Menopause mysteries: the exosome-inflammation connection by Aarushi Sultania, Subhashini Brahadeeswaran, Aparna Eledath Kolasseri, Sivaraman Jayanthi, Ramasamy Tamizhselvi

“…It also explores the complex functions of FF exosomal proteins in the pathologies associated with menopause. Graphical Abstract…”
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Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…Primary brain injury is an immediate and, therefore, rather irreversible effect of trauma, while secondary brain injury results from a complex cascade of pathological processes, among which oxidative stress and neuroinflammation are the most prominent. …”
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Observations on trials of potoclean<sup>®</sup> as a teat-dipping disinfectant by Ahmet Semacan, Uçkun Sait Uçan, S. Merve Temimhan, Ülküm Çizmeci

“…Skins of the quarters to which test disinfectant has been applied did not showed any alterations as evidenced clinically by during the trial, although it was not analyzed histo-pathologically. The test disinfectant by comparison with the control showed that it may have a potential to prevent mastitis as evidenced by this preliminary observation.…”
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Сhronic relapsing inflammatory optic neuropathy: diagnostic strategies and treatment (literature review) by T.I. Nehrych, M.B. Kopchak, S.Ya. Kyryliuk

“…An analysis of foreign works published in the E-Library, CrossRef, PubMed, Web of Science, Scopus databases was carried out in order to systematize data on the etiology, pathogenesis, clinical manifestations, diagnostic criteria, differential diagnosis and treatment of this pathological condition. It has been established that chronic recurrent inflammatory optic neuropathy is a rare, recurrent, corticosteroid-dependent optic neuropathy in which there is no other neurological deficit, no etiological factor is identified and it is a diagnosis of exclusion. …”
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The Role of PPAR Gamma in Systemic Sclerosis by Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta

“…Aberrant PPARγ function seems to be implicated in pathological fibrosis in the skin and lungs. This antifibrotic effect is mainly related to the inhibition of TGF-β/Smad signal transduction but other pathways can be involved. …”
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Risk Factors Predicting Recurrent Small Intestinal Resection for Crohn’s Disease of the Terminal Ileum by Hanna Binder, Hugh J Freeman

“…Univariate and multivariate analyses of multiple demographic, clinical, laboratory and pathological variables revealed two apparent statistically significant independent risk factors for a second intestinal resection: steroid treatment, likely an indirect indication of more severe disease activity; and the presence of an internal fistula, consistent with the emerging concept of a relatively more aggressive clinical form of Crohn’s disease.…”
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The investigation of vestibulary system in patients with thyroid dysfunctions by Ci̇gdem Firat Koca, Lezan Keski̇n, Mehmet Kelles, Turgut Celi̇k, Sukru Aydin, Seyma Yasar

“…A relationship has been detected among thyroid dysfunctions and vestibular pathologies. Our aim was to evaluate the vestibular system in cases with thyroid dysfunctions. …”
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Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia by Halina Baran, Marcelin Jan Pietryja, Berthold Kepplinger

“…Dietary supplementation with natural molecular/herbal extracts, exercise, and physical activity have significant impacts on endogenous pharmacology by reducing kynurenic acid synthesis, and these factors are likely to significantly modulate steady-state biological conditions and delay the negative consequences of aging, including the onset of pathological processes.…”
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Müllerianosis of the urinary bladder in pre- and postmenopausal women: a literature review by Dimitrios Diamantidis, Georgios Tsakaldimis, Stavros Lailisidis, Evangelia Deligeorgiou, Nikolaos Panagiotopoulos, Nektraria Kritsotaki, Charalampos Kafalis, Chousein Chousein, Stilianos Giannakopoulos, Christos Kalaitzis

“…Müllerianosis of the urinary bladder is a rare pathological condition involving ectopic Müllerian-derived tissues within the bladder. …”
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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung by William J. Mach, Amanda R. Thimmesch, J. Thomas Pierce, Janet D. Pierce

“…Oxygen is therapeutic for treatment of hypoxemia and hypoxia associated with many pathological processes. Pathophysiological processes are associated with increased levels of hyperoxia-induced reactive O2 species (ROS) which may readily react with surrounding biological tissues, damaging lipids, proteins, and nucleic acids. …”
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DETECTION OF LUMPY SKIN DISEASE VIRUS GENOME IN FIELD SAMPLES COLLECTED FROM CATTLE IN THE RUSSIAN FEDERATION by A. V. Kononov, A. V. Sprygin, S. V.  Kononova, A. A.  Nesterov, P. V.  Prutnikov, Ye. Ye. Artyukhova, Ye. S.  Kostrova, I. N. Shumilova

“…Results of laboratory tests of pathological and biological material samples for lumpy skin disease virus genome with the FGBI “ARRIAH” lumpy skin disease real-time PCR test system are presented. …”
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Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine sett... by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

“…Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated disorders, including cerebral ischemia, to mitigate hypoxia- and reoxygenation-induced neuronal damage. …”
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Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice by Aimei Liaoa, Xing Lyu, Jiarui Ma, Yinchen Hou, Ming Hui, Na Liu, Yi Zhao, Yixiang Cui, Jihong Huang

“…WEG also increased total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in the liver and brains of aging mice, and reduced malondialdehyde (MDA) content. Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice. …”
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Wet pulverization combined with temperature cycling strategy for extraction of Stropharia rugosoannulata protein with attenuating hepatic steatosis on obese mice by Peng Liu, Chen Gao, Wen Li, Wanchao Chen, Zhong Zhang, Di Wu, Tingzhao Li, Shuai Sun, Yan Yang

“…SRA alleviated the pathological progression in obese mice induced by high-fat diet via regulating lipid metabolism in liver and adipose tissues. …”
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Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy by Svetlana F. Khaiboullina, Ekaterina V. Martynova, Sergey N. Bardakov, Mikhail O. Mavlikeev, Ivan A. Yakovlev, Arthur A. Isaev, Roman V. Deev, Albert A. Rizvanov

“…Lack of functional dysferlin inhibits muscle fiber regeneration in voluntary muscles, the main pathological finding in LGMD2B patients. However, the immune system has been suggested to contribute to muscle cell death and tissue regeneration. …”
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Iron Loading and Overloading due to Ineffective Erythropoiesis by Toshihiko Tanno, Jeffery L. Miller

“…The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis.…”
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Deconjugation of Bile Acids with Immobilized Genetically Engineered Lactobacillus plantarum 80(pCBH1) by M. L. Jones, C. Martoni, H. Chen, W. Ouyang, T. Metz, S. Prakash

“…However, bile acids can be toxic when produced in pathologically high concentrations in hepatobileary and other diseases. …”
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Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma: A Single-Center Retrospective Study by Feng Cheng, Yanyan Chen, Lei Zhu, Bin Zhou, Yonghong Xu, Yiran Chen, Liping Wen, Shuzheng Chen

“…Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retrospectively analyzed. Clinical and pathological risk factors for lymph node metastasis (LNM), central lymph node metastasis (CLNM), and lateral lymph node metastasis (LLNM) were analyzed. …”
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Elusive modes of Foxp3 activity in versatile regulatory T cells by Minghong He, Yongqiang Feng

“…However, this model has not been rigorously tested in physiological and pathological conditions where Treg cells adapt their function in response to environmental cues, raising questions about the contribution of Foxp3-dependent gene regulation to their versatility. …”
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Fetal intracranial hemorrhage in second trimester: An ominous finding even after a normal array by Yu-Hong Long, Si-Qi Wu, Xin Wang, Li-Ping Wu, Yi-Min Xiong, Xin Yang, Feng-Xiang Wei

“…Consequently, the couple chose to terminate the pregnancy and refused the pathological examination of the fetus. Conclusion: This case underscores the importance of image-assisted examinations such as prenatal ultrasound and MRI, and that WES is a critical tool to establish the genetic etiology.…”
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