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  1. 11701
  2. 11702

    Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure by Huan He, Weiwei Huang, Zigang Pan, Lingjun Wang, Zhongqi Yang, Zixin Chen

    Published 2025-01-01
    “…Impaired cardiac energy metabolism plays a critical role in the pathological progression of HF. Various forms of HF exhibit marked differences in energy metabolism, particularly in mitochondrial function and substrate utilization. …”
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    Article
  3. 11703

    Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review by Jong Ryeol Eun

    Published 2025-01-01
    “…Clinically, HCCs exhibit a broad spectrum of pathological and clinical characteristics, ranging from well-differentiated to poorly differentiated forms, and from slow-growing tumors to aggressive ones with significant metastatic potential. …”
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    Article
  4. 11704

    Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test by Chang-soo Chon, Hui-suk Yun, Han Sung Kim, Cheolwoong Ko

    Published 2017-01-01
    “…A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. …”
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    Article
  5. 11705

    Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery by Gianluca Martone, Alessandra Balestrazzi, Giorgio Ciprandi, Angelo Balestrazzi

    Published 2022-01-01
    “…The surgical procedure is associated with damage to the epithelial barrier and interruption of the corneal innervation. In addition, pathological events sustain signs and symptoms that may persist for a long time. …”
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    Article
  6. 11706

    Sempervirine inhibits proliferation, invasion and metastasis of ovarian cancer cells and induces ultrastructural changes in vivo by Danni Chen, Yan Tan, Tingting Chen, Qin Wang, Yan Yan, Xiaoya Zhao, Zhongxiao Zhang, Jin Qiu, Jian Zhang

    Published 2025-01-01
    “…Furthermore, in an orthotopic ovarian cancer mouse model, sempervirine dramatically inhibited tumor growth and induced pathological changes in tumor tissues, including poor development of tumor mucosa, collagen deposition, endoplasmic reticulum damage, mitochondrial swelling and vacuolar degeneration, which were similar to the positive control 5-Fu. …”
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    Article
  7. 11707

    Novel fusion protein REA induces robust prime protection against tuberculosis in mice by Sintayehu Kebede Gurmessa, Han-Gyu Choi, Yong Woo Back, Zongyou Jiang, Thuy An Pham, Seunga Choi, Hwa-Jung Kim

    Published 2025-01-01
    “…Notably, REA-immunized mice suppressed MTB growth to undetectable levels at 16 weeks post-infection, which was supported by gross and pathologic findings and acid-fast staining of the lung tissues, and maintained antigen-specific multifunctional IFN-γ+IL-2+TNF-α CD4+ T and long-lasting T cells producing cytokines in the tissues. …”
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    Article
  8. 11708

    Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections by Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Miguel Marcos, Daniel Salete-Granado, Marirene Chacón-Arnaude, María Á. Pérez-Nieto, Ulrike Kemmerling, Juan Luis Concepción, Paul A. M. Michels, Wilfredo Quiñones

    Published 2025-02-01
    “…In addition, the potential role of these enzymes as targets for drug development and their potential for use as diagnostic and prognostic markers of some pathologies are also discussed.…”
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    Article
  9. 11709

    ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report by Bin Wu, Yinliang Sheng, Zhenyang Geng, Yiming Xu, Xueyuan Fan, Ping Yuan, Feng Li, Yu Qi

    Published 2025-01-01
    “…Abstract Background Carinal resection and reconstruction are complex surgical procedures often necessitated by tumors or other pathologies involving the tracheobronchial junction. …”
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    Article
  10. 11710

    Graph Neural Networks in Brain Connectivity Studies: Methods, Challenges, and Future Directions by Hamed Mohammadi, Waldemar Karwowski

    Published 2024-12-01
    “…Findings reveal that GNNs excel in modeling complex, non-linear connectivity patterns and enable the integration of multiple neuroimaging modalities to provide richer insights into both healthy and pathological brain networks. However, challenges remain, particularly in interpretability, data scarcity, and multimodal integration, limiting the full clinical utility of GNNs. …”
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    Article
  11. 11711

    Collagen fibers quantification for liver fibrosis assessment using linear dichroism photoacoustic microscopy by Yang Qiu, Honghui Li, Kun Yu, Jiali Chen, Li Qi, Yinghua Zhao, Liming Nie

    Published 2025-04-01
    “…Liver fibrosis represents a progressive pathological condition that can culminate in severe hepatic dysfunction, potentially advancing to cirrhosis and liver cancer. …”
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    Article
  12. 11712

    Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4 by Zhe Huang, Ming Wang, Yitian Chen, Hua Tang, Kuo Tang, Mingkuan Zhao, Wei Yang, Zhengjun Zhou, Junjie Tian, Wei Xiang, Shenjie Li, Qinglian Luo, Luotong Liu, Yanru Zhao, Tao Li, Jie Zhou, Ligang Chen

    Published 2025-01-01
    “…We found that expression levels of key migrasome formation factor, tetraspanin 4 (TSPAN4), correlated positively with pathological grade and poor prognosis of GBM based on the databases and clinical samples analysis. …”
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  13. 11713

    Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies by Ilaria Laurenzana, Daniela Lamorte, Stefania Trino, Luciana De Luca, Concetta Ambrosino, Pietro Zoppoli, Vitalba Ruggieri, Luigi Del Vecchio, Pellegrino Musto, Antonella Caivano, Geppino Falco

    Published 2018-01-01
    “…Extracellular vesicles (EVs) are an important cell-to-cell communication type in physiological and pathological conditions. In particular, in HMs, EV secretion participates to unidirectional and bidirectional interactions between neoplastic cells and BM cells. …”
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    Article
  14. 11714
  15. 11715

    The Role of the New Anti-CD20 Monoclonal Antibodies in Active Relapsing – Remitting Multiple Sclerosis Treatment: Efficacy and Safety of ofatumumab by I. Jonušaitė, N. Giedraitienė, G. Kaubrys, R. Kizlaitienė

    Published 2024-03-01
    “…It is important to control neuroinflammation in the central nervous system caused by the pathologic activity of immune cells by considering a high efficacy treatment early in the disease course in order to prevent accumulation of neurological damage and to improve long term outcomes. …”
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    Article
  16. 11716

    Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine by Francesca Veronesi, Melania Maglio, Deyanira Contartese, Lucia Martini, Aurelio Muttini, Milena Fini

    Published 2021-01-01
    “…The use of SVF and AECs could represent a new regenerative treatment in several musculoskeletal pathologies, solving the problem of cell expansion in vitro.…”
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    Article
  17. 11717

    Uncommon Etiology for Seizure: Cerebral Hyperperfusion Syndrome by Mohankumar Kurukumbi, Ahn Truong, Naghemeh Pirsaharkhiz

    Published 2017-01-01
    “…After bilateral CEA, the imaging showed extensive pathologic process involving primarily the subcortical white matter and overlying cortex, more on the right cerebral hemisphere. …”
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  18. 11718

    Impact of Time Delay in Perceptual Decision-Making: Neuronal Population Modeling Approach by Urszula Foryś, Natalia Z. Bielczyk, Katarzyna Piskała, Martyna Płomecka, Jan Poleszczuk

    Published 2017-01-01
    “…Impairments in decision-making are frequently observed in neurodegenerative diseases, but the mechanisms underlying such pathologies remain elusive. In this work, we study, on the basis of novel time-delayed neuronal population model, if the delay in self-inhibition terms can explain those impairments. …”
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  19. 11719

    Tissue Factor, Blood Coagulation, and Beyond: An Overview by Arthur J. Chu

    Published 2011-01-01
    “…Accordingly, TF suppression, anticoagulation, PAR blockade, or general anti-inflammation offers an array of therapeutical benefits for easing diverse pathological conditions.…”
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  20. 11720

    Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

    Published 2025-02-01
    “…An analysis of regenerative variability across pathological states reveals how disease conditions influence these dynamics, guiding the development of novel therapeutic strategies and advanced techniques to enhance liver repair and regeneration. …”
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    Article