Exploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids by Ann-Kathrin Lederer, Nele Görrissen, Tinh Thi Nguyen, Clemens Kreutz, Hannah Rasel, Fabian Bartsch, Hauke Lang, Kristina Endres

“…Organoids are 3D cell models cultivated in a modifiable and controlled condition, which can be grown from tumor tissue. 3D cell models are able to imitate physiological and pathological processes in the human body and thus contribute to a better understanding of health and disease. …”
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Long read Nanopore sequencing identifies precise breakpoints of a de novo paracentric inversion that disrupt the MEIS2 gene in a Chinese girl with syndromic developmental delay by Jianxin Tan, Mingtao Huang, Xiuqing Ji, An Liu, Fengchang Qiao, Cuiping Zhang, Lulu Meng, Yan Wang, Zhengfeng Xu, Ping Hu

“…Case presentation Herein, we report a Chinese girl with intellectual disability, developmental delay, and congenital heart defect, in whom G-banded karyotype analysis identified a de novo paracentric inversion 46,XX, inv(15)(q15q26.1) and other conventional approaches including chromosomal microarray analysis and whole exome sequencing were failed to detect any pathologic variants that can explain the phenotypes of the proband. …”
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Co-opting the ‘public’ in public health: homelessness and the specious logic of discretionary displacement in a mid-sized US city by Lesley Jo Weaver, Claire W. Herbert, Dylan J. Podrabsky, Mackenzie L. Ní Flainn

“…We find that authorities draw on sensationalized ‘disease-model’ logics of health risk that pathologize PEH as vectors of infectious disease and drug-related harms. …”
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Expression of Otx Genes in Müller Cells Using an In Vitro Experimental Model of Retinal Hypoxia by Claudio Azzolini, Simone Donati, Giovanni Micheloni, Vittoria Moretti, Roberto Valli, Francesco Acquati, Lucy Costantino, Fulvio Ferrara, Davide Borroni, Elias Premi, Francesco Testa, Francesca Simonelli, Giovanni Porta

“…The improved comprehension of these cellular events will be useful for designing new therapeutical approaches for retinal pathologies.…”
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Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca2+-Dependent Mechanisms by Li-Hua Yao, Hui-Min Yu, Qiu-Ping Xiong, Wei Sun, Yan-Liang Xu, Wei Meng, Yu-Ping Li, Xin-Ping Liu, Chun-Hua Yuan

“…Compound nerve action potential (CNAP), which is critical in signal conduction in the peripheral nervous system, is necessary to regulate physical performance, including motor system physiological and pathological processes. Therefore, regulatory effects of cordycepin on CNAP conduction should be elucidated. …”
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Evaluation of Absolute Neutrophil Count in the Perioperative Setting of Sarcoma Resection by Gayathri Vijayakumar, Emma M. Steffer, Neil P. Buac, Matthew W. Colman, Steven Gitelis, Alan T. Blank

“…The only independent predictor of worse overall survival was the presence of a pathologic fracture at the time of surgery. Conclusion. …”
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Inducible Lentivirus-Mediated siRNA against TLR4 Reduces Nociception in a Rat Model of Bone Cancer Pain by Ruirui Pan, Huiting Di, Jinming Zhang, Zhangxiang Huang, Yuming Sun, Weifeng Yu, Feixiang Wu

“…Although bone cancer pain is still not fully understood by scientists and clinicians alike, studies suggest that toll like receptor 4 (TLR4) plays an important role in the initiation and/or maintenance of pathological pain state in bone cancer pain. A promising treatment for bone cancer pain is the downregulation of TLR4 by RNA interference; however, naked siRNA (small interference RNA) is not effective in long-term treatments. …”
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Application of Anterior Segment Optical Coherence Tomography in Pediatric Ophthalmology by Ricardo Salles Cauduro, Caroline do Amaral Ferraz, Maira Saad Ávila Morales, Patricia Novita Garcia, Yara Cristina Lopes, Paulo Henrique Souza, Norma Allemann

“…Retrospective clinical study case series of 26 eyes of 19 pediatric patients throughout a 21-month period, presenting anterior segment pathologies, were submitted to AS-OCT examination (OCT Visante, 1310 nm, Zeiss), noncontact technique, no sedation requirement. …”
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Engineered tRNAs efficiently suppress CDKL5 premature termination codons by Stefano Pezzini, Aurora Mustaccia, Pierre Aboa, Giorgia Faustini, Alessio Branchini, Mirko Pinotti, Angelisa Frasca, Joseph J. Porter, John D. Lueck, Nicoletta Landsberger

“…The recoded CDKL5 is correctly localized and catalytically active, thereby bringing tRNA-based therapy back into the spotlight for future investigations to assess the efficacy of this approach in correcting the pathological phenotype of CDD.…”
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Diet-related dental wear in archaeological human populations of Chalcolithic and Bronze Age from North-Eastern Romania by Ozana-Maria Petraru, Luminița Bejenaru, Mariana Popovici

“…Dental macrowear is the non-pathological loss of hard tissues on the occlusal surface of the teeth. …”
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Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack by Zeqi Hao, Yulin Song, Yuyu Shi, Hongyu Xi, Hongqiang Zhang, Mengqi Zhao, Jiahao Yu, Lina Huang, Huayun Li

“…This could help further elucidate the pathological mechanisms of motor impairment in individuals with TIA and provide a new perspective for future early diagnosis and intervention for TIA.…”
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Prenatal Diagnosis and Postnatal Ultrasound Findings of Cloacal Anomaly: A Case Report by Lívia Teresa Moreira Rios, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, Ana Carolina Rabachini Caetano, Antonio Fernandes Moron, Marília da Glória Martins

“…Cloacal malformation is an extremely rare fetal pathological condition that presents as a variety of defects. …”
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Risk factors for radial artery calcification in patients with and without uremia by Jian-bing Hao, Si-yu Wang, Tong Chen, Bo Yuan, Li-rong Hao

“…General biochemical indicators and calcification-related molecules were collected and detected via ELISA or correlation analysis. In addition, pathological changes and calcification-related molecules in the radial artery were evaluated by HE or immunohistochemical staining. …”
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A Unique Case of Incomplete Bifid Ureter and Associated Arterial Variations by Shivika Ahuja, Hannah Sullivan, Mark Noller, Yun Tan, Daniel Daly

“…Ureteral compression can then result in several pathologies including reflux, urinary tract infection (UTI), ureteropelvic junction obstruction, or hydronephrosis. …”
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« On est encore en vie, à la grande surprise de tout le monde… » L’expérience des personnes âgées trans vivant avec une démence dans une société âgiste, cisgenriste et cogniticiste... by Alexandre Baril, Marjorie Silverman

“…Trans and non-binary older adults living with dementia experience forms of marginalization, pathologization, and discrimination embedded in epistemic violence that leads them to be mistreated and dismissed as knowledgeable subjects. …”
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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment by Fatih Ciftci, Ali Can Özarslan, İmran Cagri Kantarci, Aslihan Yelkenci, Ozlem Tavukcuoglu, Mansour Ghorbanpour

“…Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. …”
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In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of... by Aurélie Louit, Marie-Josée Beaudet, Mathieu Blais, François Gros-Louis, Nicolas Dupré, François Berthod

“…These results indicate that it is possible to recapitulate in vitro, at least in part, the ARSACS pathological signature in vitro using patient-derived motor neurons and Purkinje cells differentiated from iPSCs. …”
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A potential innovative surrogate marker for hypoxic injury: Shehata marker of angiogenesis by Shehata A. Mohamed

“…Objective: Many factors regulate the process of angiogenesis under physiological and pathological conditions. However, no reliable marker is currently available that can predict the patient's pro-angiogenic status, which might reliably reflect or predict certain clinical outcomes. …”
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A rare case of brain hemorrhage secondary to venous angioma in the right parietal lobe: case report and literature review by Juan Manuel Altamirano, Karla Salinas-Barboza, Eduardo Lopez-Ortiz, Luis Miguel Alfonso Fernandez-Gutiérrez

“…Conclusions This case underscores the importance of thorough pathological assessment and advanced imaging in accurately diagnosing DVAs. …”
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Humoral Bone Morphogenetic Protein 2 Is Sufficient for Inducing Breast Cancer Microcalcification by Fangbing Liu, Nathalie Bloch, Kumar R. Bhushan, Alec M. De Grand, Eiichi Tanaka, Stephanie Solazzo, Pawel M. Mertyna, Nahum Goldberg, John V. Frangioni, Robert E. Lenkinski

“…Bone morphogenetic protein 2 (BMP-2) is a key mediator of physiologic bone formation and pathologic vasculature calcification, but its role in breast cancer microcalcification is unknown. …”
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