Mathematical modelling of cardiac pulse wave reflections due to arterial irregularities by Alexandre Cornet

“…An iterative algorithm is developed and applied to pathological scenarios to predict the pressure waveform of the reflected wave due to the presence of successive arterial irregularities. …”
Get full text

Biofabrication of brain-like living tissue: structure to intelligence by Ling Wang, Sen Wang, Yingjie Liu, Bowen Zhang, Zhaoyu Pan, Luge Bai, Siqi Yao, Chenrui Zhang, Huangfan Xie, Jiankang He, Dichen Li

“…Therefore, constructing brain-like models—both in morphology and function—possesses significant scientific value for advancing brain science and pathological pharmacology research, representing the frontiers in the biomanufacturing field. …”
Get full text

Positive Findings of Blood Cultures in Febrile Children Presenting with Thalassemia Major in a Tertiary Care Hospital by Itrat Fatima, Wafia Affan, Hira Hameed, Wajeeha Amber, Sumbal Saeed, Imran Mahmood Khan

“…Their demographic characteristics and pathological findings were noted in this study. Standardized approach was followed for blood withdrawal and sample collection required for performing blood cultures. …”
Get full text

Role of Apolipoprotein E in Anxiety by Jacob Raber

“…Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. …”
Get full text

Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification by Jantana Keereetaweep, Kent D. Chapman

“…Further, the altered levels of these molecules often reflect pathological conditions associated with tissue damage. …”
Get full text

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation by Agnieszka Loboda, Mateusz Sobczak, Alicja Jozkowicz, Jozef Dulak

“…Recent findings indicate the prominent role of microRNAs, small noncoding RNA molecules that inhibit gene expression through the posttranscriptional repression of their target mRNAs, in different pathologic conditions, including renal pathophysiology. miR-21 was also shown to play a dynamic role in inflammatory responses and in accelerating injury responses to promote organ failure and fibrosis. …”
Get full text

FEATURES OF INFLUENCE OF EMOTIONAL STRESS DURING PREGNANCY ON THE FORMATION OF EATING BEHAVIOR IN THE CHILD by J. R. Gardanova, S. A. Salehov, V. I. Esaulov, D. F. Khritinin, I. I. Abdullin, S. D. Abdyrahmanov, G. A. Galliamova, K. A. Anisimova

“…Anokhin, the endogeneity of the regularities of pathological processes, the pyramid of needs of A. Maslow.Results. …”
Get full text

Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model by Jenny Castro, Guillermo Lopez-Lluch, Juan Carlos Rodríguez, Rocío de la Puerta, Lía Barrios, Rubén Salas, Luis Franco

“…Dietary supplementation with golden berry attenuates the pathological symptoms of colitis. This effect may be associated with the inhibition of neutrophil infiltration and impacts on the production of IL-6, IL-1β, IL-10, TNF-α, and ROS. …”
Get full text

DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer by Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, Abdelaali Balahbib, Abdelhakim Bouyahya, Chrismawan Ardianto, Long Chiau Ming, Hooi Leng Ser

“…DNMTs play a central role in the epigenetic regulation of the human genome, both in normal and pathological processes. Recent discoveries on the differentiated roles of DNMTs in DNA methylation, and their implication in various cancers, open the way to new therapeutic approaches targeting these enzymes to treat epigenetic diseases. …”
Get full text

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to expand therapeutic options for central nervous system pathologies. While previous strategies have focused on small molecules that modulate blood-brain barrier permeability or penetrate the barrier, there is an increased focus on biomedical devices—external or implanted—for improving drug delivery. …”
Get full text

Down-Turner Syndrome: A Case with Double Monoclonal Chromosomal Abnormality by Gioconda Manassero-Morales, Denisse Alvarez-Manassero, Alfredo Merino-Luna

“…Female, 28 months old, with pathological short stature from birth, with the following dysmorphic features: tilted upward palpebral fissures, short neck, brachycephaly, and low-set ears. …”
Get full text

Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

“…Over the years, significant advances have been made in understanding their potential physiological and pathological functions. Depending on their calcium requirement for activation, PLA2s are classified into calcium dependent and independent. …”
Get full text

Complex Brain Network Analysis and Its Applications to Brain Disorders: A Survey by Jin Liu, Min Li, Yi Pan, Wei Lan, Ruiqing Zheng, Fang-Xiang Wu, Jianxin Wang

“…These findings provide not only a new perspective to explore the pathological mechanisms of brain disorders, but also guidance for early diagnosis and treatment of brain disorders. …”
Get full text

The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…In this review, we elaborate on the key pathological mechanisms that unfold following ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, and present evidence demonstrating that 12/15-LOX inhibition could be used to treat ischemic stroke through various avenues. …”
Get full text

Blockchain-enabled digital twin system for brain stroke prediction by Venkatesh Upadrista, Sajid Nazir, Huaglory Tianfield

“…The application can be extended to monitor other pathologies such as heart attacks, cancers, osteoporosis, and epilepsy with minimal configuration changes.…”
Get full text

Enuresis, a problem to be faced in Primary Health Care due to its educational component by Mislandy Caridad González Guevara, Helena Fernández Esperanza, Marta Amelia Hernández Martínez, Owen Daniel González Cruz

“…Results: the male sex prevailed (71.4%) and 64.3% were grouped between the ages of seven and nine, nine had a family pathological history and 64.3% were affected by parental divorce; They reported poor concentration and interaction in the group, average or poor school performance, and sadness. …”
Get full text

Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration by Cassiano Felippe Gonçalves de Albuquerque, Patrícia Burth, Mauricio Younes Ibrahim, Diogo Gomes Garcia, Patrícia Torres Bozza, Hugo Caire Castro Faria Neto, Mauro Velho Castro Faria

“…Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albumin concentrations are correlated to the disease severity. …”
Get full text

Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence by Masato Yasui, Ryosuke Jikuya, Tomoyuki Tatenuma, Kentaro Muraoka, Susumu Umemoto, Masaki Kawai, Tsutomu Kouno, Takeshi Kishida

“…The tumor was removed, along with adhering surrounding organs, including the omentum, peritoneum, abdominal rectus muscle, and vermiform appendix. Although pathological examination confirmed peritoneal dissemination, his tumor markers normalized soon after surgery. …”
Get full text

Gynecological endoscopic surgery in Cienfuegos. by Alberto Jorge Fernández, Alexis Díaz Brito, Israel Sotolongo Castro, Gabriel Jiménez González, Rafael Alejandro Gómez Baute

“…<strong><br />Results: </strong>The most recent gynaecological pathologies were: Pelvic Inflammatory Disease, infertility and ovarian cyst. …”
Get full text

Spontaneous Intraperitoneal Rupture of Bladder Diverticulum: A Rare Cause of Peritonitis by Ahmed Ibrahimi, Adil Kallat, Idriss Ziani, Hachem El Sayegh, Lounis Benslimane, Yassine Nouini

“…Spontaneous rupture of acquired bladder diverticulum in an adult patient is an extremely rare pathological entity with only 15 cases reported in the available literature. …”
Get full text