Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Intervention... by Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S. Stone

“…Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. …”
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Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria by Adewumi Adediran, Kikelomo Wright, Akinsegun Akinbami, Adedoyin Dosunmu, Olajumoke Oshinaike, Bodunrin Osikomaiya, Sarah Ajibola, Kamal Ismail, Ebele Uche, Olaitan Ojelabi

“…Background. Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation. …”
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Current Status of Treatment of Spinal and Bulbar Muscular Atrophy by Fumiaki Tanaka, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Hiroaki Adachi, Gen Sobue

“…Spinal and bulbar muscular atrophy (SBMA) is the first member identified among polyglutamine diseases characterized by slowly progressive muscle weakness and atrophy of the bulbar, facial, and limb muscles pathologically associated with motor neuron loss in the spinal cord and brainstem. …”
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From Homeostasis to Neuroinflammation: Insights into Cellular and Molecular Interactions and Network Dynamics by Ludmila Müller, Svetlana Di Benedetto, Viktor Müller

“…Under homeostatic conditions, these elements promote cellular cooperation and stability, whereas in neuroinflammatory states, they drive adaptive responses that may become pathological if dysregulated. We examine how neuroimmune interactions, mediated through these cellular actors and signaling pathways, create complex networks that regulate CNS functionality and respond to injury or inflammation. …”
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Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice by Qin Wang, Jianchun Wang, Mingdong Hu, Yu Yang, Liang Guo, Jing Xu, Chuanjiang Lei, Yan Jiao, JianCheng Xu

“…UCP2 overexpression in mouse lungs increased LPS-induced pathological changes, lung permeability, lung inflammation, and lowered survival rates. …”
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Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer by Wencui Kong, Zongyang Yu, Wenwu Wang, Jingrong Yang, Jingfang Wang, Zhongquan Zhao

“…We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods. …”
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Investigation and Analysis of Cognition of Upper Limb Lymphedema in Postoperative Breast Cancer Patients by Xuelin YUAN, Na XIE, Liuya JIANG, Li LI, Jie JIA

“…Objective:A self-designed questionnaire was used to investigate the knowledge of upper limb lymphedema in postoperative breast cancer patients, and to provide direction for targeted health education.Methods:A total of 100 patients with pathologically diagnosed as breast cancer were selected as study objects by convenient sampling method. …”
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PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections by Masashi Ninomiya, Yoshiyuki Ueno, Tooru Shimosegawa

“…Several factors were proposed to clarify the pathological and immunological mechanisms of PBC. Immunological reaction with a bacterial or a viral association was identified in the previous report, and it seems probable that PBC was thought to have such an etiology. …”
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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…As “in vitro micro-organs”, organoids can faithfully recapitulate the organogenesis process, and conserve the key structure, physiological function and pathological state of the original tissue or organ. Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. …”
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Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma by Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen, Zhengwei Duan, Yonghao Guan, Kaiyuan Liu, Anquan Shang, Zihua Li

“…Validation cohorts, immunohistochemistry, and quantitative reverse transcription polymerase chain reaction confirmed that the predictor derived from these three genes possessed prognostic and pathological relevance. Our senescence predictor provides comprehensive insights into the molecular mechanisms of SARC and identifies potential biomarkers for prognosis, paving the way for effective treatments. …”
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An algorithm for cardiac disease detection based on the magnetic resonance imaging by Heng Li, Qingni Yuan, Yi Wang, Pengju Qu, Chunhui Jiang, Hu Kuang

“…Finally, comparative experiments were conducted on the Automated Cardiac Diagnosis Challenge cardiac MRI image dataset where it was found that SA-YOLOv8 achieved better results in detecting cardiac pathologies, and improvement of 7.4% in mAP0.5 value and 5.1% in mAP0.5-0.95 value compared to the baseline model.…”
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Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis by Mónica Kurte, Javiera Bravo-Alegría, Alexander Torres, Vania Carrasco, Cristina Ibáñez, Ana María Vega-Letter, Catalina Fernández-O’Ryan, Carlos E. Irarrázabal, Fernando E. Figueroa, Rodrigo A. Fuentealba, Claudia Riedel, Flavio Carrión

“…These results suggest that the inflammatory status is important to be considered for administering MSCs in autoimmune pathologies, leading to a further research to clarify the effect of MSCs for multiple sclerosis.…”
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Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior by Dario Coletti, Emanuele Berardi, Paola Aulino, Eleonora Rossi, Viviana Moresi, Zhenlin Li, Sergio Adamo

“…Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. …”
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Influence of nano-polystyrene on cyfluthrin toxicity in honeybee Apis cerana cerana Fabricius by Yunfei Xue, Xueyang Gong, Linfu Yang, Dandan Zhi, Qingxin Meng, Yulong Guo, Kun Dong, Yakai Tian

“…Additionally, nanoPS caused damage to the honeybee gut and hindered the development of the hypopharyngeal glands, whereas cyfluthrin did not produce these pathological changes. Concerning the detoxification-related genes, the two toxins alone and in combination significantly promoted the expression of P450 9E2 and Cyp9Q3 genes, and the upregulation trend was found more significant for the combination. …”
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Extrinsic Factors Influencing Fetal Deformations and Intrauterine Growth Restriction by Wendy Moh, John M. Graham, Isha Wadhawan, Pedro A. Sanchez-Lara

“…While many studies focus on the intrinsic pathological causes, the possible long-term consequences resulting from extrinsic intrauterine physiological constraints merit additional consideration and further investigation. …”
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What Do Gases in the Large Intestine Have to Do with Health? by Klaudia Pawełek, Patrycja Kinga Marta, Filip Maciej Huzarski, Gabriela Monika Ferfecka, Magdalena Rosa-Bończak, Agata Ossolińska, Weronika Kłosowicz, Oliver Carlton, Lucyna Stolarska, Natalia Morawiecka

“…Diagnosis of these conditions relies on breath tests and ruling out other pathologies. Additionally, carbohydrate intolerances, such as fructose or lactose intolerance, result in excessive gas production and malabsorption issues. …”
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Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer by Elena Lastraioli, Jessica Iorio, Francesco Piazza, Chiara Capitani, Michele Santillo, Claudia Duranti, Simonetta Bianchi, Icro Meattini, Scott P. Fraser, Mustafa B. A. Djamgoz, Andrea Becchetti, Annarosa Arcangeli

“…The corresponding proteins were also evaluated by immunohistochemistry and their expression was correlated with clinic-pathological and molecular characteristics and patients’ survival. …”
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Twelve-Month Outcomes and Optical Coherence Tomography (OCT) Biomarkers After Intravitreal Dexamethasone Implantation in Pseudophakic Eyes with Post-Vitrectomy Cystoid Macular Edem... by Francesco Pignatelli, Alfredo Niro, Giuseppe Addabbo, Pasquale Viggiano, Giacomo Boscia, Maria Oliva Grassi, Francesco Boscia, Cristiana Iaculli, Giulia Maria Emilia Clima, Antonio Barone, Ermete Giancipoli

“…<b>Methods</b>: Medical records of consecutive pseudophakic patients, who underwent PPV for different retinal pathologies, were retrospectively evaluated in this single-center, uncontrolled study. …”
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Exploring the Analgesic Effect of Acupuncture on Knee Osteoarthritis Based on MLT/cAMP/PKA/CREB Signaling Pathway by Zhang C, Yu M, Zhang L, Zhou X, Han J, Fu B, Xue H, Zhang C

“…This study aims to explore this mechanism.Methods: In this work, the KOA rabbit model was constructed using the traditional Hulth method, and the therapeutic effect was assessed by the Lequesne MG score and Pain assessment by hot plate test. The pathological alterations of cartilage tissue were observed using hematoxylin and eosin (H&E) staining, Safranin O-fast green and MASSON staining to observe the pathological changes in cartilage tissue, and the efficacy was evaluated according to the principles of Mankin score and Osteoarthritis Research Society International (OARSI) score. …”
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Plasma circulating cell–free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson’s disease and multiple system atrophy: a cross-sectional study by Chao Ying, Chao Han, Yuan Li, Mingkai Zhang, Shuying Xiao, Lifang Zhao, Hui Zhang, Qian Yu, Jing An, Wei Mao, Yanning Cai

“…Both Parkinson’s disease and multiple system atrophy are classified as α-synucleinopathies, characterized by abnormal accumulation of α-synuclein protein, which provides a shared pathological background for their comparative study. …”
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