Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis by Madonna R. Peter, Mirjana Jerkic, Valentin Sotov, David N. Douda, Daniela S. Ardelean, Niousha Ghamami, Flavia Lakschevitz, Meraj A. Khan, Susan J. Robertson, Michael Glogauer, Dana J. Philpott, Nades Palaniyar, Michelle Letarte

“…We previously demonstrated that Endoglin heterozygous (Eng+/−) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and pathological angiogenesis. We now report that colitic Eng+/− mice have low colonic levels of active TGF-β1, which was associated with reduced expression of thrombospondin-1, an angiostatic factor known to activate TGF-β1. …”
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EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration by Alexandra Collin de l'Hortet, Hélène Gilgenkrantz, Jacques-Emmanuel Guidotti

“…Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.…”
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The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes by Françoise Le Marrec-Croq, Francesco Drago, Jacopo Vizioli, Pierre-Eric Sautière, Christophe Lefebvre

“…Microglia are intrinsic components of the central nervous system (CNS). During pathologies in mammals, inflammatory processes implicate the resident microglia and the infiltration of blood cells including macrophages. …”
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Fundoscopic Changes in Maroteaux-Lamy Syndrome by Augusto Magalhães, Jorge Meira, Ana Maria Cunha, Raul Jorge Moreira, Elisa Leão-Teles, Manuel Falcão, Jorge Breda, Fernando Falcão-Reis

“…Fundoscopic alterations are not usually included in the ocular pathological spectrum of MPS VI. However, with improved control of systemic comorbidities, survival rates of these patients have increased, which in turn has made it possible to observe other changes besides the ones that were classically described. …”
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Case report: Therapeutic use of bortezomib in a patient with Schnitzler syndrome by Hua Bai, Dongming Zhou, Jinwen Liu, Jie He, Zhou Min, Wenyong Fan, Bing Chen, Yong Xu

“…Whole exome sequencing (WES) did not reveal any pathological variants associated with monogenic autoinflammatory diseases or the MYD88 L265P mutation. …”
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Correlation analysis of recurrent factors in borderline ovarian tumors undergoing fertility preservation surgery by Yichi Xie, Dandan Wang, Ningning Zhang, Qing Yang

“…The results of multivariate analysis showed that the pathological features of micro papillary structure, intra operative as cites, bilateral tumors, and the increased ratio of neu tro phil to lymphocyte before surgery are independent risk factors for the recurrence of borderline ovarian tumors.ConclusionThe prognosis of women of childbearing age with borderline ovarian tumors undergoing conservation function surgery is good. …”
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Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets by Soyoung Jeon, Yeram Jeon, Ji-Youn Lim, Yujeong Kim, Boksik Cha, Wantae Kim

“…Disruption of this balance can lead to pathological conditions, including neurodegenerative diseases, cancer, and viral infections. …”
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A myocardial infarction detected in an unusual way by Massimo Barakat, Enrico Bertagnin, Lorenzo Mulazzani, Francesco Galuppi, Sanda Giovanna Nizzardo

“…An abdominal contrast-enhanced computed tomography scan ruled out acute abdominal pathological findings but showed a marked hypoperfusion of the mid-apical anterior wall and the apex of the left ventricle. …”
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Radiographic Findings in Patients with Medication-Related Osteonecrosis of the Jaw by Camila Lopes Cardoso, Carolina Arrabal Barros, Cláudia Curra, Luciana Maria Paes da Silva Ramos Fernandes, Solange de Oliveira Braga Franzolin, Joel Santiago Ferreira Júnior, Carlos César De Antoni, Marcos Martins Curi

“…Panoramic radiography was used for evaluation, by two examiners, the following findings were subject of search: osteolysis (OT), cortical bone erosion (EC), bone sclerosis focal (FS) and diffuse (DS), bone sequestration (BS), thickening of lamina dura (TD), prominence of the inferior alveolar nerve canal (IAN), persisting alveolar sockets (SK), and the presence of a pathological fracture (PF). Medical information and staging were also recorded in order to correlate with radiographic findings. …”
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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? by Veronica Maria Tagi, Veronica Maria Tagi, Martina Tosi, Martina Tosi, Ilenia Pia Greco, Eliana Stucchi, Elvira Verduci, Elvira Verduci, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…Post-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic disorders following beta-hemolytic Streptococcus group A (GAS) infection, hypothesized to be caused by autoimmune mechanisms targeting the basal ganglia. …”
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Closing the gap in dementia research by community-based cohort studies in the Chinese populationResearch in context by Xiaowen Zhou, Zhenxu Xiao, Wanqing Wu, Yuntao Chen, Changzheng Yuan, Yue Leng, Yao Yao, Qianhua Zhao, Albert Hofman, Eric Brunner, Ding Ding

“…We identified critical research gaps and propose future directions, including enhancing sample representativeness, investigating China-specific risk factors, expanding exposure measurements to the whole life-span, collecting objective data, conducting administer-friendly domain-specific cognitive assessments, adopting pathological diagnostic criteria, standardizing biobank construction, verifying multi-modal biomarkers, examining social and genetic-environmental aspects, and monitoring post-COVID cognitive health, to approach high quality of dementia studies that can provide solid evidence to policy making and promote global brain health research.…”
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Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair by Jung-Eun Kim, Woori Ko, Siwoo Jin, Jin-Nyeong Woo, Yuna Jung, Inah Bae, Han-Kyoung Choe, Daeha Seo, Bertil Hille, Byung-Chang Suh

“…TMEM16E- driven macropinocytosis is proposed to restore membrane integrity after perturbation, potentially explaining pathologies in conditions like muscular dystrophies, where TMEM16E functionality is compromised, highlighting its critical role in muscle cell survival.…”
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Neonatal Nonketotic Hyperglycinemia: A Severe Case With Prenatal Indicators and Comprehensive Review of Recognition and Management by Samaneh Parviz, Dariush Hooshyar

“…ABSTRACT Nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy, is a rare inherited neurometabolic disorder caused by a deficiency in the glycine cleavage enzyme system (GCS), leading to the pathological accumulation of glycine in blood and cerebrospinal fluid (CSF). …”
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Targeted correction of megabase-scale CNTN6 duplication in induced pluripotent stem cells and impacts on gene expression by Maria Gridina, Polina Orlova, Oleg Serov

“…However, duplication of the full-length human CNTN6 gene presents with variable penetrance, resulting in phenotypes that range from neurodevelopmental disorders to no visible pathologies, even within the same family. Previously, we obtained a set of induced pluripotent stem cell lines derived from a patient with a CNTN6 gene duplication and from two healthy donors. …”
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Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo by Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…These findings suggest that drugs targeting each fragment may be used to fine-tune the pathological effects of osteopontin in several diseases.…”
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Recurrent Nodular Cystic Goiter. In Regards with a Case by José Alberto Puerto Lorenzo, Lidia Torres Aja, Eslinda Cabanes Rojas

“…A fine needle aspiration biopsy was performed 3 times, with recurrence and a right lobectomy was performed. The anatomic-pathological study reported nodular goiter with cystic degeneration. …”
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Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice by Sisi Chen, Shimin Jia, Keke Suo, Qiaozhen Kang, Limin Hao, Laizheng Lu, Xin Liu, Jinyong Huang, Jike Lu

“…Furthermore, the potential benefits of E-IE on the liver were evaluated by biochemical parameters including the activities of serum transaminase, the levels of antioxidant enzymes, and the pathological changes of liver tissue. The present work put forward a new point that appropriate ethanol stress could enhance the intracellular ADH activity of L. lactis, and its intracellular extracts could continue to enhance alcohol metabolism in mice.…”
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The Vitreomacular Interface in Diabetic Retinopathy by Daniel Agarwal, Rachel Gelman, Claudia Prospero Ponce, William Stevenson, John B. Christoforidis

“…Understanding the cells infiltrating pathologic membranes at the vitreomacular interface has opened up the possibility of new targets for pharmacotherapy. …”
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Gut-Heart Axis: Microbiome Involvement in Restrictive Cardiomyopathies by Samuel Jaimez-Alvarado, Itzel Ivonn López-Tenorio, Javier Barragán-De los Santos, Dannya Coral Bello-Vega, Francisco Javier Roldán Gómez, Amedeo Amedei, Enrique Alexander Berrios-Bárcenas, María Magdalena Aguirre-García

“…The human microbiome, composed of billions of microorganisms, influences various physiological and pathological processes, including cardiovascular health. …”
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Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report by Eya Slama, S. Ben Hamida, S. Zaouga, H. Elloumi, I. Cheikh, A. G. Dahak, M. Missaoui, A. Chelibi, I. Ganzoui

“…An EGD showed a congested infiltrated area in the post-bulbar region, and Pathological exam confirmed the diagnosis of a primary adenocarcinoma of the duodenal bulb. …”
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