Neuro-inflammation, depression and fatigue in ESRD: Emerging role of microglia and acupuncture as a new treatment addressing neuro-inflammation in ESRD by Suandika Made, Handayani Rahmaya Nova, Muti Refa Teja

“…Chronic inflammation and other pathological factors contribute to the occurrence of both of the aforementioned consequences. …”
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The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP by Mimi Gao, Roland Winter

“…Its development is hallmarked, among others, by the dysfunction and degeneration of β-cells of the pancreatic islets of Langerhans. The major pathological characteristic thereby is the formation of extracellular amyloid deposits consisting of the islet amyloid polypeptide (IAPP). …”
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Complement Inhibition as a Proposed Neuroprotective Strategy following Cardiac Arrest by Brad E. Zacharia, Zachary L. Hickman, Bartosz T. Grobelny, Peter A. DeRosa, Andrew F. Ducruet, E. Sander Connolly

“…Due to the profound impact of GCI/R injury following OHCA, and the relative lack of effective neuroprotective strategies for this pathologic process, complement inhibition provides an exciting opportunity to augment existing treatments to improve patient outcomes. …”
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Splenic Involvement in Hereditary Hemorrhagic Telangiectasia by Susumu Takamatsu, Kota Sato, Shunsuke Kato, Hiroto Nagano, Shunro Ohtsukasa, Yasuyuki Kawachi

“…He underwent splenectomy, and his symptoms disappeared after surgery. Pathological examination of the resected specimen revealed that the hypervascular lesion of the spleen was not a tumor but was composed of abnormal vessels associated with hereditary hemorrhagic telangiectasia. …”
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Breastfeeding impact on kidney health : updated evidence by Hakim RAHMOUNE, Nada BOUTRID, Hala BOUTRID

“…The findings consistently demonstrate that breastfeeding is associated with enhanced renal growth, improved kidney function, and a diminished risk of various renal pathologies. Specifically, breastfed infants exhibit significantly larger renal volumes and elevated glomerular filtration rates, compared to their formula-fed counterparts. …”
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Single Photon Emission Tomography Imaging in Parkinsonian Disorders: A Review by Paul D. Acton, P. David Mozley

“…Parkinsonian symptoms are associated with a number of neurodegenerative disorders, such as Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy. Pathological evidence has shown clearly that these disorders are associated with a loss of neurons, particularly in the nigrostriatal dopaminergic pathway. …”
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Decoding mitochondrial DNA damage and repair associated with H. pylori infection by Aashirwad Shahi, Dawit Kidane

“…Overall, the review summarizes evidence to understand the dynamics of mitochondria genome and the impact of mtBER in innate immune response during H. pylori-associated pathological outcomes.…”
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The unexpected role of the STING protein in lipid metabolism by Vila, Isabelle K., Laguette, Nadine

“…Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. …”
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Biomaterial-based regenerative therapeutic strategies for spinal cord injury by Keyi Chen, Wei Yu, Genjiang Zheng, Zeng Xu, Chen Yang, Yunhao Wang, Zhihao Yue, Weien Yuan, Bo Hu, Huajiang Chen

“…Unfortunately, due to the complex pathological mechanisms and unique postinjury microenvironment, there is currently no way to completely repair the injured spinal cord. …”
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Palmitoylation as a Functional Regulator of Neurotransmitter Receptors by Vladimir S. Naumenko, Evgeni Ponimaskin

“…This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.…”
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Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…RING-type E3 ubiquitin ligases catalyse the posttranslational proteolytic and nonproteolytic functions in various physiological and pathological processes, such as inflammation-associated signal transduction. …”
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A Technical Nuance to Avoid Lumbar Five Radiculopathy with Anterior Lumbar Fusion and Posterior Instrumentation by Matthew T. Neal, Maziyar A. Kalani, Mark K. Lyons

“…The anterior lumbar interbody fusion (ALIF) is a well-established procedure used to treat a multitude of spinal pathologies. When performed at the L5-S1 level, the ALIF is often supplemented with posterior pedicle screw and rod fixation. …”
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Therapeutic Application of rTMS in Atypical Parkinsonian Disorders by Chrysi Petsani, Athina-Maria Aloizou, Vasileios Siokas, Lambros Messinis, Eleni Peristeri, Christos Bakirtzis, Grigorios Nasios, Efthimios Dardiotis

“…Brain stimulation via repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive intervention using a magnetic coil, and it is considered an alternative therapy in various neuropsychiatric pathologies. In this paper, we review the available studies that investigate the efficacy of rTMS in the treatment of these APDs and Parkinson plus syndromes. …”
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Restenosis and Therapy by Laszlo Denes, Laszlo Entz, Veronika Jancsik

“…Various insults are shown to initiate the phenotype switch of VSMCs. The pathological process, leading to activated inflammatory process, complement activation, and release of growth factors, initiate the proliferation of VSMCs in the media and cause luminal narrowing and impaired vascular function. …”
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The Importance of Lung Innate Immunity During Health and Disease by Gusty Rizky Teguh Ryanto, Ratoe Suraya, Tatsuya Nagano

“…Disturbances in lung innate immunity properties and processes, whether over-responsiveness of the process triggered by innate immunity or lack of responses due to dysfunctions in the immune cells that make up the innate immunity system of the lung, could be correlated to various pathological conditions. In this review, we discuss globally how the components of lung innate immunity are important not only for maintaining lung homeostasis but also during the pathophysiology of notable lung diseases beyond acute pulmonary infections, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis.…”
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Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases by Wuhao Li, Peiyang Cai, Ye Xu, Weihong Tian, Licong Jing, Qiaoyi Lv, Yangjing Zhao, Hui Wang, Qixiang Shao

“…In addition, we will discuss the physiological and pathological implications of MQC in B cells, providing new insights into potential therapeutic targets for diseases associated with B cell abnormalities.…”
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A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma by J. K. Ma, J. Barr, S. Vijayakumar

“…The authors present a case of a 50-year-old woman diagnosed with EH of the iliac bone and acetabulum, who experienced pathological fracture at presentation. This report describes a multidisciplinary approach to the management that includes initial incisional biopsy, curettage, and bone grafting, followed by Intensity Modulated Radiation Therapy. …”
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Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications by Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani, Francesco Parmeggiani

“…Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. …”
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Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice by Qianqian Zhang, Xiaofeng Yu, Linghan Tian, Yanjun Cong, Linfeng Li

“…The main evaluation indexes used were levels of mast cell proteases, histamine, and specific antibody immunoglobulin E (IgE), as well as cytokine secretion and pathological observation. The results showed that both EGC and EGCG significantly reduced levels of mast cell protease, histamine, specific IgE antibodies, and Th2 cytokines in allergic mice. …”
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Advanced Role of Neutrophils in Common Respiratory Diseases by Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, Fang Wang

“…They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respiratory diseases. However, the pathological mechanism of neutrophils remains complex and obscure. …”
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