Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot by Pablo Méndez, Alberto Bacci

“…Here, some aspects related to plasticity and modulation of adult cortical and hippocampal GABAergic synaptic transmission will be reviewed, aiming at providing a fresh perspective towards the elucidation of the role played by specific cellular elements of cortical microcircuits during both physiological and pathological operations.…”
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Mowat-Wilson Syndrome: The First Clinical and Molecular Report of an Indonesian Patient by Farmaditya E. P. Mundhofir, Helger G. Yntema, Ineke van der Burgt, Ben C. J. Hamel, Sultana M. H. Faradz, Bregje W. M. van Bon

“…All molecularly confirmed cases with typical MWS have a heterozygous loss-of-function mutation in the zinc finger E-box protein 2 (ZEB2) gene, also called SIP1 (Smad-interacting protein 1) and ZFHX1B, suggesting that haploinsufficiency is the main pathological mechanism. Approximately 80% of mutations are nonsense and frameshift mutations (small insertions or deletions). …”
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Cellular rejuvenation protects neurons from inflammation-mediated cell death by Sienna S. Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Matthew A. Hintermayer, Yuancheng Ryan Lu, David Gosselin, Stephanie Zandee, Alexandre Prat, Jo Anne Stratton, David A. Sinclair, Alyson E. Fournier

“…Collectively, these data reveal an aging-like phenotype in neurons under pathological neuroinflammation and support the possibility that rejuvenation therapies or senotherapeutic agents could offer a direct avenue for neuroprotection in neuroimmune disorders.…”
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PRIMARY MANAGEMENT EVALUATION OF SPINAL CASES BY PHYSICIANS IN SãO PAULO HEALTH NETWORKS by GABRIELA NEVES VAZ, FÁBIO ANTÔNIO VIEIRA, RENATO HIROSHI SALVIONI UETA, EDUARDO BARROS PUERTAS

“…ABSTRACT Objectives: To evaluate the clinical management of spinal pathologies by non-specialist medical professionals in the healthcare networks of the state of São Paulo. …”
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Review of the Predictive Value of Biomarkers in Sepsis Mortality by Nai Zhang, Yujuan Liu, Chuang Yang, Xinai Li

“…This research concentrates on the significance of CAR in the pathological process of sepsis, its association with prognosis, and the latest developments in employing procalcitonin, lactic acid, CRP, and other potential biomarkers. …”
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Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1 by Fan Zhang, Shaobai Li, Hao Wu, Shanshuang Chen

“…Mapping of human disease-associated point mutations suggests potential pathological mechanisms and paves the way for future studies on the importance of lipid binding, central vestibule and oligomerization of Vangl, thereby providing insights into the molecular mechanisms of the PCP signaling pathway.…”
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Saving a Child’s Elbow Joint: A Novel Reconstruction for a Tumour of the Distal Humerus by Calogero Graci, Czar Louie Gaston, Robert Grimer, Lee Jeys, Korhan Ozkan

“…We have not recorded any complication associated with this technique such as nonunion, pathological fracture, infection, and bone necrosis and we obtained an excellent functional result. 10 years after surgery, the patient had no recurrence. …”
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A Ruptured Digital Epidermal Inclusion Cyst: A Sinister Presentation by Iain Bohler, Phillip Fletcher, Amanda Ragg, Andrew Vane

“…Lesions are asymptomatic unless complicated by rupture, malignant transformation to squamous cell carcinoma, or infection at which point they can clinically appear as more sinister pathologies. We present the case of a 45-year-old laborer with a ruptured epidermal inclusion cyst, manifesting clinically and radiographically as a malignancy. …”
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Biomechanical Simulation of Peyronie’s Disease by Pavel Drlík, Vladimír Červenka, Jan Červenka

“…A pathological disorder of human penile function, known as Peyronie’s disease, is characterized by the formation of plaque particles within the tunica albuginea. …”
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Completion Phenomenon in Transcortical Sensory Aphasia by Y. Nakagawa, H. Tanabe, M. Ikeda, H. Kazui, K. Ito, N. Inoue, Y. Hatakenaka, T. Sawada, H. Ikeda, J. Shiraishi

“…Together with the present findings, these results suggest that lack of proverb completion may be attributed to a selective, systematic and complete loss of the meaning representations for language units such as words and proverbs. In addition, pathological processes of focal atrophy with temporal predominance might selectively affect the semantic memory for language as a unit.…”
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Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines by Chi-Won Choi, Edmond Changkyun Park, Sung Ho Yun, Sang-Yeop Lee, Seung Il Kim, Gun-Hwa Kim

“…Although the S. pneumoniae bacteria were highly pathogenic in a mouse model, the EMVs purified from these bacteria showed low pathological activity both in cell culture and in mice. …”
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A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review by Agata Sebastian, Joanna Kosałka-Węgiel

“…Furthermore, EGPA often occurs in phases, with clinical manifestations and pathological findings varying depending on the affected anatomic site and stage of disease. …”
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Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke by He-Yan Tian, Yun-Xing Lei, Jing-Tao Zhou, Long-Jun Liu, Tong Yang, Yue Zhou, Jin-Wen Ge, Jin-Wen Ge, Chen Xu, Zhi-Gang Mei

“…PANoptosis and autophagy, both vital players in the intricate pathological progression of ischemic stroke (IS), a brain ailment governed by intricate cell death cascades, have garnered attention in recent years for their potential interplay. …”
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Skeletal Muscle Lymphoma Presenting with Chronic Compartment Syndrome of Leg after Trauma by Jhong-You Li, Chung-Liang Li, Chun-Kuan Lu

“…Preoperative laboratory tests were within normal limits. Postoperative pathologic examination and bone marrow aspiration revealed B-cell lymphoma with bone marrow involvement postoperatively. …”
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Primary Nasal Tuberculosis by Varun Jerath, Bipin Kishore Prasad, Yamuna Ranganathan, Sunil Goyal

“…Tuberculosis primarily occurring in the nose, poses a diagnostic challenge, as the clinical presentations of other important pathologies such as infective and inflammatory diseases, granulomatous disorders and neoplastic conditions are similar, have an indolent course and are non-specific. …”
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𝛽-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload by Luca Melchiori, Sara Gardenghi, Stefano Rivella

“…The sequelae of IE lead to extramedullary hematopoiesis (EMH) with massive splenomegaly and dramatic iron overload, which in turn is responsible for many of the secondary pathologies observed in thalassemic patients. The processes are intimately linked such that an ideal therapeutic approach should address all of the complications. …”
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The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? by Marco Paolo Donadini, Francesca Calcaterra, Erica Romualdi, Roberta Ciceri, Assunta Cancellara, Corrado Lodigiani, Monica Bacci, Silvia Della Bella, Walter Ageno, Domenico Mavilio

“…Venous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). …”
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PREVALENCE OF RAMADAN AND FASTING RELATED DIABETICCOMPLICATIONS AMONG DIABETIC PATIENTS by Aisha Noreen et al

“…Various researches have been conducted upon physiological changes in a diabetic patient during the period of Islamic fasting, but still there is no variation perceived pathologically influencing the body weight, blood glucose, HbA1c, insulin, fructose amine, Cpeptide, cholesterol or triglycerides ranges. …”
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Gallbladder adenomyomatosis in an older adult: clinical and histopathological presentation by Alberto Aristides Artiles Garcia, Felipe Jorge Aragón Palmero, Belkis Sonia Cañizares García, Emma Midiannys Griñan Fonte

“…A laparoscopic cholecystectomy was performed with a pathological diagnosis of gallbladder adenomyomatosis. …”
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The Cytoreductive Effect of Radiotherapy for Small Cell Ovarian Carcinoma of the Pulmonary Type: A Case Report and Review of the Literature by Shuhei Terada, Takashi Suzuki, Akihiro Hasegawa, Satoru Nakayama, Hiroshi Adachi

“…The postoperative pathological diagnosis was small cell ovarian carcinoma of the pulmonary type. …”
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