Conversion of Intermediate Therapies into Intensive Therapies. by Rubén Bembibre Taboada, Carlos Jaime Geroy Gómez, Marcos D. Iraola Ferrer, Julio Cortizo Hernández, Julio Jova Dueñas, Pedro Juan Barrios Fuentes, José Roque Nodal

“…<strong>Results and Conclusions:</strong> Human and material resources were distributed; there were 483 admitted with a standard stay of 2,34 days and a necropsia percentage of 95,15%; a total pathological clinic correlation of 96,66%, and partial of 3,34%. …”
Get full text

Cellular Mechanisms of Multiple Myeloma Bone Disease by Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano

“…MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. …”
Get full text

The Association of High COVID-19 Cases and Mortality with Anomalous High Surface Ozone Concentration in Moscow City in Summer 2021 by E. V. Stepanov, V. V. Andreev, D. V. Chuprov, V. T. Ivashkin

“…The observed noticeable relationship may be due to the combined pathological effect of high concentrations of ozone and the SARS-CoV-2 on the respiratory and circulatory organs, which can lead to both easier transmission of infection and a more severe course of the disease with increased mortality.…”
Get full text

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss by Chengjun Huang, Maoqi Chen, Yingchun Zhang, Sheng Li, Ping Zhou

“…These findings provide valuable insight toward our understanding of the neurophysiological mechanisms underlying experimental observations of muscle strength, force control, and EMG-force relation in both normal and pathological conditions.…”
Get full text

Noradrenergic Modulation of Cognition in Health and Disease by Olga Borodovitsyna, Matthew Flamini, Daniel Chandler

“…We further assess the changes that occur in the noradrenergic system in Alzheimer’s disease, Parkinson’s disease, attention-deficit/hyperactivity disorder, and schizophrenia and how these changes contribute to cognitive decline in these pathologies.…”
Get full text

Defective Laplacians and paradoxical phenomena in crowd motion modeling by Maury, Bertrand

“…In a second part, we describe a pathological situation, in the context of granular crowd motion models. …”
Get full text

State-of-the art of endoscopic semeiology of neuroendocrine tumors of the stomach by I. B. Perfil’yev, V. V Delektorskaya, Yu. P. Kuvshinov, B. K. Poddubny, G. V. Ungiadze, S. S. Pirogov, O. A. Malikhova

“…The complex endoscopic approach in diagnostics NET of the stomach was developed, that included standard examination, narrow-band imaging (NBI) both as independent study and in combination to optical magnification of the image (x115) and subsequent endoscopic ultrasound investigation (EUS) of the pathological focus. This method had been applied in 53 cases with NET of the stomach in N.N.Blokhin Russian Scientific oncological center of the Russian Academy of Medical Science in a period from 2001 to 2010. …”
Get full text

Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse by Qian Wang, Zuoxi He, Lisha Ding, Yuqing Liu, Xiaoli Zhang, Tao Wang, Xiaoyu Niu

“…Pelvic organ prolapse (POP) is a common gynecological disease caused by pathological defects, lesions, or mechanical weakening of the support structures of the pelvic floor. …”
Get full text

Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses by Mariangela Gennaro, Alessandro Mattiello, Tommaso Pizzorusso

“…Translational stroke research requires the use of animal models as they represent a reliable tool to understand the pathogenic mechanisms underlying the generation, progression, and pathological consequences of a stroke. Moreover, in vivo experiments are instrumental to investigate new therapeutic strategies and the best temporal window of intervention. …”
Get full text

Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions by Chary López-Pedrera, Carlos Pérez-Sánchez, Manuel Ramos-Casals, Monica Santos-Gonzalez, Antonio Rodriguez-Ariza, Ma José Cuadrado

“…Traditional risk factors, as well as systemic inflammation mediators, including cytokines, chemokines, proteases, autoantibodies, adhesion receptors, and others, have been implicated in the development of these vascular pathologies. Yet, the characteristics of vasculopathies may significantly differ depending on the underlying disease. …”
Get full text

Injectable hydrogel regulates immune infiltration through physical and chemical synergy in the treatment of steroid-induced osteonecrosis of the femoral head by Zherui Fu, Yiwen Xu, Fangqi Xu, Haoyu Zhou, Na Lin, Ning Zhang, Feng Lin

“…The incidence of steroid-induced osteonecrosis of the femoral head (SONFH) is increasing annually; however, the underlying pathological mechanism remains unclear, which is an obstacle to its effective treatment. …”
Get full text

Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawle... by Retno Murwanti, A. Nurrochmad, Andayana P. Gani, Ediati Sasmito, Angela E. Edwina, Mayang K. Chandra, F. H. Suryawan, A. R. Wardana, null Natalia, Jelita L. S. R. Budiningsih

“…In repeated doses of SKM for 90 days, the administration of 22.5, 45, and 90 mg/kg b.w. per day of the SKM product to female SD rats did not affect clinical signs, body weight, food and water consumption, hematological parameters, clinical chemical parameters, urinalysis, relative organ weights, and gross pathological and histopathological features compared with the control group. …”
Get full text

Accidental intra-arterial injection of enoxaparin sodium leading to abdominal wall expanding subcutaneous hematoma and abdominal wound: case report-vascular by Caroline Howell, Richard Simman, Richard Simman, Richard Simman

“…IntroductionEnoxaparin sodium (Lovenox®) is a commonly used anticoagulant medication that is self-administered via subcutaneous injection to prevent the formation of pathologic blood clots. It is used as a bridge to long-term anticoagulation with warfarin in patients at high risk for thromboembolic events. …”
Get full text

The influence of ambient conditions on a person's socio-political maturation: Example of the blessed Muhammad: A citizen of the world par excellence by Dizdarević Bajram, Efendić Davud

“…Of course, this is an indicator of their concern and not at all a pathological striving for supremacy. Again, since the blessed Muhammad spent the first years of his life in the desert regions, he, in a certain sense, represents the success of both identity cores, which will influence his later clarity of verbal expression, clarity of thought, but also the cultural breadth that is capable of dealing with all human divergence, and to direct it appropriately. …”
Get full text

Oxidative Stress and Cytoskeletal Reorganization in Hypertensive Erythrocytes by Ivette Martínez-Vieyra, Isaac Hernández-Rojo, Víctor Hugo Rosales-García, Aracely Evangelina Chávez-Piña, Doris Cerecedo

“…Oxidative stress is widely recognized as a key mechanism in the development of hypertension. Under pathological conditions, such as in hypertension, oxidative stress leads to irreversible posttranslational modifications of proteins, which result in loss of protein function and cellular damage. …”
Get full text

A Novel Computational Framework for Visual Snow Syndrome by Damiano Perri, Osvaldo Gervasi

“…The questionnaire results show users&#x2019; positive appreciation, as they outline in their comments how important it is for patients to have simulation tools that allow them to better explain their pathologies.…”
Get full text

Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects by Xiao-yan Zhou, Rong Gao, Jian Hu, Da-peng Gao, Yan-ling Liao, Jian-jun Yang

“…Accumulating evidence has demonstrated that immune memory occurs in microglia, which has a significant impact on pathological hallmarks of neurological diseases. However, it remains unclear whether immune memory can cause subsequent alterations in the brain immune response and affect neurobehavioral outcomes in sepsis survivors. …”
Get full text

Zinc in Gut-Brain Interaction in Autism and Neurological Disorders by Guillermo Vela, Peter Stark, Michael Socha, Ann Katrin Sauer, Simone Hagmeyer, Andreas M. Grabrucker

“…Based on these data, we present a novel model outlining how alterations in the maternal zinc status might pathologically impact the offspring leading to impairments in brain functions later in life.…”
Get full text

Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases by Ye. A. Poluektova, Yu. O. Sidorina, S. Yu. Kuchumova, A. V. Korolev, O. S. Shifrin

“…Microbiome changes result in initiation of cascade of pathological immune reactions of the host in related to presence of genetical defects, that, in turn, promotes development of clinical symptoms and morphological changes in intestinal wall. …”
Get full text

Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells by Samanta Melgar-Rodríguez, Emilio A. Cafferata, Nicolás I. Díaz, Miguel A. Peña, Luis González-Osuna, Carolina Rojas, Alfredo Sierra-Cristancho, Angélica M. Cárdenas, Jaime Díaz-Zúñiga, Rolando Vernal

“…Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. …”
Get full text