4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis by Yu-pu Hong, Wen-yi Guo, Wei-xing Wang, Liang Zhao, Ming-wei Xiang, Fang-chao Mei, Ablikim Abliz, Peng Hu, Wen-hong Deng, Jia Yu

“…Results showed that 4-PBA attenuated the following: (1) pancreas and islet pathological injuries, (2) serum TNF-α and IL-1β, (3) serum insulin and glucose, (4) beta-cell ultrastructural changes, (5) ER stress markers (BiP, ORP150, and CHOP), Caspase-3, and insulin expression in islet. …”
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Modulatory action of Bryonia alba on the immune system in cyclophosphamide induced immunosuppression in BALB/c mice. by Vara Prasad Saka, Godlaveti Vijay Narasimha Kumar, Abanti Goswami, Bharat Kumar Reddy Sanapalli, Pankaj Gupta, Digvijay Verma, Subhash Kaushik

“…Oxidative stress and inflammation are the most common pathologies in immune-compromised diseases and cancer treatments. …”
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Hypothesis: glyphosate-based herbicides can increase risk of hematopoietic malignancies through extended persistence in bone by Charles M. Benbrook

“…Animal bioassays and epidemiology studies link GLY/GBH exposures to heightened risk of blood cancers, and possibly other pathologies. The hypothesis proposed here provides a plausible pathophysiologic basis for these observations relative, in particular, to blood cancers.…”
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Occurrence of the Elongated Styloid Process on Digital Panoramic Radiographs in the Riyadh Population by Lingam Amara Swapna, Nada Tarek AlMegbil, Alhanouf Othman Almutlaq, Pradeep Koppolu

“…These patients could be misdiagnosed as other orofacial pathologies. Aim. The present study attempted to assess the prevalence of the elongated styloid process on digital panoramic radiographs in the Riyadh population. …”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…Innate immunity changes revealed in last years, related to mutations of genes of bacterial structures receptors (NOD2, toll-like receptors, autophagy), cause disorder of endocellular signal processes and pathological activation of cells of adaptive immunodefense of intestinal mucosa and conforming profile of cytokines with development of chronic inflammation which will be mediated: at Crohn's disease – by Th1-and Th17-cells, cytokines IL-12, interferon-γ etc., at ulcerative colitis – by Th2-and NKT-cells, cytokines IL-4 and IL-3 in combination to incompetence of suppressor function of regulatory Т-cells and their cytokines TGF-β (transforming growth factor) and IL-10.Conclusion. …”
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Differential microvascular endothelial cell responses in the retina in diabetes compared to the heart and kidneys, a spatial transcriptomic analysis. by Eric Wang, Biao Feng, Shali Chen, Zhaoliang Su, Subrata Chakrabarti

“…These findings show that organ specific MEC heterogeneity can influence differential development of pathological changes across various target organs of chronic diabetic complications, and suggest that MEC heterogeneity may influence treatment target(s) and drug development.…”
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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

“…Neurodegenerative diseases are characterized by the progressive breakdown of neuronal structure and function and the pathological accumulation of misfolded protein aggregates and toxic protein oligomers. …”
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia by Jingjin Li, Chonglong Shi, Zhengnian Ding, Wenjie Jin

“…It has been consistently reported that the pathological process of this clinical syndrome is related to neuroinflammation and microglial proliferation. …”
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Bladder Tumor in Women with Microscopic Hematuria: An Iranian Experience and a Review of the Literature by Shahin Abbaszadeh, Saeed Taheri, Mohammad Hossein Nourbala

“…Final diagnosis of malignant tumors was done with cystoscopy and biopsy specimen pathological assessment in all cases. Results. Age for the study population was 49.7±11.8 years. 95 (38%) of patients were identified during routine check up and presenting symptoms in other patients were frequency, dysuria, stress urge incontinence, urge incontinence, feeling of incomplete urine emptying, and flunk pain, respectively. …”
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Towards a Vaccine Against Rheumatic Fever by L. Guilherme, K. C. Faé, F. Higa, L. Chaves, S. E. Oshiro, S. Freschi de Barros, C. Puschel, M. A. Juliano, A. C. Tanaka, G. Spina, J. Kalil

“…We have been studying the mechanisms leading to pathological autoimmunity in RF/RHD for the last 15 years. …”
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Current research status of Traditional Chinese Medicine nursing for patients with sleep disorder after stroke (脑卒中后睡眠障碍中医护理技术研究现状) by HU Haixia (胡海霞), LIANG Haiyun (梁海云), HAN Xuelian (韩雪莲), XIE Ying (谢影), LI Yanmei (李艳梅)

“…There are many causes of post-stroke sleep disorders, including clinical medication, patients' own psychological factors, pathological damage, etc. From the perspective of Traditional Chinese medicine nursing and analysis of actual situation of patients with post-stroke sleep disorders, this study reviewed the studies on Traditional Chinese Medicine nursing for patients with sleep disorder after stroke, and provided reference for clinical decision making and nursing practice. …”
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Long-Term Survival and Risk Factors in Patients with Hepatitis B-Related Hepatocellular Carcinoma: A Real-World Study by Yu Zhu, Ling-Ling Gu, Fa-Biao Zhang, Guo-Qun Zheng, Ting Chen, Wei-Dong Jia

“…A retrospective cohort study was conducted to collect 465 patients with hepatitis B-related hepatocellular carcinoma who had undergone radical hepatectomy from January 1, 2012, to August 31, 2018, at the First Affiliated Hospital of the University of Science and Technology of China. The clinical, pathological, and follow-up information was collected to compare the basic characteristics of death and nondeath after radical resection. …”
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SESN2 ablation weakens exercise benefits on resilience of gut microbiota following high-fat diet consumption in mice by Chunxia Yu, Peng Zhang, Sujuan Liu, Yanmei Niu, Li Fu

“…Gut dysbiosis is associated with several pathological processes. Previous study showed that regular exercise can protect against dysmetabolism in high-fat diet (HFD) fed mice through butyrate-SESN2 pathway, and SESN2 ablation weakened the protective effects of exercise. …”
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Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Quantifying peripheral Cf-DNA and the specific differential methylation of a group of genes have been proposed as potential non-invasive diagnostic biomarkers for somatic and constitutional genetics and for various other pathological disorders. In this study, we investigated the Cf-DNA levels of 78 young women, 38 of whom had endometriosis confirmed via laparoscopy and 40 of whom were healthy. …”
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Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres by Ziyue Li, Yu Qiang, Dongli Chen, Dehong Hu, Duyang Gao, Xiaohua Xu, Lei Sun, Yingjia Li, Weibao Qiu, Zonghai Sheng

“…Traditional imaging modalities, such as magnetic resonance imaging and computed tomography, while effective for identifying stroke locations, are often limited in their ability to detect early pathological changes due to constraints in spatial resolution and sensitivity. …”
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A latent diffusion approach to visual attribution in medical imaging by Ammar Adeel Siddiqui, Santosh Tirunagari, Tehseen Zia, David Windridge

“…We perform experiments and quantitatively evaluate our results on the COVID-19 Radiography Database containing labelled chest X-rays with differing pathologies via the Frechet Inception Distance (FID), Structural Similarity (SSIM) and Multi Scale Structural Similarity Metric (MS-SSIM) metrics obtained between real and generated images. …”
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Primary large B-cell lymphoma of the central nervous system misdiagnosed as autoimmune encephalitis: a case report by Aihui Ren, Guanwen Zeng, Riling Chen, Zhixing Cao, Wenyan Zhuo, Yubin Liang, Yubin Liang

“…Thus, for patients with suspected CNS immune-mediated diseases who relapse after steroid treatment improvement, comprehensive evaluation including CSF examination, MRI, and prompt pathological examination is crucial to consider the possibility of PCNSL.…”
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Polymyalgia Rheumatica Revealing a Lymphoma: A Two-Case Report by Frank Verhoeven, Xavier Guillot, Mickaël Chouk, Clément Prati, Daniel Wendling

“…PET-CT revealed bursitis of the hips and the shoulders, no prostatic cancer recurrence, and a metabolically active iliac lymphadenopathy whose pathologic exam concluded to a low grade follicular lymphoma. …”
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An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy by Zunaira Qureshi, Murtaza Najabat Ali, Minahil Khalid

“…Unfortunately, there is no internationally recommended drug that directly hinders the pathological mechanisms that result in painful diabetic neuropathy. …”
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Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin by Burak BILGIN, Mete GULER, Hulya CICEK, Selma URFALIOGLU, Gokhan KOKUSARI, Bedia MARANGOZOGLU SAHIN

“…Progranulin (PGRN) has complex functions in many physiological and pathological processes. Thus, this study aimed to report vitreous AREG and PGRN levels in patients with diabetes and proliferative retinopathy and compare the results with those without diabetes. …”
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