanamberg Mayer, Andriele dos Reis Severo, Andressa Leal Zambra, Joanna Moraes De Almeida, Laura Moura Sestari, Mariana Migliorini Parisi, Ana Cristina Vendrametto Varrone Giacomini, Murilo Sander De Abreu, Josiane Woutheres Bortolotto, Gabriela Bonfanti-Azzolin

“…Thus, we conclude that the administration of L-theanine can promote acute stress attenuation, modulating the pathological responses of stress.…”
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Navigating the complex role of senescence in liver disease by Qiuting Li, Lin Wang, Yuanyuan Ji

“…Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to aging or pathological stress significantly contributes to chronic liver diseases, including alcoholic liver disease, metabolic dysfunction-associated steatohepatitis, liver fibrosis, and hepatocellular carcinoma. …”
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The bronchoalveolar lavage fluid CD44 as a marker for pulmonary fibrosis in diffuse parenchymal lung diseases by Magda Suchankova, Magda Suchankova, Eszter Zsemlye, Eszter Zsemlye, Jan Urban, Peter Baráth, Lenka Kohútová, Barbara Siváková, Barbara Siváková, Martina Ganovska, Elena Tibenska, Kinga Szaboova, Eva Tedlova, Dominik Juskanic, Dominik Juskanic, Kristina Kluckova, Kristina Kluckova, Michaela Kardohelyova, Tetiana Moskalets, Anna Ohradanova-Repic, Patrik Babulic, Maria Bucova, Vladimir Leksa

“…IntroductionDiffuse parenchymal lung diseases (DPLD) cover heterogeneous types of lung disorders. Among many pathological phenotypes, pulmonary fibrosis is the most devastating and represents a characteristic sign of idiopathic pulmonary fibrosis (IPF). …”
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Increased PPARD Expression May Play a Protective Role in Human Lung Adenocarcinoma and Squamous Cell Carcinoma by Yong Zhu, Yedong Mi, Zhonghua Qin, Xuewei Jiang, Yibo Shan, Kamil Kural, Guiping Yu

“…The potential roles of PPARD in the pathological development of LA and LSCC were explored through literature-based pathway analysis and pathway enrichment analysis. …”
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PET CT Imaging with FDG in the Therapeutical Management of Locally Advanced Cervical Cancer Diagnosed in a 43-Year-Old Patient: Case Report and Review of the Literature by Ottó Molnar, Simona Mihuțiu, Oreste Mihai Straciuc, Alexandra Vesa, Liviu Lazar

“…<b>Methods:</b> In the present case study, we report a 43-year-old female patient suffering from cervical cancer belonging to urban origin, with no personal pathological history, who presented herself to the gynecology department of the Bihor County Emergency Clinical hospital with vaginal bleeding. …”
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Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats by Wenjuan Liu, Wei Gong, Min He, Yemei Liu, Yeping Yang, Meng Wang, Meng Wu, Shizhe Guo, Yifei Yu, Xuanchun Wang, Fei Sun, Yiming Li, Linuo Zhou, Shengmei Qin, Zhaoyun Zhang

“…Cardiac structure was investigated with transmission electron microscopy and pathological examination; immunohistochemistry was performed to detect nitrotyrosine, collagen-1, TGF-β1, TNF-α, and F4/80 expression; and gene expression of markers for oxidative stress, inflammation, fibrosis, and energy metabolism was detected. …”
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