Bronchoscopic‐Guided Selective Endobronchial Injection of Methylene Blue Solution for Localising Peripheral Bronchopleural Fistulas During Pleural Debridement in a Post‐Lobectomy P... by Yi Wei, Ke Wang, Honglei Tao, Zhongliang He, Weihua Xu

“…ABSTRACT The bronchopleural fistula (BPF) is a pathological passageway between the bronchus and the pleural cavity. …”
Get full text

Helicobacter pylori: pathogenesis by P. Sabanas, L. Jonaitis

“…The latest mechanisms of how H. pylori interact with host tissue and microbiome, induces and modulates its pathogenicity, and influences the development of malignant disease as well as extragastric pathologies are represented in our review article. Treatment success rates by the current guidelines-based regimens remain suboptimal due to the increasing antimicrobial resistance of H. pylori. …”
Get full text

Neural Plasticity in Common Forms of Chronic Headaches by Tzu-Hsien Lai, Ekaterina Protsenko, Yu-Chen Cheng, Marco L. Loggia, Gianluca Coppola, Wei-Ta Chen

“…While headache may be physiological in the acute setting, it can become a pathological and persistent condition. The mechanisms underlying the transition from episodic to chronic pain have been the subject of intense study. …”
Get full text

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…To date, antisense oligonucleotide (ASO) drugs targeting the pathological genes associated with ALS and HD have shown promising results in numerous animal studies and several clinical trials. …”
Get full text

Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration by Giuseppina Di Giacomo, Salvatore Rizza, Costanza Montagna, Giuseppe Filomeni

“…In the last years, increased levels of S-nitrosothiols (SNOs) have been tightly associated with the onset of nitroxidative stress-based pathologies (e.g., cancer and neurodegeneration), conditions in which alterations of mitochondrial homeostasis and activation of cellular processes dependent on it have been reported as well. …”
Get full text

Local Regeneration of Dentin-Pulp Complex Using Controlled Release of FGF-2 and Naturally Derived Sponge-Like Scaffolds by Chiaki Kitamura, Tatsuji Nishihara, Masamichi Terashita, Yasuhiko Tabata, Ayako Washio

“…When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. …”
Get full text

Lipoma Arborescens of the Knee: Report of Three Cases and Review of the Literature by Ioannis Tsifountoudis, Dimitrios Kapoutsis, Anastasios-Nektarios Tzavellas, Ioannis Kalaitzoglou, Apostolos Tsikes, George Gkouvas

“…We report three cases of lipoma arborescens affecting the knee, the first in a young male without previous history of arthritis or trauma, the second in a 58-year-old male associated with osteoarthritis, and the final in a 44-year-old male diagnosed with psoriatic arthritis, which cover the entire pathologic spectrum of this unusual entity. We highlight the clinical findings and imaging features, by emphasizing especially the role of MRI, in the differential diagnosis of other, more complex intra-articular masses.…”
Get full text

Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives by Anna Chiara Piscaglia, Mariachiara Campanale, Antonio Gasbarrini, Giovanni Gasbarrini

“…Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). …”
Get full text

A Complex Facial Trauma Case with Multiple Mandibular Fractures and Dentoalveolar Injuries by Yeliz Guven, Sevgi Zorlu, Abdulkadir Burak Cankaya, Oya Aktoren, Koray Gencay

“…This case report is important since it presents a variety of pathological sequelae to trauma within one case.…”
Get full text

TREM1—Microglia crosstalk: Neurocognitive disorders by Huashan Li, Wanqiu Yu, Xue Zheng, Zhaoqiong Zhu

“…They predominantly arise as pathological sequelae of central nervous system (CNS) disorders. …”
Get full text

Management of Neonatal Diabetes due to a KCNJ11 Mutation with Automated Insulin Delivery System and Remote Patient Monitoring by Ming Yeh Lee, Anna L. Gloyn, David M. Maahs, Priya Prahalad

“…We present a case of NDM in a proband initially presenting with focal seizures and diabetic ketoacidosis due to a pathologic mutation in the beta cell potassium ATP channel gene KCNJ11 c.679G > A (p.E227K). …”
Get full text

Delayed Diagnosis of McCune–Albright Syndrome by Bereket Fantahun, Seblewongel Desta

“…She was diagnosed with MAS at the age of five years. She had pathological fractures at multiple sites and had raised thyroid hormones since the age of 3½ years. …”
Get full text

The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury by Antonietta Rossi, Carlo Pergola, Salvatore Cuzzocrea, Lidia Sautebin

“…This concept may provide new insights into the interpretation of the protective effect of 5-LO inhibition, which may be useful in the therapy of pathological conditions associated with septic and nonseptic shock and ischemia-reperfusion injury.…”
Get full text

Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury by Lili Quan, Akiko Uyeda, Ichiro Manabe, Rieko Muramatsu

“…In this study, by functionally screening the highly expressed genes in the pathological state of spinal astrocytes, heterogeneous nuclear ribonucleoprotein U (Hnrnpu) is identified as a potential endogenous molecule that regulates astrocyte proliferation and the following scar formation. …”
Get full text

Schizophrenia and Hyperostosis Frontalis Interna with History of Head Injury by Fatima Elghazouani

“…We surmise that the long-term pathological effects of traumatic brain injury, including hyperostosis frontalis interna, are likely to interact with genetic vulnerability and may lead to schizophrenic disorder.…”
Get full text

Sarcomas not rhabdomyomata of soft parts. Presentation of a case. by Julio Sarmiento Sánchez, Dorys González Díaz, Lidia Torres Aja

“…When carrying out the surgical intervention, the anato- pathological report informed that it was a sarcoma not rhabdomyomata of soft parts.…”
Get full text

Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature by Hussein Algahtani, Ahmad Subahi, Bader Shirah

“…Autopsy studies are needed to further understand the pathological mechanism.…”
Get full text

Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva by Qiwen Li, Quan Yuan

“…Therefore, studying the pathological mechanism and developing efficient drugs for FOP are highly demanding. …”
Get full text

Thesis-Building: Architecture, Alchemy and the Constructive Moment(s) of a Doctoral Dissertation by Willem de Bruijn

“…This paper, then, can be read as no more, or less, than a pathological guide to the PhD, where architecture and alchemy come into play as polar opposites in the process of construction and change that thesis-building is.…”
Get full text

The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis by Zixia Huang, Mingyue Wu, Lijin Zeng, Deming Wang

“…Atherosclerosis is the pathological basis for much CVD, including coronary heart disease, acute myocardial infarction, and stroke. …”
Get full text